Special Issue "Titanium and Its Alloys for Biomedical Applications"
Deadline for manuscript submissions: 1 November 2021.
Metallic biomaterials have been widely used as load-bearing implants and internal fixation devices because of their excellent mechanical strength and resilience. Among various biometals, titanium (Ti) and its alloys are one of the most widely used materials in the medical field as orthopedic and dental implants, and even vascular/nonvascular stents due to their excellent mechanical properties, chemical stability, and good biocompatibility.
Even though Ti and its alloys have been generally used for biomedical applications, there is still room for improvement because of the mechanical mismatch between bone and implant and low bioactivity. In recent years, much attention has been placed on the design of new Ti alloys with a modified process such as heat treatment and severe plastic deformation for fabricating orthopedic and dental implants with lower elastic moduli in combination with higher strength. On the other hand, some researchers have focused on the surface modification of Ti implants for inducing rapid bone ingrowth.
Porous Ti have also attracted increasing interest, because the 3D pore network can provide a favorable environment for bone ingrowth and possess bone-like mechanical properties. Thus far, considerable efforts have been made to develop new manufacturing techniques for producing porous Ti, such as powder metallurgy and the additive manufacturing method.
Hence, this Special Issue proposes novel results on several aspects of titanium and its alloys for biomedical applications. For this purpose, we warmly welcome submissions, including regular research papers, short communications, and reviews describing current research trends and future perspectives in titanium and its alloys for biomedical applications. The following topics, though not exclusively, fall within the scope of the Special Issue:
- New Ti alloy design for reducing the mechanical mismatch;
- Heat treatment and plastic deformation processing to enhance mechanical properties;
- Surface coating to improve biological responses;
- Manufacturing of porous titanium;
- Additive manufacturing of titanium and its alloy;
- Evaluation of antibacterial properties and cytotoxicity of titanium;
- Characterization of the mechanical behavior of titanium;
- New trends in titanium and its alloy.
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- titanium alloy design
- heat treatment
- plastic deformation processing
- surface coating
- additive manufacturing
- powder metallurgy
- porous titanium
- advanced processing
- mechanical properties
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Discovery of nontoxic Ti-based biomedical alloys having minimum amount of α” and ω-phases using CALPHAD and artificial intelligence
Authors: Rajesh Jha and George S. Dulikravich
Affiliation: Department of Mechanical and Materials Engineering, Multidisciplinary Analysis, Inverse Design, Robust Optimization and Control (MAIDROC) Laboratory, Florida International University, Miami, FL 33174, USA
Abstract: Titanium based alloys have been widely accepted for biomedical applications due to comparatively superior biocompatibility and anticorrosion properties. Efforts are being made to explore new alloys containing elements that are not toxic, as well as developing alloys with Young’s modulus comparable to human bone for avoiding stress shielding. Titanium alloys containing β-phase as the predominant phase is helpful in lowering the Young’s modulus. During development/heat-treatment of Titanium alloys, β-phase can transform into ω-phase. In Ti-based metallic alloys, α” and ω-phases are responsible for degradation of mechanical properties and causing their embrittlement. In this work, we have studied Ti-Zr-Nb-Sn system computationally for exploring novel compositions and temperatures that will be helpful in avoiding/minimizing formation of α” and ω-phases. We studied this alloy system under the framework of CALPHAD approach used for determining phase stability of various phases. Thereafter, we analyzed this phase stability dataset through the application of Artificial Intelligence (AI) algorithms for determining correlation between phase stability of various phases and chemical composition and temperature. We developed artificial neural network models through deep learning approach for various phases and studied correlations within the dataset using Self Organizing Maps (SOM) approach. Through this study, we determined several compositions and temperatures that will be helpful in minimizing and even avoiding formation of α” and ω-phase in Ti-Zr-Nb-Sn system, which is free of toxic elements.