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Special Issue "“Smart” Nanomaterials for Biomedical Applications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Dr. George Pasparakis

UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK
Website | E-Mail

Special Issue Information

Dear Colleagues,

“Smart” (often referred to as “responsive”) materials are defined as materials that exhibit a sharp, and usually reversible change of their physicochemical properties (i.e., a change in shape, volume, solubility, or molecular conformation) as a result of an application of an external stimulus, such as a change in temperature or pH.

In recent years, the field of “smart” nanomaterials for biomedical applications has evolved from the basic principles of structure-to-function at the nanoscale, to intricate nanostructures and properties that find numerous uses in the biomedical field, spanning from (bio-) responsive drug delivery systems for precision medicine, targeted therapeutics, and nanomedicine, to nanosensors and actuators, and nanomaterials’ ensembles for cell therapies and tissue engineering.  

The development of the field has been mostly fuelled by the integration of bottom–up and top–down biofabrication methods with biorthogonal chemistries and controlled polymerization methods that allow for unprecedented architectural control and fidelity of the final structure at the nansoscale. The field of smart nanomaterials is dominated by polymers followed by small molecular ensembles (i.e., low molecular weight gelators, lipids, etc.), plasmonic/metallic or inorganic nanoparticles and other building components of biological origin (i.e., RNA/DNA strands, proteins, peptides, etc.).

“Smart” materials can now be designed to respond to a multitude of stimuli such as biochemical cues, and environmental factors such as temperature, humidity, pH and ionic strength, specific chemical analytes, as well as externally applied stimuli derived from magnetic or electric fields. It is expected that as we refine our fabrication/synthetic methods, these “smart” materials will start to truly emulate or even augment the delicate responsive properties which are found in Nature and, hence, it is anticipated that even more complex nanomaterials will emerge in the near future.

We invite colleagues to contribute to this Special Issue on the aforementioned concepts and keywords on the rapidly developing field of smart nanomaterials for biomedical applications.

Dr. George Pasparakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Responsive polymers
  • Hydrogels
  • Smart surfaces
  • Scaffolds for tissue engineering
  • Injectable materials for cell delivery
  • Responsive micelles for precision medicine
  • Plasmonic nanomaterials
  • Self-healing materials
  • Stimuli responsive drug delivery systems
  • Nanosensors
  • Diagnostics

Published Papers (2 papers)

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Research

Open AccessArticle Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex
Materials 2019, 12(6), 933; https://doi.org/10.3390/ma12060933
Received: 7 February 2019 / Revised: 27 February 2019 / Accepted: 7 March 2019 / Published: 21 March 2019
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Abstract
Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) [...] Read more.
Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine. Full article
(This article belongs to the Special Issue “Smart” Nanomaterials for Biomedical Applications)
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Open AccessArticle Electrochemical Corrosion Behavior and Mechanical Properties of Nanocrystalline Ti–6Al–4V Alloy Induced by Sliding Friction Treatment
Materials 2019, 12(5), 760; https://doi.org/10.3390/ma12050760
Received: 30 January 2019 / Revised: 26 February 2019 / Accepted: 27 February 2019 / Published: 5 March 2019
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Abstract
A nanograined (NG) layer with an average grain size of less than 100 nm has been successfully prepared on a Ti–6Al–4V sheet surface by sliding friction treatment (SFT). The electrochemical corrosion/passive behavior and mechanical properties of an NG Ti–6Al–4V sheet were examined in [...] Read more.
A nanograined (NG) layer with an average grain size of less than 100 nm has been successfully prepared on a Ti–6Al–4V sheet surface by sliding friction treatment (SFT). The electrochemical corrosion/passive behavior and mechanical properties of an NG Ti–6Al–4V sheet were examined in this study. A bi-layer passive film that consisted of an outer TiO2-rich layer and an inner Al2O3-rich layer was formed on either an NG or coarse-grained (CG) surface. The improved corrosion was mainly caused by the enhanced stability and thickness of the passive layer. Tensile experiments were carried out to evaluate the mechanical properties at ambient temperature. The NG Ti–6Al–4V sample exhibited the high yield strength (956 MPa) with a moderate elongation of 8%. These superior comprehensive properties demonstrated its potential as a biomedical material. Full article
(This article belongs to the Special Issue “Smart” Nanomaterials for Biomedical Applications)
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Graphical abstract

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