Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release
Department of Nano-Biomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Hyun-Do Jung
Metals 2021, 11(6), 899; https://doi.org/10.3390/met11060899
Received: 16 April 2021
/
Revised: 27 May 2021
/
Accepted: 28 May 2021
/
Published: 31 May 2021
(This article belongs to the Special Issue Titanium and Its Alloys for Biomedical Applications)
Two-dimensional (2D) graphene oxide (GO) exhibits a high drug loading capacity per unit mass due to its unique structure and hydrophilicity and has been widely researched for drug-delivery systems. Here, we modified the surfaces of metal implants; we applied GO-based coatings that controlled drug loading and release. We used electrophoretic deposition (EPD) to apply the coatings at room temperature. The EPD coatings were analyzed in terms of their components, physical properties such as hardness and hydrophilicity, and in vitro cell tests of their biological properties. Uniform GO-EPD coatings improved surface hydrophilicity and hardness and greatly improved the bone differentiation properties of the metal substrate. Drug loading and release increased greatly compared to when the drug was adsorbed to only the surface of a coating. GO facilitated deposition of a drug-containing coating via EPD, and the surface modification, and drug loading and release, were controlled by the thickness of the coating.
View Full-Text
Keywords:
graphene oxide; electrophoretic deposition; implant; biomolecule; complex
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MDPI and ACS Style
Oh, J.-S.; Jang, J.-H.; Lee, E.-J. Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release. Metals 2021, 11, 899. https://doi.org/10.3390/met11060899
AMA Style
Oh J-S, Jang J-H, Lee E-J. Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release. Metals. 2021; 11(6):899. https://doi.org/10.3390/met11060899
Chicago/Turabian StyleOh, Jun-Sung, Jun-Hwee Jang, and Eun-Jung Lee. 2021. "Electrophoretic Deposition of a Hybrid Graphene Oxide/Biomolecule Coating Facilitating Controllable Drug Loading and Release" Metals 11, no. 6: 899. https://doi.org/10.3390/met11060899
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
