Organisms-on-Chips
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E:Engineering and Technology".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 13718
Special Issue Editors
Interests: microfluidics; multiphase flow; organism-on-a-chip; biosensor; point-of-care diagnostics; point-of-need detection; cell and particle separation; sample preparation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Small organisms such as Caenorhabditis elegans (worm), Drosophila melanogaster (fruit fly), and Danio rerio (zebrafish) are excellent models for disease investigation and drug discovery. They offer many advantages including genetic homology to humans, biological simplicity, transparency, and amenability to genetic manipulation which are important assets for neurobehavioral studies in a whole biological system. Conventional manual or equipment-intensive methods for organism assays are slow and mostly qualitative. In the past two decades, many microsystems have been developed for worm, fruit fly and zebrafish studies and facilitated automation, control and high-throughput quantitative analysis on these models. Many microfluidic devices have been developed for studying the organisms’ neuronal and behavioral responses to various environmental cues such as chemicals, electrical signals, mechanical forces and light, to name a few. It is anticipated that these microfluidic devices will play a major role in facilitating fundamental disease investigations and high throughput drug discovery assays involving small-scale model organisms. Accordingly, this special issue seeks to provide the most recent advances made by the lead researchers in the area of Organism-on-a-Chip, via publication of original research papers, communications and review articles that focus on novel and recent microfluidic and miniaturized devices for the above organisms and other small models.
Prof. Dr. Pouya Rezai
Prof. Dr. Wenhui Wang
Guest Editors
Manuscript Submission Information
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Keywords
- Microfluidic
- Lab on a Chip
- Organism on a chip
- C. elegans, D. melanogaster, D. rerio
- Worm, Fly, Zebrafish
- Disease
- Toxicology
- In-vivo screening
- Drug discovery
- Chemical screening
- Behavioural screening
- Neuronal screening
- Cellular and subcellular screening
- Phenotypic screening
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Related Special Issue
- Microfluidics for Cells and Other Organisms in Micromachines (14 articles)