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Special Issue "Ti-Based Biomaterials: Synthesis, Properties and Applications"
Deadline for manuscript submissions: 31 December 2019.
In the last half century, great attention has been paid to materials that can be used in the human body to prepare parts that replace failed bone structures. Of all materials, Ti-based materials are the most desirable, because they provide an optimum combination of mechanical, chemical and biological properties.
The successful application of Ti biomaterials has been confirmed mainly in dentistry, orthopedics and traumatology. The Ti provides high strength and a relatively low modulus. Ti biocompatibility is practically the highest of all metallic biomaterials, however new solutions are being sought to improve their biocompatibility and osseointegration. Thus, the chemical modification of Ti results in the formation of new alloys (for example low modulus β-type alloys) or composites (for example with hydroxyapatite), which provide new perspectives for Ti biomaterial applications.
Great attention has also been paid to the formation of nanostructures in Ti-based biomaterials, which has leads to extremely good mechanical properties and very good biocompatibility.
The surface treatment applied to Ti-based biomaterials is required to provide fast osseointegration. Oxide, nitride, DLC or hydroxyapatite surface layers are the most desired and surface technology has been extensively investigated.
Bulk and porous Ti biomaterials, which both have different properties, are used. The introduction of open spaces (voids) into the materials structure is the technological way to reduce the Young’s modulus to a level comparable to human bone.
Over the last years, great attention has been focused on additive technology (3D printing) applied to Ti biomaterials. These processes, such as SLS, SLM or related processes, which use a laser to form the designed chemical composition as well to shape the implant, have gained importance for designing implants for specific patients. The technologies are useful for the formation of bulk, porous as well as gradient biomaterials.
It is my pleasure to invite you to submit a manuscript to this Special Issue that is related to the above topic. Full papers, communications, and reviews are all welcomed.
Assoc. Prof. Jarosław Jakubowicz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Ti-based alloys and composites
- Ti-type bionanomaterials
- Ti bulk and porous biomaterials
- Ti biomaterials surface modification
- Ti additive technology
- Ti new processes
- Ti biomaterials application
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
- Biomechanical Comparison of Elastic Titanium, Nickel-Titanium and Stainless Nails in the Fixation of Diaphyseal Long Bone Fractures
Background. Elastic nail made up with nickel-titanium shape memory alloy (Nitinol) has been approved to control the bone modeling of the fractured bone in animal studies. However, the mechanical effect of the Nitinol nail in the fixation of diaphyseal long bone fracture is unclear. The objective of this study is to compare the mechanical stability of the Nitinol nail with the currently used titanium and stainless nails in the fixation of diaphyseal long bone fractures.
Methods. Cylinder sawbone with a 10-mm gap and then fixed with two C-shape elastic nails was used to exam its stability with various nail materials. Furthermore, a finite element (FE) model based on the sawbone model was created to compare the gap deformation and contact forces between the nails and the inner aspect of the canal. Three different kinds of materials, namely titanium, Nitinol and stainless, with identical shape (arc lengthπ/2 and radius 260 mm) were used in this study. Axial compression until the gap closed was conducted on the fractured sawbone without the end cap by using the material property testing system, while axial compression and bending test were considered in the FE simulation. Furthermore, the effect of end cap on the nail stability is considered in the FE simulation by a constraint equation in ANSYS Workbench.
Results. The results indicated that the titanium nail yielded a higher resistance force to against the applied load than the stainless and Nitinol nails before the cap totally closed. The FE simulation indicated that the titanium nail yielded higher stability with lesser gap deformation than the stainless and Nitinol nails in axial compression and bending without the end cap. The gap deformation in axial compression and bending was larger in the Nitinol nail than the titanium and stainless nails when the end cap was used, but the difference was minor.
Conclusion. Based on the present results, the titanium elastic nail with C-shape is the first priority in the management of diaphyseal long bone fracture when the end cap is not used. The end cap is suggested to the Nitinol and stainless nails for stopping the nail from dropping and then maintains the gap.
- The Hydrophobic Surface of NiTi Alloy Prepared by Magnetic Stirring EDM
In coronary heart disease (CHD) treatment scheme, intrusive stent is the most effective treatment and the drug eluting stent has good effect. Aiming at the problems of microporous preparation in the current surface microhole drug carrier, the paper puts forward a new process for preparing drug loaded porous on the platform surface by magnetic field assisted EDM. Nickel titanium alloy is chosen as stent material because of its good biocompatibility. The surface topography of the machined workpiece was analyzed by scanning electron microscope (SEM), hydrophobicity was measured by using video optical contact angle measuring instrument, and roughness values of different positions on the surface were measured by using the TR200 roughness instrument. This process prepares multi-scale microporous structure surface, on the other hand improves the biocompatibility of the material surface by modifying the characteristics of the surface. The effect of EDM processing factors on the formation mechanism of micropore structure and surface micro characteristics will be studied deeply in this project.
- The Process and Clinic Study of LENS Manufacturing of Customized Titanium Implants
Guangbin Zhao, Mian Qin, Yaxiong Liu
State key laboratory for manufacturing system engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
LENS manufacturing of porous structure can match the mechanical properties of the replaced bone tissue by adjusting the porosity, and realize the customized outline structure meanwhile. The influence of process parameters of LENS manufacturing on the porosity of porous structure were studied for the establishment of the model design criteria. The method of LENS manufacturing of custom hip prosthesis was studied and two cases successfully used in clinical and have good results.
- Bioactive Sphene-based Ceramic Coatings on cpTi Substrates for Dental Implants: An In Vitro Study
Titanium implant surface modifications have been widely investigated in order to favor the process of osseointegration. The present work aimed at evaluating the effect of sphene (CaTiSiO5) biocoating, on titanium substrates, on the in vitro osteogenic differentiation of Human Adipose-Derived Stem Cells (hADSCs). Sphene bioceramic coatings were prepared using preceramic polymers and nano-sized active fillers, and deposited by spray coating. SEM analysis, surface roughness measurements and X-ray diffraction analysis were performed. The chemical stability of the coatings in Tris–HCl solution was investigated. In vitro studies were performed by means of proliferation test of hADSCs seeded on coated and uncoated samples after 21 days. Methyl Thiazolyl-Tetrazolium (MTT) test and immunofluorescent staining with phalloidin confirmed the in vitro biocompatibility of both substrates. In vitro osteogenic differentiation of the cells was evaluated using Alizarin Red S staining and quantification assay and real-time PCR. When hADSCs were cultured in presence of Osteogenic Differentiation Medium, a significantly higher accumulation of calcium deposits onto the sphene-coated surfaces than on uncoated controls was detected. Osteogenic differentiation on both samples was confirmed by PCR. The proposed coating seems to be promising for orthopedic and dental implants, in terms of composition and deposition technology