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Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry
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Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 8434

Special Issue Editor

Dr. Bozena Tyliszczak

E-Mail Website
Guest Editor
Institute of Materials Science, Cracow University of Technology, Krakow, Poland
Interests: biomaterials; advanced materials; biodegradable polymers; biomimetic materials; nanomaterials; material science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive materials are characterized by their adaptiveness to biological environments, being designed to stimulate and/or direct appropriate cellular and tissue responses or to control interactions with microbiological species. Hydrogels are a special type of bioactive materials. They are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. This Special Issue on “Advanced Biomedical Hydrogels and Bioactive Materials in Medicinal Chemistry” of the journal Materials will focus on biomedical hydrogels and bioactive materials, their design and development, characterization, modification/functionalization, and the application of new materials. Potential topics include but are not limited to the following: biomedical hydrogels, smart hydrogels, protein and DNA hydrogels, wound dressings, bioactive polymers and gels, bioactive metals and alloys, bioactive inorganics (ceramics, glasses, and carbon-based materials), bioactive materials sourced from nature, and bioactive composites for use in human or veterinary medicine as implants, tissue-engineering scaffolds, cell/drug/gene carriers, and imaging and sensing devices.

Dr. Bozena Tyliszczak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical hydrogels
  • smart hydrogels
  • protein and DNA hydrogels
  • crosslinked hydrogels
  • biodegradable hydrogels
  • wound dressings
  • contact lenses
  • bioactive materials
  • polymers
  • biopolymers
  • metallic biomaterials
  • composites
  • nanomaterials
  • drug discovery
  • drug design
  • biomaterials
  • tissue engineering
  • regenerative medicine
  • biofabrication and bioprinting

Published Papers (5 papers)

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Research

19 pages, 7356 KiB  
Article
Physicochemical Evaluation of L-Ascorbic Acid and Aloe vera-Containing Polymer Materials Designed as Dressings for Diabetic Foot Ulcers
by Magdalena Kędzierska, Mateusz Jamroży, Sonia Kudłacik-Kramarczyk, Anna Drabczyk, Magdalena Bańkosz, Piotr Potemski and Bożena Tyliszczak
Materials 2022, 15(18), 6404; https://doi.org/10.3390/ma15186404 - 15 Sep 2022
Cited by 3 | Viewed by 1439
Abstract
Hydrogels belong to the group of polymers that are more and more often considered as innovative dressing materials. It is important to develop materials showing the most advantageous properties from the application viewpoint wherein in the case of hydrogels, the type and the [...] Read more.
Hydrogels belong to the group of polymers that are more and more often considered as innovative dressing materials. It is important to develop materials showing the most advantageous properties from the application viewpoint wherein in the case of hydrogels, the type and the amount of the crosslinking agent strongly affect their properties. In this work, PVP-based hydrogels containing Aloe vera juice and L-ascorbic acid were obtained via UV-induced polymerization. Next, their surface morphology (via both optical, digital and scanning electron microscope), sorption capacity, tensile strength, and elongation were characterized. Their structure was analyzed via FT-IR spectroscopy wherein their impact on the simulated body liquids was verified via regular pH and temperature measurements of these liquids during hydrogels’ incubation. It was demonstrated that as the amount of the crosslinker increased, the polymer structure was more wrinkled. Next, hydrogels showed relatively smooth and only slightly rough surface, which was probably due to the fact that the modifiers filled also the outer pores of the materials. Hydrogels demonstrated buffering properties in all incubation media, wherein during the incubation the release of Aloe vera juice probably took place as evidenced by the decrease in the pH of the incubation media and the disappearance of the absorption band deriving from the polysaccharides included in the composition of this additive. Next, it was proved that as the amount of the crosslinker increased, hydrogels’ crosslinking density increased and thus their swelling ratio decreased. Hydrogels obtained using a crosslinking agent with higher average molecular weight showed higher swelling ability than the materials synthesized using crosslinker with lower average molecular weight. Moreover, as the amount of the crosslinking agent increased, the tensile strength of hydrogels as well as their percentage elongation also increased. Full article
(This article belongs to the Special Issue Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry)
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20 pages, 5496 KiB  
Article
Studies on the Impact of the Photoinitiator Amount Used during the PVP-Based Hydrogels’ Synthesis on Their Physicochemical Properties
by Magdalena Kędzierska, Magdalena Bańkosz and Piotr Potemski
Materials 2022, 15(17), 6089; https://doi.org/10.3390/ma15176089 - 2 Sep 2022
Cited by 3 | Viewed by 1491
Abstract
In recent times, a great interest is directed to developing biomaterials incorporated with various therapeutical substances which may enhance them with new properties and thus increase their application potential. In this work, polyvinylpyrrolidone (PVP)-based hydrogels modified with Aloe vera juice and vitamin C [...] Read more.
In recent times, a great interest is directed to developing biomaterials incorporated with various therapeutical substances which may enhance them with new properties and thus increase their application potential. In this work, polyvinylpyrrolidone (PVP)-based hydrogels modified with Aloe vera juice and vitamin C and differing in the amount of the photoinitiator used during their synthesis were developed. Analysis of hydrogels included characterization of their chemical structure via FT-IR spectroscopy, sorption properties, wettability, surface morphology, behavior in simulated physiological liquids and mechanical properties. Finally, hydrogels’ cytotoxicity towards L929 murine fibroblasts using MTT reduction assay was additionally verified. It was demonstrated that as the amount of the photoinitiator used during the synthesis of hydrogels increased, the smoother their surface and the higher their hydrophilicity. Next, the greater the amount of the photoinitiator, the lower is the percentage elongation of the hydrogel and the greater the hardness. In turn, the swelling ability of hydrogels depended strongly on the type of the absorbed liquid—swelling ratios of samples in distilled water were 24% higher than in SBF, 18% higher than in Ringer liquid, and 32% higher than in hemoglobin wherein the amount of the photoinitiator did not affect this property. Additionally, hydrogels were stable and did not degrade in simulated physiological liquids. The only changes in pH of the incubation media were probably caused by the active substances release from hydrogels which was also confirmed via a lesser intensity of the absorption band on FT-IR spectra corresponding to the functional group occurring in compounds included in Aloe vera juice. Importantly, the viability of fibroblasts incubated with developed materials was at least 86%. Thus the hydrogels, due to their properties, seem to show application potential to be used for biomedical purposes, e.g., as innovative dressing materials. Full article
(This article belongs to the Special Issue Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry)
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15 pages, 5689 KiB  
Article
Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens
by Min-Seung Kang, Kyung-Jin Moon, Ji-Eun Lee and Young-IL Jeong
Materials 2022, 15(14), 4823; https://doi.org/10.3390/ma15144823 - 11 Jul 2022
Cited by 1 | Viewed by 1460
Abstract
The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO [...] Read more.
The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application. Full article
(This article belongs to the Special Issue Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry)
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18 pages, 4119 KiB  
Article
Iron Oxide Magnetic Nanoparticles with a Shell Made from Nanosilver—Synthesis Methodology and Characterization of Physicochemical and Biological Properties
by Magdalena Kędzierska, Anna Drabczyk, Mateusz Jamroży, Sonia Kudłacik-Kramarczyk, Magdalena Głąb, Piotr Potemski and Bożena Tyliszczak
Materials 2022, 15(12), 4050; https://doi.org/10.3390/ma15124050 - 7 Jun 2022
Cited by 1 | Viewed by 1575
Abstract
The interest in magnetic nanoparticles is constantly growing, which is due to their unique properties, of which the most useful is the possibility of directing their movement via an external magnetic field. Thus, applications may be found for them as carriers in targeted [...] Read more.
The interest in magnetic nanoparticles is constantly growing, which is due to their unique properties, of which the most useful is the possibility of directing their movement via an external magnetic field. Thus, applications may be found for them as carriers in targeted drug delivery. These nanomaterials usually form a core in a core–shell structure, and a shell may be formed via various compounds. Here, nanosilver-shelled iron oxide magnetic nanoparticles were developed. Various reaction media and various Arabic gum (stabilizer) solution concentrations were investigated to verify those that were most beneficial one in limiting their agglomeration as much as possible. The essential oil of lavender was proposed as a component of such a medium; it was used alone or in combination with distilled water as a solvent of the stabilizer. The particle size was characterized by dynamic light scattering (DLS), the chemical structure was characterized via FT-IR spectroscopy, the crystallinity was characterized by X-ray diffraction (XRD), and the surface morphology and elemental composition were verified via the SEM-EDS technique. Moreover, UV-Vis spectrophotometry was used to verify the presence of the shell made of nanosilver. Importantly, the particles’ pro-inflammatory activity and cytotoxicity towards L929 murine fibroblasts were also characterized. It was demonstrated that a 3% stabilizer solution provided a preparation of Fe3O4@Ag particles, but its stabilizing effect was not sufficient, as a suspension with micrometric particles was obtained; thus it was necessary to apply 4 h of sonication for their crushing. Next, the oil/water reaction medium was verified as beneficial in terms of nanoparticle formation. In such reaction conditions, the formation of particle agglomerates was strongly limited, and after 15 min of sonication a suspension containing only nanoparticles was obtained. The presence of a nanosilver shell was confirmed spectrophotometrically via XRD and SEM-EDS techniques. Importantly, the developed nanomaterials showed no cytotoxicity towards murine fibroblasts and no pro-inflammatory activity. Full article
(This article belongs to the Special Issue Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry)
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19 pages, 5432 KiB  
Article
The Synthesis Methodology and Characterization of Nanogold-Coated Fe3O4 Magnetic Nanoparticles
by Magdalena Kędzierska, Anna Drabczyk, Mateusz Jamroży, Sonia Kudłacik-Kramarczyk, Magdalena Głąb, Bożena Tyliszczak, Wojciech Bańkosz and Piotr Potemski
Materials 2022, 15(9), 3383; https://doi.org/10.3390/ma15093383 - 9 May 2022
Cited by 5 | Viewed by 1781
Abstract
Core-shell nanostructures are widely used in many fields, including medicine and the related areas. An example of such structures are nanogold-shelled Fe3O4 magnetic nanoparticles. Systems consisting of a magnetic core and a shell made from nanogold show unique optical and [...] Read more.
Core-shell nanostructures are widely used in many fields, including medicine and the related areas. An example of such structures are nanogold-shelled Fe3O4 magnetic nanoparticles. Systems consisting of a magnetic core and a shell made from nanogold show unique optical and magnetic properties. Thus, it is essential to develop the methodology of their preparation. Here, we report the synthesis methodology of Fe3O4@Au developed so as to limit their agglomeration and increase their stability. For this purpose, the impact of the reaction environment was verified. The properties of the particles were characterized via UV-Vis spectrophotometry, dynamic light scattering (DLS), X-ray diffraction (XRD), and Scanning Electron Microscopy-Energy Dispersive X-ray analysis (SEM-EDS technique). Moreover, biological investigations, including determining the cytotoxicity of the particles towards murine fibroblasts and the pro-inflammatory activity were also performed. It was demonstrated that the application of an oil and water reaction environment leads to the preparation of the particles with lower polydispersity, whose agglomerates’ disintegration is 24 times faster than the disintegration of nanoparticle agglomerates formed as a result of the reaction performed in a water environment. Importantly, developed Fe3O4@Au nanoparticles showed no pro-inflammatory activity regardless of their concentration and the reaction environment applied during their synthesis and the viability of cell lines incubated for 24 h with the particle suspensions was at least 92.88%. Thus, the developed synthesis methodology of the particles as well as performed investigations confirmed a great application potential of developed materials for biomedical purposes. Full article
(This article belongs to the Special Issue Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry)
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