Nutritional Intervention and Metabolic Health: Carbohydrates and Keto Diet
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 30 July 2026 | Viewed by 10
Special Issue Editor
Interests: type 2 diabetes mellitus; diet; glycaemic control; insulin sensitivity; metabolic health; dietary interventions; nutritional strategies; diabetes management; lifestyle factors; T2DM prevention
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The optimal macronutrient composition for maintaining metabolic health remains a subject of active scientific discussion, particularly regarding the comparative effects of low-fat and high-fat ketogenic diets (KDs). Recent evidence presents mixed outcomes. A 2023 umbrella review reported improvements in glycaemic control, weight management, and other cardiometabolic markers with KDs, but also highlighted an increase in low-density lipoprotein (LDL) cholesterol. Similarly, a 2022 meta-analysis observed elevated total and LDL cholesterol in individuals following very-low-carbohydrate diets compared to control groups. These findings emphasise the complex relationship among carbohydrate restriction, lipid metabolism, and long-term metabolic outcomes.
This Special Issue aims to examine how variations in carbohydrate intake and ketogenic dietary patterns influence glucose and lipid metabolism, insulin resistance, and cardiometabolic risk. We welcome studies addressing obesity, type 2 diabetes, and cardiovascular disease, as well as research exploring gut microbiota interactions and their role in metabolic regulation. Multi-omics approaches integrating genetic, epigenetic, and microbial determinants are encouraged. By combining molecular insights with clinical evidence, this Special Issue seeks to advance personalised nutrition strategies that promote metabolic resilience and support the prevention of chronic metabolic disorders.
Dr. Louise Lu
Guest Editor
Manuscript Submission Information
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Keywords
- metabolic health
- carbohydrate metabolism
- ketogenic diet
- personalized nutrition
- glycaemic control
- insulin sensitivity
- lipid profiles
- gut microbiome
- nutrient-sensing pathways
- epigenetic modifications
- personalized postprandial glucose response
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