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Development and Application of Natural Compounds

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Dear Colleagues,

Natural materials are used in such aspects of daily life as food, clothing, housing, and transportation. Due to the advancement of modern biochemical technology, many natural compounds with biologically active functions have been isolated and identified from foods, drinks, herbs, and microbes. Examples of such compounds are chitin, collagen, glucosamine, curcumin, hinokitiol, hyaluronic acid, epigallocatechin gallate (EGCG), luciferase, and melatonin. The biological activities of these natural compounds include antimicrobial, antitumor, antioxidation, and anti-inflammatory activities; the promotion of whitening or moisturizing; and the emission of fluorescence or luminescence. The combination of natural compounds and materials can increase the functionality of the materials, which can be used in textile fibers, anti-counterfeiting of boutique labels, pharmaceutical development, cosmetics, food additives, detection reagents, dental materials, cardiovascular stents, health care products, 3D printing inks, etc. For this Special Issue, we invite the submission of manuscripts focused on, but not limited to, original natural compounds, modified or nanonized natural compounds; and natural compounds combined with drug delivery, applications, and working mechanisms in medicine, dentistry, pharmacy, food science, cosmetics, tissue engineering, life science, etc.

Prof. Tzong-Ming Shieh
Guest Editor

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13 pages, 2605 KiB

Open AccessArticle

Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells

by Tamara Krajnović, Nebojša Đ. Pantelić, Katharina Wolf, Thomas Eichhorn, Danijela Maksimović-Ivanić, Sanja Mijatović, Ludger A. Wessjohann and Goran N. Kaluđerović

Materials 2022, 15(14), 5028; https://doi.org/10.3390/ma15145028 - 19 Jul 2022

Cited by 6 | Viewed by 2088

Abstract

Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC₅₀ = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC₅₀ = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC₅₀ values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated. Full article

(This article belongs to the Special Issue Development and Application of Natural Compounds)

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16 pages, 2442 KiB

Open AccessArticle

Dehydrated at Different Conditions and Powdered Leek as a Concentrate of Biologically Active Substances: Antioxidant Activity and Phenolic Compound Profile

by Beata Biernacka, Dariusz Dziki, Joanna Kozłowska, Iwona Kowalska and Agata Soluch

Materials 2021, 14(20), 6127; https://doi.org/10.3390/ma14206127 - 15 Oct 2021

Cited by 10 | Viewed by 2269

Abstract

This study aimed to analyze the antioxidant activity, phenolic acid profile, color changes, and chemical composition of dried and powdered leek (Allium porrum). Leek was divided into white shaft (WH) and green shaft (GR) and subjected to drying by different methods—convection drying, vacuum drying, and freeze-drying (FD)—at a temperature of 60 °C. A sample freeze-dried at a temperature of 20 °C was used as control. Analyses of the dried leek samples revealed that GR contained a higher amount of ash, protein, fat, fiber, phenolic acids, and flavonoids, and exhibited higher antioxidant capacity compared to WH. The dominant phenolic acid in WH was p-cumaric acid followed by synapic and protocatechuic acids. GR had a several-fold higher content of phenolic acids than WH, with ferulic acid being dominant (about 85% of the total phenolic content). It was also observed that a higher drying temperature resulted in the degradation of phenolic compounds and reduced the antioxidant properties of leek shafts. Most importantly, FD under a temperature of 60 °C caused a similar degree of degradation of biologically active compounds as air drying. An increase in drying temperature was associated with a slight decrease in the lightness of GR, whereas in the case of WH no significant change in this parameter was observed. Full article

(This article belongs to the Special Issue Development and Application of Natural Compounds)

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