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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Plant and Microbial Metabolic Engineering

edited by

Filippos Ververidis

and

Emmanouil Trantas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 728 | Submission Open

Keywords: plant metabolic engineering; primary and secondary metabolism; plant synthetic biology; natural products; molecular farming; molecular breeding; food security

(This special issue belongs to the Section Plant Metabolism)

Metabolic Regulation of Reproductive Physiology in Livestock Species

edited by

Gabriele Brecchia

Giulio Curone

and Stella Agradi

submission deadline 31 Dec 2025 | Viewed by 440 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient me-tabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention

edited by Songhua Hu, Yahui Wang and

Daniel Oscar Cicero

submission deadline 31 Dec 2025 | Viewed by 366 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; metabolic plasticity; cancer heterogeneity; therapeutic resistance; tumor microenvironment; combination therapies

(This special issue belongs to the Section Cell Metabolism)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 31 Dec 2025 | Viewed by 335 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Mitochondrial Metabolism, Redox State and Immunology in Cancer

edited by

Alfredo Cruz-Gregorio

and

Gladis Fragoso

submission deadline 31 Dec 2025 | Viewed by 273 | Submission Open

Keywords: immune system; mitochondria; redox state; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites in Animal Nutrition and Physiological Regulations Under Stress Conditions

edited by

Hieu Huu Le

and

Majid Shakeri

submission deadline 31 Dec 2025 | Viewed by 241 | Submission Open

Keywords: metabolic; nutrition; amino acids; meat quality; metabolites; fatty acids; non-esterified fatty acids (NEFA); physiology; metabolism; dietary supplementation

(This special issue belongs to the Section Animal Metabolism)

Metabolomics and MASLD: Pathways, Biomarkers, and Clinical Insights

edited by

Amedeo Lonardo

and

Ralf Weiskirchen

submission deadline 31 Dec 2025 | Viewed by 228 | Submission Open

Keywords: amino acids; bile acids; cardiovascular disease; cholesterol; ceramides; cirrhosis; diabetes; eicosanoids; HIV; hyper-tension; insulin resistance; lipidome; lipidomics; lipotoxicity; liver fibrosis; MASLD/MASH; metabolome; metabolomics; microbiome; NAFLD/NASH omics; obesity; precision medicine; phospholipids; sphingolipids; triglycerides; SCFA; tar-geted metabolomics; TMAO; uric acid; HCC; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Women’s Special Issue Series: Metabolomic Profiling Technology

edited by

Thusitha W. Rupasinghe

and

RuAngelie Edrada-Ebel

submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open

Keywords: metabolomics; metabolomic profiling technology; metabolism; analytical chemistry; NMR; mass spectrometry

(This special issue belongs to the Section Metabolomic Profiling Technology)

Obesity and Metabolic Syndrome in Children: Insights, Interventions and Emerging Perspectives, 2nd Edition

edited by

Teofana Otilia Bizerea-Moga

and Rade Vukovic

submission deadline 31 Dec 2025 | Viewed by 134 | Submission Open

Keywords: metabolic syndrome in children; childhood obesity; hypertension; glucose tolerance; insulin resistance; nutritional status; metabolomics; oxidative stress; trace elements— selenium

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity, Hormones, and Metabolic Complications in Pregnancy

edited by

Angélica Saraí Jiménez-Osorio

Diego Estrada-Luna

and

Jennifer W. Hill

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: obesity; gestational weight gain; hormones; oxidative stress; inflammation; metabolic complications of pregnancy; neonatal complications; childhood health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advancing Metabolic/Microbial Biomarker Applications in Disease Prevention, Diagnosis and Public Health

edited by

Pengcheng Tu

and

Bei Gao

submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open

Keywords: biomarkers; disease processes; gut microbiome; multi-omics; metabolic indicators; clinical applications

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic and Lipidomic Reprogramming in Cancer: Mechanisms and Therapeutic Potential

edited by

Sara Vicente-Muñoz

and

Mariaelena Pistoni

submission deadline 31 Dec 2025 | Viewed by 79 | Submission Open

Keywords: cancer hallmarks; metabolomics; lipidomics; stable isotopes; biomarkers; therapeutic targets; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

MicroRNAs in Lipid Metabolism

edited by Pablo Fernández-Tussy

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: microRNAs; lipid metabolism; lipoproteins; obesity; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Effects of Phytochemicals on Human Metabolism

edited by

Henrique Cerqueira

and

Eric Gumpricht

submission deadline 31 Dec 2025 | Viewed by 74 | Submission Open

Keywords: phytochemistry; bioactive compounds; metabolism; nutritional interventions; energy balance; oxidative stress; inflammation

(This special issue belongs to the Section Nutrition and Metabolism)

Application of Urinary Metabolomics in Early Disease Detection

edited by

Casey Burton

submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open

Keywords: urinary metabolomics; biomarkers; early disease detection; analytical method development; therapeutic response monitoring

(This special issue belongs to the Section Advances in Metabolomics)

Role of Cell Metabolism in Infective Diseases

edited by

Chongshan Dai

submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open

Keywords: metabolites; immunology; drug therapy; new compounds; cellular metabolism; infectious diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Chemical Exposure on Endocrine and Reproductive Functions, 2nd Edition

edited by Renata Marino Romano and Caroline Serrano-Nascimento

submission deadline 31 Dec 2025 | Viewed by 29 | Submission Open

Keywords: endocrine-disrupting chemicals exposure impact on metabolic diseases; reproductive failure; infertility; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Food Intake and Bioactive Metabolism in Humans

edited by Anallely López-Yerena and Emily P. Laveriano Santos

submission deadline 15 Jan 2026 | 1 articles | Viewed by 949 | Submission Open

Keywords: bioactive compounds; phytochemical; carotenoids; polyphenols; oxylipins; gut microbiota; bioavailability; personalized nutrition; functional foods; disease prevention

(This special issue belongs to the Section Nutrition and Metabolism)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 15 Jan 2026 | Viewed by 46 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Intestinal Health and Metabolites in Farm Animals—2nd Edition

edited by

Qian Jiang

and Junquan Tian

submission deadline 19 Jan 2026 | Viewed by 45 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Interactions between Exercise Physiology and Metabolism

edited by

Lijing Gong

and Enming Zhang

submission deadline 31 Jan 2026 | 5 articles | Viewed by 6755 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Fish

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6498 | Submission Open

Keywords: fish; metabolism; nutrition; feed additives; lipid; protein; requirements

(This special issue belongs to the Section Animal Metabolism)

Metabolomic Fingerprinting: Challenges and Opportunities

edited by Christina Virgiliou and

Olga-Angeliki Begou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3555 | Submission Open

Keywords: metabolomics/metabonomics; mass spectrometry; metabolome; HRMS; hyphenated techniques

(This special issue belongs to the Section Integrative Metabolomics)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2837 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Comprehensive Insights into Metabolic Pathways: Genome-Scale Modeling Techniques

edited by

Priyanka Baloni

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2376 | Submission Open

Keywords: metabolism; systems biology; genome-scale metabolic modeling; multi-omics data; data integration; data analysis; metabolic regulation; biomarker; drug targets

(This special issue belongs to the Section Advances in Metabolomics)

Psoriasis and Metabolic Syndrome

edited by Anna Baran

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1858 | Submission Open

Keywords: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids

(This special issue belongs to the Section Lipid Metabolism)

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1786 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

The Impact of Polyphenols on Metabolic Health and Disease

edited by

Si Qin

and Kozue Sakao

submission deadline 31 Jan 2026 | Viewed by 347 | Submission Open

Keywords: polyphenols; metabolic diseases; molecular mechanisms; intervention; AI

(This special issue belongs to the Section Nutrition and Metabolism)

Artificial Intelligence and Machine Learning in Metabolomics

edited by

Robert Winkler

submission deadline 31 Jan 2026 | Viewed by 134 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; metabolomics; integrative approaches

(This special issue belongs to the Section Integrative Metabolomics)

Connections Between Nutrition, Epidemiology, and Metabolism

edited by

Kijoon Kim

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: nutritional epidemiology; metabolism; antioxidants; medicinal herbs; functional ingredients; chronic disease; public health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Syndrome and Non-Alcoholic Liver Disease—Second Edition

edited by

Mircea-Catalin Fortofoiu

submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open

Keywords: metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); insulin resistance; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; hepatic steatosis; cardiovascular risk

(This special issue belongs to the Section Lipid Metabolism)

Plant Metabolome and Metabolomics

edited by

Subhash Minocha

submission deadline 31 Jan 2026 | Viewed by 71 | Submission Open

Keywords: metabolomics; LC/MS-based metabolomics; plant science; metabolic pathways; biotechnology applications; sustainable agriculture

Metabolic Crosstalk in the Tumor Microenvironment

edited by

Drenka Trivanovic

Ristic Biljana

and

Vesna M. Ćorić

submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open

Keywords: cancer; oncometabolites; tumor microenvironment; metabolic crosstalk

(This special issue belongs to the Section Cell Metabolism)

Zebrafish Models in the Study of Diabetes and Metabolic Dysfunction

edited by Liqing Zang

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: zebrafish; diabetes; obesity; metabolic dysfunction; insulin resistance; hyperglycemia; lipid metabolism; drug screening; nutraceuticals; gene editing; high-fat diet; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine

edited by

Silvia Valentinuzzi

and

Troy D. Wood

submission deadline 31 Jan 2026 | Viewed by 47 | Submission Open

Keywords: metabolomics; biomarker discovery; mass spectrometry; omics integration; molecular signatures; precision medicine

(This special issue belongs to the Section Integrative Metabolomics)

Nutritional Interventions and Lipid Metabolism

edited by

Cecilia Bender

and

Mariano Stornaiuolo

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: lipid metabolism; nutritional interventions; dietary fats; bioactive compounds; functional foods; chronic diseases; nutrigenomics; weight management; inflammation; personalized nutrition

(This special issue belongs to the Section Lipid Metabolism)

Metabolism of Bioactives and Natural Products: 2nd Edition

edited by Kamila Misiakiewicz-Has, Barbara Wiszniewska and

Sylwia Rzeszotek

submission deadline 31 Jan 2026 | Viewed by 38 | Submission Open

Keywords: natural products; bioactive; medicinal plants; phytochemicals; isoflavones; triterpenes; coumarins; alkaloids; prebiotics; carotenoids; polyphenols; organosulfur compounds

(This special issue belongs to the Section Nutrition and Metabolism)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 31 Jan 2026 | Viewed by 37 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications

edited by Raja Gopal Reddy Mooli,

Hang Cheng

and

Nathan Lanning

submission deadline 31 Jan 2026 | Viewed by 37 | Submission Open

Keywords: oxygen; hypoxia; metabolism; Hypoxia Inducible Factors (HIFs); prolyl hydroxylase domain-containing enzymes (PHDs); metabolic regulation; glucose metabolism; fatty acid metabolism; TCA cycle; metabolites

(This special issue belongs to the Section Cell Metabolism)

Bioenergetics in Diet and Metabolism: Nutritional Pathways to Health

edited by

Cennet Yıldız

and

Xinhui Wang

submission deadline 31 Jan 2026 | Submission Open

Keywords: bioenergetics; metabolic efficiency; energy metabolism; nutritional interventions; diet-induced thermogenesis; macronutrient composition; metabolic health; metabolic disorders; biothermodynamics; entropy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Changes During Pre- and Post-Harvest Fruit and Vegetable Decay, Ripening and Senescence—2nd Edition

edited by

Analía Concellón

and

María José Zaro

submission deadline 2 Feb 2026 | Viewed by 72 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 10 Feb 2026 | Viewed by 140 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Role of Lipid Metabolism in Cardiovascular Health

edited by Irma Magaly Rivas Serna and

Timothy O'Toole

submission deadline 16 Feb 2026 | Viewed by 118 | Submission Open

Keywords: metabolism of lipids; lipid classes; lipid species; cardiovascular health; lipidomics; cardiometabolic disease; cardiovascular disease; atherosclerosis; dyslipidemia; phospholipids; glyceride lipids; non-glyceride lipids; sphingolipids; ceramides; cardiac biomarkers; mechanism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Novel Approaches for Metabolomics in Drugs and Biomarkers Discovery: 2nd Edition

edited by

Cecília R.C. Calado

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2705 | Submission Open

Keywords: metabolomics; drugs discovery; biomarkers discovery; diagnostic; prognosis

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

edited by

Jože Starič

and

Marko R. Cincovic

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1897 | Submission Open

Keywords: feed supplements; metabolic profiles; metabolic biomarkers; metabolic stress; metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

edited by

Samuel Treviño

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1564 | Submission Open

Keywords: murine models; metabolic diseases; molecular mechanisms; biochemical pathways; pharmacological strategies; interactome; comorbidities; metabolic phenotypes; novel techniques

(This special issue belongs to the Section Nutrition and Metabolism)

Synthetic Biology Approaches for Expanding the Metabolic Capabilities of E. coli

edited by

Angelo Bañares

and Kei Anne Baritugo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 824 | Submission Open

Keywords: synthetic biology; Escherichia coli (E. coli); metabolic engineering; genome editing (crispr-cas9); novel metabolic pathways; high-value chemicals; biofuels; bioremediation; environmental sensing; microbial cell factory

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications

edited by Adam D. Kennedy and Greg Michelotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: metabolomics; precision medicine; clinical disease; biomarkers; therapeutics; clinical metabolomics; nutrition; functional medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Integration of Proteomics and Metabolomics: A Comprehensive Approach to Omics Research

edited by

Marcel Kwiatkowski

submission deadline 28 Feb 2026 | Viewed by 280 | Submission Open

Keywords: metabolomics; proteomics; metabolic flux analysis; PTMs; cross-omics; data integration; systems biology; computational modelling

(This special issue belongs to the Section Advances in Metabolomics)

Pharmacodynamics and Innovative Therapeutic Strategies for Metabolic Disorders

edited by

Josué V. Espinosa-Juárez

Osmar Antonio Jaramillo-Morales

and

Victor Gault

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: pharmacology; experimental therapeutics; metabolic diseases; drug development; therapeutic innovations; metabolic pathways; pharmacodynamics; disease management

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

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