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Article

Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release

Department of Nano-Biomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea
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Academic Editor: Hyun-Do Jung
Metals 2021, 11(6), 899; https://doi.org/10.3390/met11060899
Received: 16 April 2021 / Revised: 27 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Titanium and Its Alloys for Biomedical Applications)
Two-dimensional (2D) graphene oxide (GO) exhibits a high drug loading capacity per unit mass due to its unique structure and hydrophilicity and has been widely researched for drug-delivery systems. Here, we modified the surfaces of metal implants; we applied GO-based coatings that controlled drug loading and release. We used electrophoretic deposition (EPD) to apply the coatings at room temperature. The EPD coatings were analyzed in terms of their components, physical properties such as hardness and hydrophilicity, and in vitro cell tests of their biological properties. Uniform GO-EPD coatings improved surface hydrophilicity and hardness and greatly improved the bone differentiation properties of the metal substrate. Drug loading and release increased greatly compared to when the drug was adsorbed to only the surface of a coating. GO facilitated deposition of a drug-containing coating via EPD, and the surface modification, and drug loading and release, were controlled by the thickness of the coating. View Full-Text
Keywords: graphene oxide; electrophoretic deposition; implant; biomolecule; complex graphene oxide; electrophoretic deposition; implant; biomolecule; complex
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MDPI and ACS Style

Oh, J.-S.; Jang, J.-H.; Lee, E.-J. Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release. Metals 2021, 11, 899. https://doi.org/10.3390/met11060899

AMA Style

Oh J-S, Jang J-H, Lee E-J. Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release. Metals. 2021; 11(6):899. https://doi.org/10.3390/met11060899

Chicago/Turabian Style

Oh, Jun-Sung, Jun-Hwee Jang, and Eun-Jung Lee. 2021. "Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release" Metals 11, no. 6: 899. https://doi.org/10.3390/met11060899

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