Advanced Fibrin Biomaterials

Dear Colleagues,

Fibrin is a widely used biomaterial in the clinic, particularly in surgical sealants and in regenerative medicine applications. During the past years, fibrin biomaterials have been engineered to allow tight control of their shape, polymerization and degradability. Moreover, fibrin has been extensively modified for controlled release of bioactive molecules, such as growth factors or small molecule drugs, thus serving as a delivery scaffold for therapeutics to enhance tissue regeneration. Overall, fibrin has successfully been used in a variety of tissue regeneration models, including bone, cartilage, skin, skeletal and cardiac muscles, or peripheral nerve, amongst others, which demonstrates its strong clinical potential and suggests possible expansion of its clinical use in the future. More recently, the immunomodulatory functions of fibrin have also raised interests in the field of tissue engineering; indeed, fibrin has been shown to participate in the activation of the innate immune system, which regulates subsequent tissue regeneration.

In this Special Issue, we encourage authors to submit original research articles, communications or reviews focusing either on the understanding the roles of fibrin, envisioned as a physiological biomaterial, during wound repair, or on the engineering of fibrin scaffolds and their applications to tissue regeneration.

Dr. Priscilla Briquez
Guest Editor

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