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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolomics and Lipidomics in MASLD and Related Liver Disorders

edited by Aleksandra Bołdys and Michał Nicze

submission deadline 1 Apr 2026 | Viewed by 89 | Submission Open

Keywords: MASLD; metabolomics; lipidomics; liver disease; biomarkers; metabolic profiling; nonalcoholic fatty liver disease; oxidative stress; mitochondrial dysfunction; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 15 Apr 2026 | Viewed by 391 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases—2nd Edition

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 15 Apr 2026 | Viewed by 106 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

Early-Stage Biomarkers: Metabolomics in Preclinical and Prodromal Disease Detection

edited by

Sonali Mishra

and Preeti Bais

submission deadline 15 Apr 2026 | Viewed by 30 | Submission Open

Keywords: early-stage biomarkers; metabolomics; biomarker validation; untargeted and targeted approaches; cohort studies; multi-omics integration; machine learning / AI; translational research; early disease detection; cancer; neurodegenerative; cerebrovascular; autoimmune; infectious; and psychiatric disorders

(This special issue belongs to the Section Advances in Metabolomics)

Microbial Regulation of Host Metabolism

edited by

Kippeum Lee

submission deadline 15 Apr 2026 | Viewed by 1 | Submission Open

Keywords: gut microbiota-derived metabolites; short-chain fatty acids (SCFAs); gut hormones; bile acid; probi-otics; postbiotics; gut microbiota; microbiome; physiological function; metabolism balance

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 25 Apr 2026 | Viewed by 35 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5137 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 30 Apr 2026 | 1 articles | Viewed by 4524 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2516 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2225 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1645 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 30 Apr 2026 | 1 articles | Viewed by 534 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 30 Apr 2026 | Viewed by 252 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nature’s Vanguard: Secondary Metabolites and Their Emerging Role in the Evolution of Cancer Therapy

edited by

Thiago André Moura Veiga

and

Edgar Julian Paredes-Gamero

submission deadline 30 Apr 2026 | Viewed by 133 | Submission Open

Keywords: natural compounds; cell signaling; cytotoxic effects; mechanism of action; molecular dereplication; plant; fungi; bacteria; marines; molecular docking

(This special issue belongs to the Section Plant Metabolism)

Metabolomics of the Eye and Adnexa—2nd Edition

edited by

Seher Yuksel

and

Igor Butovich

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; meibomian gland dysfunction; age-related macular degeneration; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatography– mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

The Metabolic Genesis of Cardiovascular Disease

edited by Davide Agnoletti

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: metabolic disorder; insulin resistance; inflammation; immune system; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Aging Blueprint: Decoding Biomarkers of Bone and Muscle Health

edited by

Sagar Vyavahare

submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open

Keywords: metabolomics; bone; muscle; aging; biomarker

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Research in Animal Nutrition and Production 2nd Edition

edited by Tietao Zhang and Qingkui Jiang

submission deadline 30 Apr 2026 | Viewed by 9 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metab-olites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 30 Apr 2026 | Viewed by 4 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Harnessing Cancer Metabolism: Unveiling New Therapeutic Approaches and Diagnostic Tools

edited by

Victor H. Villar

, Alejandro Huerta-Uribe and Ruhi Deshmukh

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: cancer; metabolic pathways; apoptosis; treatment

(This special issue belongs to the Section Cell Metabolism)

Computational Modeling of Metabolite-Modulated Cellular Processes

edited by

Md. Altaf-Ul-Amin

and Naoaki Ono

submission deadline 30 Apr 2026 | Submission Open

Keywords: computational metabolomics; metabolic networks; metabolite-regulated cellular processes; natural products; drug discovery; metabolite biomarkers; machine learning algorithms

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Bile Acid Transport and Metabolic Disorders

edited by

Subha Arthur

submission deadline 30 Apr 2026 | Submission Open

Keywords: bile acid transporters; FXR (Farnesoid X Receptor); TGR5; enterohepatic circulation; metabolic regulation; NAFLD (non-alcoholic fatty liver disease); gut microbiota; insulin resistance; bile acids and cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Molecular Mechanisms of Metabolic Pathway Regulation by Phytochemicals

edited by

Carlos Lopez-Ortiz

submission deadline 4 May 2026 | Viewed by 84 | Submission Open

Keywords: phytochemicals; plant metabolism; secondary metabolites; gene expression regulation; metabolomics

(This special issue belongs to the Section Plant Metabolism)

Advances in NMR- and MS-Based Metabolomics and Its Applications

edited by

Anna Maria D’Ursi

and Carmen Marino

submission deadline 5 May 2026 | Viewed by 58 | Submission Open

Keywords: NMR; MS; biofluids; machine learning; tissue; cells cultures; nutraceuticals

(This special issue belongs to the Section Advances in Metabolomics)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 10 May 2026 | Viewed by 39 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolites in Glioma Treatment and Diagnosis

edited by

Rosa Angélica Castillo-Rodríguez

, Gabriela Carrasco-Torres and María Cristina Trejo-Solís

submission deadline 31 May 2026 | Viewed by 100 | Submission Open

Keywords: glioma; metabolites; treatment; diagnosis; prognosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional Epidemiology and Metabolic Disorders, Second Edition

edited by

Kijoon Kim

submission deadline 31 May 2026 | Viewed by 34 | Submission Open

Keywords: nutritional epidemiology; antioxidants; medicinal herbs; functional ingredients; public health

(This special issue belongs to the Section Nutrition and Metabolism)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 30 Jun 2026 | 1 articles | Viewed by 68 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Advancements in Mass Spectrometry Techniques for Metabolomic and Pharmaceutical Analysis

edited by

Xiaowei Song

and Fangling Wu

submission deadline 30 Jun 2026 | Viewed by 50 | Submission Open

Keywords: ambient ionization; mass spectrometry imaging; sample pretreatment; isomer analysis; marker discovery; ion annotation; structural identification; artificial intelligence; multi-omics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Studies in Urinary Diseases

edited by

Dechao Feng

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: metabolomics; lipidomics; biomarkers; chronic kidney disease (CKD); acute kidney injury (AKI); urolithiasis (kidney stones); bladder cancer; prostate cancer; diabetic nephropathy; polycystic kidney disease; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Endothelial Metabolism in Vascular Development and Diseases

edited by

Pengchun Yu

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: cellular metabolism; metabolites; metabolic network; blood endothelial cells; lymphatic endothelial cells; blood vessel development; lymphatic vascular development; vascular disease; cancer; ocular disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Lipid Metabolism in Health and Disease

edited by

Mónica Narváez-Rivas

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: lipid metabolism; lipidomics; dyslipidemia; mass spectrometry; lipid biomarkers; lipid signaling; therapeutic targets; bioinformatics; clinical lipidomics

(This special issue belongs to the Section Lipid Metabolism)

Novel Methods of Mass Spectrometry Imaging Towards Biomedical and Environmental Applications

edited by