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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sex Differences in Physical Exercise and Dietary Habits Effects on Metabolic Health

edited by Hannah Cabre and

Adam M. Gonzalez

submission deadline 28 Nov 2025 | 3 articles | Viewed by 3125 | Submission Open

Keywords: sex differences; metabolomics; metabolites; menstrual cycle; aging; exercise performance; nutrition intervention; cardiometabolic

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity

edited by

Alberto Jorge Oliveira Lopes

Antônio José Cantanhede Filho

and Claúdia Quintino Da Rocha

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5415 | Submission Open

Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application

edited by Eiji Kutoh and

Shengshuai Shan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 5115 | Submission Open

Keywords: metabolic biomarkers; type 2 diabetes (T2DM); glucose metabolism; insulin resistance; lipid profiles; diagnosis and prognosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5094 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Environmental Metabolites Insights into Health and Disease

edited by

Yu Sun

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5085 | Submission Open

Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways

(This special issue belongs to the Section Environmental Metabolomics)

One-Carbon Metabolism in Pregnant Women, Fetuses, and Infants

edited by

Yoshinori Kubo

and

Hikaru Hori

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2168 | Submission Open

Keywords: folate cycle (5-methyltetrahydrofolate; folic acid; vitamin B12; serine; glycine); methionine cycle (homocysteine; methionine; S-adenosylmethionine; S-adenosylhomocysteine); choline metabolic pathway (betaine; choline); trans-sulfuration pathway (cysteine; taurine; vitamin B6); epigenetics; developmental origins of health and disease (DOHaD)

(This special issue belongs to the Section Nutrition and Metabolism)

Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends

edited by

Mohammad Mehdi Banoei

and

Mehdi Mirsaeidi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2153 | Submission Open

Keywords: mass spectrometry-based metabolomics; targeted metabolomics; health and disease; precision medi-cine; biomarker discovery; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1809 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

Environmental Exposure and Its Effects on Cardio-Respiratory and Metabolic Health

edited by

Kristine McGrath

and Tatt Jhong Haw

submission deadline 30 Nov 2025 | 1 articles | Viewed by 954 | Submission Open

Keywords: environmental factors; pollution; cardiovascular; cardiometabolic risk factor; biomarkers; mechanisms; cardio-oncology; cardio-respiratory

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Phenological Regulation of Secondary Metabolism

edited by

Iván De-la-Cruz-Chacón

, Alma Rosa González-Esquinca and

Xin Fang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 783 | Submission Open

Keywords: phenological fluctuations; metabolites’ phenological fluctuations; secondary metabolites; natural products; specialized metabolites

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Personalized Medicine

edited by

Angom Ramcharan Singh

submission deadline 30 Nov 2025 | 1 articles | Viewed by 764 | Submission Open

Keywords: metabolomics; personalized medicine; biomarkers; precision health; disease stratification; metabolic profiling; NMR spectroscopy; mass spectrometry; therapeutic response; systems biology

(This special issue belongs to the Section Advances in Metabolomics)

The Role of Isotope Tracers in Investigating Metabolic Disorders

edited by Nadezda Khodorova

submission deadline 30 Nov 2025 | Viewed by 337 | Submission Open

Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests

(This special issue belongs to the Section Metabolomic Profiling Technology)

Investigating the Impact of Teas on Metabolic Disorders: Insights into Underlying Mechanisms and Therapeutic Potential

edited by

Ran Wei

and

Michał Tomczyk

submission deadline 30 Nov 2025 | Viewed by 194 | Submission Open

Keywords: teas; metabolic disorders; mechanism of action; therapeutic potential; diabetes; obesity; cardiovascular diseases; biochemical properties; clinical studies; therapeutic strategies

(This special issue belongs to the Section Nutrition and Metabolism)

Imaging and Spectroscopic Based Methods to Understand Cancer Metabolism and Biology 2025

edited by

Madhu Basetti

submission deadline 30 Nov 2025 | Viewed by 188 | Submission Open

Keywords: PET; CT; MRI; NMR; molecular imaging; optical imaging; opto-acoustic imaging; Raman imag-ing and spectroscopy; mass spectroscopy imaging; metabolic pathways; theranostic imaging; machine learning; deep learning; artificial intelligence; image analysis; tumors; cancer; cancer metabolism; cancer biology; tumor microenvironment; tumor heterogeneity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Future Perspective on Screening and Diagnosis of Inborn Errors of Metabolism

edited by Luiz Carlos Santana-Da-Silva, Olga Yaneth Echeverri-Peña and

Angela J. Espejo-Mojica

submission deadline 30 Nov 2025 | Viewed by 185 | Submission Open

Keywords: inborn errors of metabolism (IEM); genetic disorders; diagnostics; biomarkers; omics sciences; imaging techniques (MRS; PET); molecular techniques (NGS; gene editing); personalized medi-cine; early detection

Exposome and Metabolic Effects: Neurological Implications of Environmental Pollutants

edited by

Roberta Zupo

and Fabio Castellana

submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open

Keywords: exposome; environmental pollutants; metabolic effects; neurological implications; neurodegenerative diseases; cognitive dysfunction; brain metabolism; toxins; environmental health; developmental disorders; neurobiology; genetic predisposition; preventive strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Proteomics and Metabolomics in Human Health and Disease

edited by

Michele Costanzo

and

Margherita Ruoppolo

submission deadline 30 Nov 2025 | Viewed by 141 | Submission Open

Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence

(This special issue belongs to the Section Advances in Metabolomics)

Autophagy and Antioxidant Pathways in Neurodegenerative Diseases

edited by

Federica Armeli

and

Rita Businaro

submission deadline 30 Nov 2025 | Viewed by 133 | Submission Open

Keywords: neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; autophagy; neuroinflammation; oxidative stress; antioxidant pathways; neuroprotection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Disease Mechanisms and Drug Targets, 2nd Edition

edited by

Kefeng Li

submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open

Keywords: metabolomics; disease mechanism; drug target; biomarker; disease prediction

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics in Breath Biomarker Discovery

edited by Waqar Ahmed

submission deadline 30 Nov 2025 | Viewed by 102 | Submission Open

Keywords: exhaled breath volatiles; metabolomics; biomarkers; volatile organic compounds

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Gut Microbiome Metabolomics

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 1 Dec 2025 | 2 articles | Viewed by 2626 | Submission Open

Keywords: gut microbiome– host interaction; cross talk; metabolomics; omics- technologies; microbiome signatures; new diagnostic tools; novel therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Respiratory, Cardiovascular and Metabolic Disorders

edited by Joaquim Gea

submission deadline 1 Dec 2025 | Viewed by 140 | Submission Open

Keywords: metabolomics; small molecules; mass spectrometry; NMR; personalized medicine; biomarkers; car-diovascular disorders; respiratory diseases; endocrine metabolic abnormalities

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Plant Defence, 2nd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 5 Dec 2025 | 2 articles | Viewed by 1319 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiles in Inflammatory Diseases

edited by Rodica Pădureanu and

Ionut Donoiu

submission deadline 15 Dec 2025 | 2 articles | Viewed by 1669 | Submission Open

Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Dec 2025 | 1 articles | Viewed by 866 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Plant Natural Products Research, 2nd Edition

edited by

Junsong Wang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 802 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Exploring Uric Acid and Beyond

edited by

Pietro Cirillo

and

Claudio Borghi

submission deadline 31 Dec 2025 | 7 articles | Viewed by 19218 | Submission Open

Keywords: uric acid; cardiovascular risk; kidney disease; obesity; diabetes; lipid metabolism; immune programming

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Meeting the Challenge of Metabolomics Analysis by Using Multidimensional Gas Chromatography with Mass Spectrometry

edited by

Yong Foo Wong

and

Philip J. Marriott

submission deadline 31 Dec 2025 | 6 articles | Viewed by 16993 | Submission Open

Keywords: GC× GC; MDGC; metabolites; high-resolution mass spectrometry; metabolite profiling; metabolite fingerprinting; biomarker; plant secondary compounds; disease diagnosis

(This special issue belongs to the Section Metabolomic Profiling Technology)

Brain Metabolic Alterations in Neurodegenerative Diseases

edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro

submission deadline 31 Dec 2025 | 3 articles | Viewed by 12209 | Submission Open

Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 31 Dec 2025 | 1 articles | Viewed by 6913 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Signaling, Therapeutics and Controlled-Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3513 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3370 | Submission Open

Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease

(This special issue belongs to the Section Integrative Metabolomics)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3210 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2682 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Lipid Metabolism Disorders in Obesity

edited by

Klaudia Sztolsztener

and

Elzbieta Supruniuk

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2508 | Submission Open

Keywords: fatty liver diseases; overweight and obesity; cardiometabolic risks; lipid metabolism; metabolic syndrome; adipose tissue

(This special issue belongs to the Section Lipid Metabolism)

Energy Metabolism in Brown Adipose Tissue

edited by

Chuanhai Zhang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2468 | Submission Open

Keywords: energy metabolism; thermogenic fat tissue; metabolites; mitochondrial function; ER stress

(This special issue belongs to the Section Cell Metabolism)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1935 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

Metabolomics in Neurodegenerative Diseases, 2nd Edition

edited by

Stewart Francis Graham

and Nazia M. Saiyed

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1745 | Submission Open

Keywords: neurodegenerative disease; Alzheimer’ s; Parkinson’ s; Huntington’ s; ALS; neurodegeneration; bi-omarkers; metabolism; etiology; pathophysiology; biochemistry

(This special issue belongs to the Section Cell Metabolism)

Advancing Metabolite Biomarkers in Neurodegenerative Disease: Discovery, Integration, and Therapeutic Potential

edited by Robert Logan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1237 | Submission Open

Keywords: biomarkers; neurodegeneration; metabolites; metabolic pathways; metabolomic; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Cell Metabolism)

Primary Hyperparathyroidism: Mechanisms and Treatment

edited by Elena Castellano and

Federica Saponaro

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1224 | Submission Open

Keywords: primary pyperparathyroidism; mechanism; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic and Endocrine Adaptations in Aquatic Animals

edited by

Anapaula Sommer Vinagre

, Luiz C. Kucharski and Mariana Leivas Müller Hoff

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1165 | Submission Open

Keywords: aquatic animal metabolism; animal endocrinology; fish metabolism; fish endocrinology; crustacean metabolism; crustacean endocrinology

(This special issue belongs to the Section Animal Metabolism)

Advances in Plant and Microbial Metabolic Engineering

edited by

Filippos Ververidis

and

Emmanouil Trantas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1100 | Submission Open

Keywords: plant metabolic engineering; primary and secondary metabolism; plant synthetic biology; natural products; molecular farming; molecular breeding; food security

(This special issue belongs to the Section Plant Metabolism)

Exploring Innovations in Secondary Metabolites and Their Effects on Pain, Inflammation and Metabolic Syndrome

edited by

Raquel Cariño-Cortés

and

Mario Ortiz

submission deadline 31 Dec 2025 | 1 articles | Viewed by 977 | Submission Open

Keywords: secondary metabolites; pain; inflammation; chronic-degenerative diseases; chemoprevention; metabolic syndrome; plants

(This special issue belongs to the Section Plant Metabolism)

Advancing Metabolic/Microbial Biomarker Applications in Disease Prevention, Diagnosis and Public Health

edited by

Pengcheng Tu

and

Bei Gao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 748 | Submission Open

Keywords: biomarkers; disease processes; gut microbiome; multi-omics; metabolic indicators; clinical applications

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Regulation of Reproductive Physiology in Livestock Species

edited by

Gabriele Brecchia

Giulio Curone

and Stella Agradi

submission deadline 31 Dec 2025 | Viewed by 498 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient me-tabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention

edited by Songhua Hu, Yahui Wang and

Daniel Oscar Cicero

submission deadline 31 Dec 2025 | Viewed by 426 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; metabolic plasticity; cancer heterogeneity; therapeutic resistance; tumor microenvironment; combination therapies

(This special issue belongs to the Section Cell Metabolism)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 31 Dec 2025 | Viewed by 398 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Metabolomics and MASLD: Pathways, Biomarkers, and Clinical Insights

edited by

Amedeo Lonardo

and

Ralf Weiskirchen

submission deadline 31 Dec 2025 | Viewed by 333 | Submission Open

Keywords: amino acids; bile acids; cardiovascular disease; cholesterol; ceramides; cirrhosis; diabetes; eicosanoids; HIV; hyper-tension; insulin resistance; lipidome; lipidomics; lipotoxicity; liver fibrosis; MASLD/MASH; metabolome; metabolomics; microbiome; NAFLD/NASH omics; obesity; precision medicine; phospholipids; sphingolipids; triglycerides; SCFA; tar-geted metabolomics; TMAO; uric acid; HCC; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites in Animal Nutrition and Physiological Regulations Under Stress Conditions

edited by

Hieu Huu Le

and

Majid Shakeri

submission deadline 31 Dec 2025 | Viewed by 304 | Submission Open

Keywords: metabolic; nutrition; amino acids; meat quality; metabolites; fatty acids; non-esterified fatty acids (NEFA); physiology; metabolism; dietary supplementation

(This special issue belongs to the Section Animal Metabolism)

Mitochondrial Metabolism, Redox State and Immunology in Cancer

edited by