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Multiple Applications of Hydroxyapatite-Based Materials
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Multiple Applications of Hydroxyapatite-Based Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 10840

Special Issue Editor

Prof. Dr. Gabriela Ciobanu

E-Mail Website1 Website2
Guest Editor
Department of Organic, Biochemical and Food Engineering, Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University of Iasi, Prof. dr. doc. D. Mangeron Street no. 73, 700050 Iasi, Romania
Interests: biomaterials (hydroxyapatite, titanium and their alloys, etc.); coatings; scaffolds

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to highlighting the important progress achieved in the development of hydroxyapatite-based materials with various applications that take place at this time. Most applications of hydroxyapatite are in the medical field, in modern biotechnology processes, as in the area of dentistry, orthopedics, biomedical imaging, bioinformatics etc. On the other hand, having a versatile structure, hydroxyapatite in its pure state or combined with other materials, proves to be effective in other areas such as: making sensors, in water purification, in catalysis or ion exchange processes, etc.

We all know that currently a real challenge is the development of biomaterials with new features and properties for various applications, especially medical applications. Nowadays, the scientific research is focused on obtaining 3rd generation biomaterials, which are intelligent and adaptable materials, able to stimulate specific cellular responses to regenerate tissues and restoring their function. These biomaterials can be created by combining the properties of bioactive materials and resorbable materials, and these new materials are able to activate genes and stimulate regeneration of living tissue at the molecular level.

The hydroxyapatite-based biomaterials can be obtained in the form of nanocrystalline powders, thin films, or 3D porous matrix (scaffolds) for tissue engineering applications. These biomaterials allow the improvement of the functioning of conventional bone implants by overcoming the limitations of the individual materials and imitating the structure of the calcified tissues, while preventing the microbial infections that may occur.

Due to the possibility of designing material properties by coupling organic and inorganic components, hybrid multifunctional materials can be created for medical applications (e.g., biomaterials for tissue regeneration) or for environmental protection (e.g., composite membranes for separations).

Also, nanocrystalline hydroxyapatite has been proven to be a high efficiency, cheap, and environmentally friendly adsorbent, with a high specific surface area, high porosity, and very good ion exchange capacity, suitable for treatment processes of water contaminated with organic and heavy metal pollutants.

For this Special Issue, research on but not limited to the following biomaterials will be considered: hydroxyapatite, ceramics, metals (Ti, Mg, etc.) and their alloys, polymers, etc.


Prof. Dr. Gabriela Ciobanu
Guest Editor

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Keywords

  • Hydroxyapatite
  • Hydroxyapatite-Based Materials
  • Medical applications
  • Biomaterials
  • Coatings
  • Scaffolds
  • Industrial applications
  • Adsorption
  • Water purification
  • Catalysis

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Published Papers (4 papers)

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Research

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21 pages, 4470 KiB  
Article
Hydroxyapatite Coating on Ti-6Al-7Nb Alloy by Plasma Electrolytic Oxidation in Salt-Based Electrolyte
by Avital Schwartz, Alexey Kossenko, Michael Zinigrad, Yosef Gofer, Konstantin Borodianskiy and Alexander Sobolev
Materials 2022, 15(20), 7374; https://doi.org/10.3390/ma15207374 - 21 Oct 2022
Cited by 21 | Viewed by 2695
Abstract
Titanium alloys have good biocompatibility and good mechanical properties, making them particularly suitable for dental and orthopedic implants. Improving their osseointegration with human bones is one of the most essential tasks. This can be achieved by developing hydroxyapatite (HA) on the treating surface [...] Read more.
Titanium alloys have good biocompatibility and good mechanical properties, making them particularly suitable for dental and orthopedic implants. Improving their osseointegration with human bones is one of the most essential tasks. This can be achieved by developing hydroxyapatite (HA) on the treating surface using the plasma electrolytic oxidation (PEO) method in molten salt. In this study, a coating of titanium oxide-containing HA nanoparticles was formed on Ti-6Al-7Nb alloy by PEO in molten salt. Then, samples were subjected to hydrothermal treatment (HTT) to form HA crystals sized 0.5 to 1 μm. The effect of the current and voltage frequency for the creation of the coating on the morphology, chemical, and phase composition was studied. The anti-corrosion properties of the samples were studied using the potentiodynamic polarization test (PPT) and electrochemical impedance spectroscopy (EIS). An assessment of the morphology of the sample formed at a frequency of 100 Hz shows that the structure of this coating has a uniform submicron porosity, and its surface shows high hydrophilicity and anti-corrosion properties (4.90 × 106 Ohm·cm2). In this work, for the first time, the process of formation of a bioactive coating consisting of titanium oxides and HA was studied by the PEO method in molten salts. Full article
(This article belongs to the Special Issue Multiple Applications of Hydroxyapatite-Based Materials)
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10 pages, 1968 KiB  
Article
Snail Based Carbonated-Hydroxyapatite Material as Adsorbents for Water Iron (II)
by Bernard Owusu Asimeng, Edward Kwame Amenyaglo, David Dodoo-Arhin, Johnson Kwame Efavi, Bright Kwakye-Awuah, Elvis Kwason Tiburu, E. Johan Foster and Jan Czernuska
Materials 2022, 15(9), 3253; https://doi.org/10.3390/ma15093253 - 30 Apr 2022
Cited by 5 | Viewed by 1658
Abstract
Carbonated hydroxyapatite (CHAp) adsorbent material was prepared from Achatina achatina snail shells and phosphate-containing solution using a wet chemical deposition method. The CHAp adsorbent material was investigated to adsorb aqua Fe(II) complex; [Fe(H2O)6]2+ from simulated iron contaminated water [...] Read more.
Carbonated hydroxyapatite (CHAp) adsorbent material was prepared from Achatina achatina snail shells and phosphate-containing solution using a wet chemical deposition method. The CHAp adsorbent material was investigated to adsorb aqua Fe(II) complex; [Fe(H2O)6]2+ from simulated iron contaminated water for potential iron remediation application. The CHAp was characterized before and after adsorption using infrared (IR) and Raman spectroscopy. The IR and the Raman data revealed that the carbonate functional groups of the CHAp adsorbent material through asymmetric orientation in water bonded strongly to the aqua Fe(II) complex adsorbate. The adsorption behaviour of the adsorbate onto the CHAp adsorbent correlated well to pseudo-second-order kinetics model, non-linear Langmuir and Freundlich model at room temperature of a concentration (20–100 mg L−1) and contact time of 180 min. The Langmuir model estimated the maximum adsorption capacity to be 45.87 mg g−1 whereas Freundlich model indicated an S-type isotherm curvature which supported the spectroscopy revelation. Full article
(This article belongs to the Special Issue Multiple Applications of Hydroxyapatite-Based Materials)
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16 pages, 2237 KiB  
Article
New Horizons for Hydroxyapatite Supported by DXA Assessment—A Preliminary Study
by Jakub Litak, Cezary Grochowski, Andrzej Rysak, Marek Mazurek, Tomasz Blicharski, Piotr Kamieniak, Piotr Wolszczak, Mansur Rahnama-Hezavah and Grzegorz Litak
Materials 2022, 15(3), 942; https://doi.org/10.3390/ma15030942 - 26 Jan 2022
Cited by 1 | Viewed by 1934
Abstract
Dual Energy X-ray Absorptiometry (DXA) is a tool that allows the assessment of bone density. It was first presented by Cameron and Sorenson in 1963 and was approved by the Food and Drug Administration. Misplacing the femoral neck box, placing a trochanteric line [...] Read more.
Dual Energy X-ray Absorptiometry (DXA) is a tool that allows the assessment of bone density. It was first presented by Cameron and Sorenson in 1963 and was approved by the Food and Drug Administration. Misplacing the femoral neck box, placing a trochanteric line below the midland and improper placement of boundary lines are the most common errors made during a DXA diagnostic test made by auto analysis. Hydroxyapatite is the most important inorganic component of teeth and bone tissue. It is estimated to constitute up to 70% of human bone weight and up to 50% of its volume. Calcium phosphate comes in many forms; however, studies have shown that only tricalcium phosphate and hydroxyapatite have the characteristics that allow their use as bone-substituted materials. The purpose of this study is aimed at analyzing the results of hip densitometry and hydorxyapatite distribution in order to better assess the structure and mineral density of the femoral neck. However, a detailed analysis of the individual density curves shows some qualitative differences that may be important in assessing bone strength in the area under study. To draw more specific conclusions on the therapy applied for individual patients, we need to determine the correct orientation of the bone from the resulting density and document the trends in the density distribution change. The average results presented with the DXA method are insufficient. Full article
(This article belongs to the Special Issue Multiple Applications of Hydroxyapatite-Based Materials)
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Review

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14 pages, 332 KiB  
Review
Hydroxyapatite Use in Spine Surgery—Molecular and Clinical Aspect
by Jakub Litak, Wojciech Czyzewski, Michał Szymoniuk, Bartlomiej Pastuszak, Joanna Litak, Grzegorz Litak, Cezary Grochowski, Mansur Rahnama-Hezavah and Piotr Kamieniak
Materials 2022, 15(8), 2906; https://doi.org/10.3390/ma15082906 - 15 Apr 2022
Cited by 19 | Viewed by 3620
Abstract
Hydroxyapatite possesses desirable properties as a scaffold in tissue engineering: it is biocompatible at a site of implantation, and it is degradable to non-toxic products. Moreover, its porosity enables infiltration of cells, nutrients and waste products. The outcome of hydroxyapatite implantation highly depends [...] Read more.
Hydroxyapatite possesses desirable properties as a scaffold in tissue engineering: it is biocompatible at a site of implantation, and it is degradable to non-toxic products. Moreover, its porosity enables infiltration of cells, nutrients and waste products. The outcome of hydroxyapatite implantation highly depends on the extent of the host immune response. Authors emphasise major roles of the chemical, morphological and physical properties of the surface of biomaterial used. A number of techniques have been applied to transform the theoretical osteoconductive features of HAp into spinal fusion systems—from integration of HAp with autograft to synthetic intervertebral implants. The most popular uses of HAp in spine surgery include implants (ACDF), bone grafts in posterolateral lumbar fusion and transpedicular screws coating. In the past, autologous bone graft has been used as an intervertebral cage in ACDF. Due to the morbidity related to autograft harvesting from the iliac bone, a synthetic cage with osteoconductive material such as hydroxyapatite seems to be a good alternative. Regarding posterolateral lumbar fusion, it requires the graft to induce new bone growth and reinforce fusion between the vertebrae. Hydroxyapatite formulations have shown good results in that field. Moreover, the HAp coating has proven to be an efficient method of increasing screw fixation strength. It can decrease the risk of complications such as screw loosening after pedicle screw fixation in osteoporotic patients. The purpose of this literature review is to describe in vivo reaction to HAp implants and to summarise its current application in spine surgery. Full article
(This article belongs to the Special Issue Multiple Applications of Hydroxyapatite-Based Materials)
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