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Functional Hydrogel for Biomedical Applications: Progress, Challenges, and Opportunities

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 633

Special Issue Editor

School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
Interests: hydrogel microsphere; hydrogel carrier; ROS sensitive hydrogel; supramolecular hydrogel; nerve tissue engineering; vascular tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As an important soft material, hydrogels consist of three-dimensional networks with a certain amount of water. Functional hydrogels are engineered materials with specific properties that are suitable for a range of applications. In recent years, significant progress has been made in the field of functional hydrogels. A large number of novel hydrogels have been developed with multiple functions, such as nano/microgels for cell growth and proliferation, hydrogel bioelectronics as biosensors and bio-actuators, thermal/photo/strain-sensitivity for smart drug release and self-healing and injectability for tissue repair and regeneration. This Special Issue focuses on the research progress, challenges and opportunities with respect to functional hydrogels from both fundamental and application aspects. The increasing interest in functional hydrogels may be due to their design and preparation, which often aims to obtain new functions or to improve the quality of existing functions. The raw materials of these hydrogels can be natural or synthetic polymers. To understand the functions of these hydrogels, a structure–property relationship can also be included.

In this Special Issue, original research articles focusing on new synthesis, innovative functionalization, theoretical models of the functional hydrogels and reviews are welcome.

Dr. Lin Ye
Guest Editor

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Keywords

  • nano/micro hydrogel sphere
  • conductive hydrogel for nerve tissue engineering
  • sensitive hydrogels such as thermal, pH and ROS responsive hydrogels
  • self-healing hydrogels
  • tough and strong hydrogels for hard tissue repair and regeneration
  • hydrogel sensors and hydrogel actuators for medical applications

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Published Papers (1 paper)

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Research

26 pages, 6855 KiB  
Article
Hydrogel Microarray for Bioanalytical Applications: Preliminary Study on Material Properties
by Weronika Kieres, Sonia Kudłacik-Kramarczyk, Joanna Marczyk, Celina Ziejewska, Anna Drabczyk, Robert P. Socha and Marcel Krzan
Materials 2025, 18(13), 3118; https://doi.org/10.3390/ma18133118 - 1 Jul 2025
Viewed by 360
Abstract
The aim of this study was to develop and characterize UV-crosslinked hydrogel matrices based on polyethylene glycol diacrylate (PEGDA), gum arabic, betaine, and sodium alginate for potential bioanalytical applications. Various physicochemical analyses were performed, including pre-polymerization emulsion stability (Multiscan), FT-IR spectroscopy, swelling behavior [...] Read more.
The aim of this study was to develop and characterize UV-crosslinked hydrogel matrices based on polyethylene glycol diacrylate (PEGDA), gum arabic, betaine, and sodium alginate for potential bioanalytical applications. Various physicochemical analyses were performed, including pre-polymerization emulsion stability (Multiscan), FT-IR spectroscopy, swelling behavior in physiological buffers, pH monitoring, contact angle measurements, and morphological assessment via SEM and optical microscopy. The results demonstrated that both alginate content and UV exposure time significantly influence the structural and functional properties of the hydrogels. The highest swelling ratio (2.32 g/g) was observed for the formulation containing 5% sodium alginate polymerized for 5 min (5SA_5), though this sample showed mechanical fragmentation during incubation. In contrast, the most balanced performance was achieved for the 10SA_15 formulation, which maintained structural integrity and exhibited a swelling ratio of 1.92 g/g after 9 days. The contact angle analysis revealed a surface hydrophilicity range from 50° to 100°, with the lowest angle (50°) recorded for 10SA_5, indicating high surface wettability. These findings confirm the suitability of such hydrogels for biomedical applications, particularly as absorbent, stable platforms for drug delivery or wound healing. Full article
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