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Special Issue "Antimicrobial Nanomaterials"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials".

Deadline for manuscript submissions: 15 August 2019

Special Issue Editors

Guest Editor
Prof. Luca Gavioli

i-LAMP & Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, via dei Musei 41, 25121 Brescia, Italy
Website | E-Mail
Interests: nanoscale systems; supersonic beam deposition; chemical vapor deposition; self-assembly; multielement nanoparticles; biomedical, solar energy and catalysis applications.
Guest Editor
Dr. Emanuele Cavaliere

i-LAMP & Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, via dei Musei 41, 25121 Brescia, Italy
E-Mail
Interests: nanoscale systems; supersonic beam deposition; chemical vapor deposition; self-assembly; multielement nanoparticles; biomedical, solar energy and catalysis applications.

Special Issue Information

Dear colleagues,

Nanostructured materials (NMs) represent an active area of research and a techno-economic sector with many application domains. The technological importance of NMs is due to their tunable physicochemical characteristics such as optical absorption, electrical and thermal conductivity and bactericidal functionalities. For the latter, a prominent attention is devoted to the wet synthesis of NMs and NPs and the study of their effect on cells and bacteria in solution. However the spreading of multi-drug-resistant pathogens by contamination through infected surfaces (medical implants such as dental or bone repair devices) has already had a large socio-economic impact. Infectious diseases caused by fungi, viruses, bacteria, and particularly by multidrug resistant bacteria have an estimated annual cost (direct and indirect) ranging from 6 to 60 billion US$ only in the US. This adds to the limited number of new antibiotics successfully developed in the last few decades, due to the difficulty of finding new antibacterial compounds with good pharmacological profiles and low toxicity.

Therefore a fundamental goal is finding appropriate materials able to kill bacteria such as metal based NPs, but is also to obtain functional nanostructured surfaces and/or thin films that can limit the spread of bacteria through surfaces. The topological and chemical characteristics of a surface determine the rate of microorganism adhesion and the response against bacteria, hence the ability to combine materials at the nanoscale is required.

This is increasing the challenge since the nanomaterial is required to have (1) microbicidal activity against a wide number of multi-drug-resistant Gram negative (G-) and Gram positive (G+) pathogens; (2) tunable mechanical properties, morphology and adhesion, to tailor the NP release and the film durability in different conditions; (3) cost-effective, environmental friendly production with high throughput.

In this framework, explored strategies are encompassing a wide range of wet synthesis techniques, while quite surprisingly less work is available exploring the potential of physical methods such as laser ablation, magnetron sputtering, gas phase beams. The aim of this Special Issue is therefore to report up to date results on antimicrobial coatings obtained by physical methods, encompassing not only the antimicrobial properties but also opening a window on the nanotoxicity issues of such coatings.

Prof. Luca Gavioli
Dr. Emanuele Cavaliere
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials 
  • antimicrobial properties
  • coatings 
  • functional surfaces 
  • nanostructure mechanical properties 
  • wide spectrum microbicidal effect 
  • physical synthesis of nanoparticles
  • laser ablation
  • gas phase deposition 
  • magnetron sputtering

Published Papers (1 paper)

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Review

Open AccessReview A Precautionary Approach to Guide the Use of Transition Metal-Based Nanotechnology to Prevent Orthopedic Infections
Materials 2019, 12(2), 314; https://doi.org/10.3390/ma12020314
Received: 6 December 2018 / Revised: 15 January 2019 / Accepted: 18 January 2019 / Published: 20 January 2019
Cited by 1 | PDF Full-text (627 KB) | HTML Full-text | XML Full-text
Abstract
The increase of multidrug-resistant bacteria remains a global concern. Among the proposed strategies, the use of nanoparticles (NPs) alone or associated with orthopedic implants represents a promising solution. NPs are well-known for their antimicrobial effects, induced by their size, shape, charge, concentration and [...] Read more.
The increase of multidrug-resistant bacteria remains a global concern. Among the proposed strategies, the use of nanoparticles (NPs) alone or associated with orthopedic implants represents a promising solution. NPs are well-known for their antimicrobial effects, induced by their size, shape, charge, concentration and reactive oxygen species (ROS) generation. However, this non-specific cytotoxic potential is a powerful weapon effective against almost all microorganisms, but also against eukaryotic cells, raising concerns related to their safe use. Among the analyzed transition metals, silver is the most investigated element due to its antimicrobial properties per se or as NPs; however, its toxicity raises questions about its biosafety. Even though it has milder antimicrobial and cytotoxic activity, TiO2 needs to be exposed to UV light to be activated, thus limiting its use conjugated to orthopedic devices. By contrast, gold has a good balance between antimicrobial activity as an NP and cytocompatibility because of its inability to generate ROS. Nevertheless, although the toxicity and persistence of NPs within filter organs are not well verified, nowadays, several basic research on NP development and potential uses as antimicrobial weapons is reported, overemphasizing NPs potentialities, but without any existing potential of translation in clinics. This analysis cautions readers with respect to regulation in advancing the development and use of NPs. Hopefully, future works in vivo and clinical trials will support and regulate the use of nano-coatings to guarantee safer use of this promising approach against antibiotic-resistant microorganisms. Full article
(This article belongs to the Special Issue Antimicrobial Nanomaterials)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Dr. Marta Bottagisio

2. Dr. LJ Villarreal-Gómez

3. Dr. Mahmoud Elashiry

4. Prof. Mauro POLLINI

Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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