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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hyperlipidemia Related Endocrine Disease and Cancer in Human and Animal

edited by

Kyuhyung Choi

submission deadline 31 Aug 2025 | Viewed by 195 | Submission Open

Keywords: hyperlipidemia; diabetes mellitus; Cushing’ s disease; pancreatitis; hepatocellular carcinoma; mammary gland tumor; colorectal cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Amino Acid Metabolism in Angiogenesis

edited by Roxana Elena Oberkersch and

Teodoro Bottiglieri

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: amino acid metabolism; endothelial cells; angiogenesis; metabolic pathways; cellular crosstalk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Effects of Nutrition Intake on Pet Metabolism

edited by

Giulia Pignataro

submission deadline 1 Sep 2025 | 1 articles | Viewed by 695 | Submission Open

Keywords: pet nutrition; pet food; nutraceuticals; clinical dietetics; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 15 Sep 2025 | 1 articles | Viewed by 607 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 15 Sep 2025 | Viewed by 132 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

Metabolomics in Chronic Disease

edited by Xiaoyu Che

submission deadline 20 Sep 2025 | Viewed by 443 | Submission Open

Keywords: metabolomics; chronic diseases; multi-omics; bioinformatics; biomarker discovery; system biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects

edited by

Woojin Kim

submission deadline 20 Sep 2025 | Viewed by 372 | Submission Open

Keywords: chemotherapy-induced side effects; pain; nausea and vomiting; neutropenia

(This special issue belongs to the Section Plant Metabolism)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 20 Sep 2025 | Viewed by 265 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Multi-Omics Dissection of EMT-Driven Cancer Metabolism in Drug Resistance and Metastasis

edited by Lei Huang

submission deadline 20 Sep 2025 | Viewed by 122 | Submission Open

Keywords: multi-omics; EMT; drug-resistant; metastasis; metabolism-driven therapies

(This special issue belongs to the Section Cell Metabolism)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Sep 2025 | 7 articles | Viewed by 15916 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites

edited by

José Iván Serrano-Contreras

submission deadline 30 Sep 2025 | 1 articles | Viewed by 9584 | Submission Open

Keywords: foodomics; nutrimetabolomics; phytochemicals; food chemistry; food analysis; dark matter in diet; nutritional dark matter; nutritional hormesis; untargeted/targeted analysis

(This special issue belongs to the Section Food Metabolomics)

Unlocking Nature's Toolbox: Advances in Plant Metabolites Identification

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Sep 2025 | 6 articles | Viewed by 6924 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Advances in Metabolomics and Multi-Omics Integration

edited by

Kurt K. Zhang

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6633 | Submission Open

Keywords: metabolomics; cellular metabolism; multi-omics; metabolites; molecular interaction; cell– cell cross-talk

(This special issue belongs to the Section Integrative Metabolomics)

Analysis of Specialized Metabolites in Natural Products

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 30 Sep 2025 | 5 articles | Viewed by 6603 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Insights into Metabolism, Diagnostics and Therapeutics of Cancer and Tumor Microenvironment by NMR Spectroscopy

edited by

Shivanand M. Pudakalakatti

and

Pratip K. Bhattacharya

submission deadline 30 Sep 2025 | 2 articles | Viewed by 5032 | Submission Open

Keywords: cancer metabolism; early diagnosis; therapeutic intervention; NMR spectroscopy; instrument development; pulse sequence design; metabolites; software for metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Nuclear Magnetic Resonance-Powered Metabolomics: Progress and Future Prospects

edited by Abhinav Dubey

submission deadline 30 Sep 2025 | 4 articles | Viewed by 3792 | Submission Open

Keywords: solution-state NMR; metabolism; clinical studies; biomarker discovery; high-throughput data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3531 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine

edited by

Katarzyna Jakimiuk

and Arkadiusz Surażyński

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2845 | Submission Open

Keywords: natural plant products; biological and pharmacological activity; isolation; disease prevention and treatment; natural plant drug discovery

(This special issue belongs to the Section Plant Metabolism)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2460 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Adrenal Neuroendocrine System and Cardiometabolic Health

edited by

Moe Thuzar

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1897 | Submission Open

Keywords: adrenal; metabolic syndrome; cardiovascular health; glucocorticoid; mineralocorticoid

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Technology for Metabolic Profiling

edited by Gregory Hamm,

Laura Cole

and Lin Wang

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1570 | Submission Open

Keywords: metabolomics; lipidomic; high-resolution mass spectrometry; untargeted and targeted; data processing; pathway mapping; fluxomic

(This special issue belongs to the Section Metabolomic Profiling Technology)

Application of NMR in Food Metabolomics

edited by Charalambos Fotakis and

Maria Zervou

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1451 | Submission Open

Keywords: food items; NMR; food metabolomics; quality assurance; geographical origin; authenticity

(This special issue belongs to the Section Metabolomic Profiling Technology)

Amino Acid Metabolism and Function in Human Diseases

edited by Jolanta Bugajska and Krystyna Sztefko

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1355 | Submission Open

Keywords: free amino acids; civilization diseases; obesity; diabetes; liver disease; heart diseases; reference intervals

(This special issue belongs to the Section Cell Metabolism)

Role of Metabolic Factors and Their Interactions on Diabetes and Its Complications

edited by Yun Shen

submission deadline 30 Sep 2025 | Viewed by 561 | Submission Open

Keywords: metabolic risk factors; diabetes comorbidities; bioinformatics; machine learning; multi-omics integration; cardiovascular disease; dyslipidemia; insulin resistance; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipidomic Signatures in Pediatric Metabolic Disorders

edited by

Mónica Narváez-Rivas

submission deadline 30 Sep 2025 | Viewed by 494 | Submission Open

Keywords: lipidomics; lipids; mass spectrometry; pediatric population; therapeutic targets; biomarkers; metabolic disorder

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Sep 2025 | Viewed by 323 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Changes in Diet-Mediated Inflammatory Diseases

edited by

Beatrice Dufrusine

submission deadline 30 Sep 2025 | Viewed by 235 | Submission Open

Keywords: nutrition; Westernized diet; inflammation; immune system; cancer; metabolic reprogramming; au-toimmune disease; obesity; allergies; inflammatory bowel diseases; celiac disease

(This special issue belongs to the Section Nutrition and Metabolism)

Circadian System Associated with Lipid Metabolism and Metabolic Diseases

edited by

Xiaoyue Pan

submission deadline 30 Sep 2025 | Viewed by 190 | Submission Open

Keywords: circadian rhythm; circadian clock; lipid transport; lipid oxidation; lipid synthesis; lipid metabolism; lipoprotein

(This special issue belongs to the Section Cell Metabolism)

Biomarkers and Human Blood Metabolites 2025

edited by

Mina Hur

submission deadline 30 Sep 2025 | Viewed by 179 | Submission Open

Keywords: blood metabolites as human biomarkers; identification of disease and non-disease biomarkers; understanding the pathogenesis of the diseases through metabolites; physiological response against environmental stress or stimuli; exposure to toxin or chemical drugs; lifestyle; nutrition; and genetic or epigenetic factors

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 10 Oct 2025 | 2 articles | Viewed by 3265 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

edited by

Paola Maycotte

and

Álvaro Marín-Hernández

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3739 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria; autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 15 Oct 2025 | Viewed by 166 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 30 Oct 2025 | 3 articles | Viewed by 3598 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nutritional and Metabolic Influences on Animal Growth and Reproduction

edited by

Zhipeng Li

and

Baichuan Deng

submission deadline 30 Oct 2025 | 4 articles | Viewed by 3472 | Submission Open

Keywords: metabolites; nutritional and metabolic influences; animal development; meat quality; dairy science; animal reproduction

(This special issue belongs to the Section Animal Metabolism)

Nutrition and Metabolism in Human Diseases 2nd Edition

edited by

Xinhui Wang

submission deadline 31 Oct 2025 | 4 articles | Viewed by 7277 | Submission Open

Keywords: nutrition; metabolism; nutrient; metabolite; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5738 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Research on Lipid Metabolism in Animals

edited by

Bing Han

Lihong Zhao

and Zhenlong Wang

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2467 | Submission Open

Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality

(This special issue belongs to the Section Animal Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2171 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2059 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1986 | Submission Open

Keywords: natural compounds; plant metabolites; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Biosynthesis, Metabolism, and Physiological Functions of Gamma-Aminobutyric Acid (2nd Edition)

edited by

Haixing Li

and

Dandan Gao

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1822 | Submission Open

Keywords: gamma-aminobutyric acid; metabolism and metabolomics; biotechnology and bioengineering; biosynthesis; physiological function; gamma-aminobutyric-acid-producing microbes; methodology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Mass Spectrometry for Plant Metabolite Analysis: Techniques and Applications

edited by

Mila Radan

and

Prakash Babu Adhikari

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1467 | Submission Open

Keywords: mass spectrometry; plant metabolomics; biomarker discovery; metabolic networks: metabolic flux; MS data analysis; metabolic diseases

(This special issue belongs to the Section Plant Metabolism)

Research of Inborn Errors of Metabolism

edited by

Vincenza Gragnaniello

and

Maria Fuller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1107 | Submission Open

Keywords: inborn errors of metabolism; pathogenic mechanisms; bio-chemical pathway; inherited diseases; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 31 Oct 2025 | 1 articles | Viewed by 776 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Flavonoids: Novel Therapeutic Potential for Chronic Diseases

edited by Aleksandra Kozłowska and Shawn R. Campagna

submission deadline 31 Oct 2025 | 2 articles | Viewed by 763 | Submission Open

Keywords: flavonoids; chronic diseases; inflammation; diabetes; anthocyanins; cardiovascular diseases; neurodegenerative disorders; quercetin

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Oct 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Role of Nutraceuticals in Metabolic Disorders: Mechanisms and Benefits

edited by

Susmita Barman

submission deadline 31 Oct 2025 | Viewed by 372 | Submission Open

Keywords: nutraceuticals; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

Evaluation of Metabolic Changes in Mice Under Chronic Toxic Substances Exposure

edited by

Yun-Chung Hsiao

and

Kun Lu

submission deadline 31 Oct 2025 | Viewed by 220 | Submission Open

Keywords: metabolomics; environmental contaminant; persistent organic pollutant; mass spectrometry; proteomics; toxicant; toxicological assessment; chronic toxicity; xenobiotic metabolism; lipidomic; dose– response relationship; molecular toxicology

(This special issue belongs to the Section Environmental Metabolomics)

Metabolism and Reproduction in Animals

edited by