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Advances in Bioprinting Techniques and Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 3296

Special Issue Editor


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Guest Editor
1. Institute for BioMedical Printing Technology, Technical University of Darmstadt, Darmstadt, Germany
2. Center for Synthetic Biology, Technical University of Darmstadt, Darmstadt, Germany
Interests: biofabrication and 3D-bioprinting technologies; regenerative medicine, in-vitro tissue models, and organs-on-a-chip; biorobotics and smart biosynthetic systems

Special Issue Information

Dear Colleagues,

Bioprinting is an additive manufacturing process for the biofabrication of tissue-like, biological structures. Hydrogels loaded with living cells are printed using different dispensing mechanisms to reproduce the geometry and morphology of a three-dimensional virtual model.

The visionary idea of processing living cells using printing technology dates back to the beginning of the new millennium. From the initial use of modified desktop printers to highly sophisticated 3D/4D/XD platforms, the technologies have developed rapidly over the past two decades and gained attraction not only in the academic environment but also in industry and civil society.

Among the frequently cited advantages of bioprinting compared to classical tissue engineering processes are its high spatial resolution, the possibility of building multicellular and multi-material structures and the integration of blood vessels or supply channels, which are necessary for the production of comparatively thick tissue. A further advantage, which provided the original motivation for its development, is the high degree of automation and standardization bioprinting offers with the ultimate goal to upscale tissue production.

While biomedical aspects of bioprinting are frequently reported, we believe that the underlying technological advances that drive the latter merit a broader platform.

In this special edition we therefore encourage publication of original work related to recent progress in standardization, digitalization or automation of bioprinting hard- and software as well as the applied materials (bioinks).

We specifically welcome original research on:

  • Fluid- and thermodynamic modelling of bioprinting processes,
  • Gelation kinetics of bioinks,
  • Novel dispensing technology as well as biofabrication related software and algorithms.

Furthermore, we encourage research on the development and process integration of:

  • New sensor and actuator systems, such as pressure, vibration, temperature or optical sensors, in 3D-bioprinting systems,
  • Multimaterial printer heads, new fluid transport mechanisms, and advanced biofabrication tools and tool changers,
  • Modular printing platforms for printing onto self-loading substrates, microfluidic chips or into bioreactors systems.

Finally, biomedical applications that proof the automation, digitization or upscaling potential of bioprinting technology are highly appreciated.

Prof. Dr. Andreas Blaeser
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • biomaterials
  • bioinks
  • organs-on-a-chip
  • digitalization
  • automation
  • additive manufacturing
  • bioproduction
  • biofabrication
  • tissue engineering

Published Papers (1 paper)

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Research

14 pages, 4331 KiB  
Article
Improving Cell Viability and Velocity in μ-Extrusion Bioprinting with a Novel Pre-Incubator Bioprinter and a Standard FDM 3D Printing Nozzle
by Juan C. Gómez-Blanco, Victor Galván-Chacón, David Patrocinio, Manuel Matamoros, Álvaro J. Sánchez-Ortega, Alfonso C. Marcos, María Duarte-León, Federica Marinaro, José B. Pagador and Francisco M. Sánchez-Margallo
Materials 2021, 14(11), 3100; https://doi.org/10.3390/ma14113100 - 5 Jun 2021
Cited by 8 | Viewed by 2832
Abstract
Bioprinting is a promising emerging technology. It has been widely studied by the scientific community for the possibility to create transplantable artificial tissues, with minimal risk to the patient. Although the biomaterials and cells to be used are being carefully studied, there is [...] Read more.
Bioprinting is a promising emerging technology. It has been widely studied by the scientific community for the possibility to create transplantable artificial tissues, with minimal risk to the patient. Although the biomaterials and cells to be used are being carefully studied, there is still a long way to go before a bioprinter can easily and quickly produce printings without harmful effects on the cells. In this sense, we have developed a new μ-extrusion bioprinter formed by an Atom Proton 3D printer, an atmospheric enclosure and a new extrusion-head capable to increment usual printing velocity. Hence, this work has two main objectives. First, to experimentally study the accuracy and precision. Secondly, to study the influence of flow rates on cellular viability using this novel μ-extrusion bioprinter in combination with a standard FDM 3D printing nozzle. Our results show an X, Y and Z axis movement accuracy under 17 μm with a precision around 12 μm while the extruder values are under 5 and 7 μm, respectively. Additionally, the cell viability obtained from different volumetric flow tests varies from 70 to 90%. So, the proposed bioprinter and nozzle can control the atmospheric conditions and increase the volumetric flow speeding up the bioprinting process without compromising the cell viability. Full article
(This article belongs to the Special Issue Advances in Bioprinting Techniques and Materials)
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