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Peptide Nano-Chemistry and Nanotechnology: Materials Synthesis, Properties, and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Polymeric Materials".

Deadline for manuscript submissions: closed (10 January 2023) | Viewed by 2975

Special Issue Editor


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Special Issue Information

Dear Colleagues,

Peptides have been widely used for materials science, nanotechnology, analytical science, biomedicine, tissue engineering, and other fields due to their high biocompatibility, high bioactivity, tailored sequences/functions, flexible self-assembly ability, and biomimetic properties. Due to the high affinity of peptides to some nanomaterials (such as inorganic nanoparticles, nanotubes, graphene, and other two-dimensional materials), the formed peptide-functionalized materials are endowed with biocompatibility and bioactivity, which promote their applications in many biorelated applications, including biosensors, cancer therapy, tissue engineering, and targeted drug delivery. Additionally, peptides with special motifs can mediate the biomimetic synthesis of inorganic nanomaterials, which can be used for the fabrication of functional nanodevices for biosensing, energy storage, and environmental science applications. In addition, based on the tailoring of peptide sequences, the self-assembly ability of peptide molecules can be induced to form various superstructures, such as peptide nanospheres, nanofibrils, nanosheets, and hydrogels. The corresponding formation mechanisms of motif-designed peptides in liquid, at the air/liquid surface, and on solid substrate are crucial for guiding the design and synthesis of functional peptide nanomaterials for nanotechnological applications.

Although a lot of studies have been done in this promising research field, it is still necessary and important to conduct further investigations on the nanochemistry and nanotechnology related to peptides. The corresponding collections may be focused on these topics: (i) modification/functionalization of nanomaterials and surfaces with peptides for various applications, (ii) novel nanomaterials via the self-assembly of peptides with unique chemical, physical, and biological properties, (iii) synthesis and applications of peptide-based hybrid nanomaterials, and (iv) fabrication of peptide nanomaterial-based devices for advanced applications. Therefore, in this Special Issue, we would like to gather contributions from you on these topics (but not limited to them). Both original research and review papers are welcome.

We look forward to your great contributions to this Special Issue.

Prof. Dr. Gang Wei
Guest Editor

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Keywords

  • peptide superstructures
  • motif design of peptide
  • self-assembly behavior and mechanism
  • hybrid nanomaterials
  • functional tailoring
  • biomedical applications
  • tissue engineering
  • biosensors
  • cancer therapy
  • environmental science
  • energy storage

Published Papers (2 papers)

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Research

13 pages, 3234 KiB  
Article
Biomimetic Organic-Inorganic Hybrid Membranes for Removal of Fluoride Ions
by Yun Chen, Hao Kong, Lei Guo and Gang Wei
Materials 2022, 15(10), 3457; https://doi.org/10.3390/ma15103457 - 11 May 2022
Cited by 2 | Viewed by 1473
Abstract
Carbon nanofibers (CaNFs) exhibit promising applications in the fields of environmental science and nanotechnology, and self-assembled peptide nanofibers (PNFs) are useful for the biomimetic synthesis of organic-inorganic hybrid nanomaterials and the fabrication of functional hybrid membranes for the removal of various pollutants from [...] Read more.
Carbon nanofibers (CaNFs) exhibit promising applications in the fields of environmental science and nanotechnology, and self-assembled peptide nanofibers (PNFs) are useful for the biomimetic synthesis of organic-inorganic hybrid nanomaterials and the fabrication of functional hybrid membranes for the removal of various pollutants from water. In this work, we report the biomimetic synthesis of hybrid nanomaterials by the interweaving of CaNFs and PNFs. Using the biomimetic mineralization properties of PNFs, ZrO2 nanoparticles were synthesized along the nanofiber surface, and then functional nanohybrid porous membranes were prepared by the vacuum filtration technology. For the fabrication of membranes, the amount of PNFs and ZrO2 precursors in the hybrid membrane were optimized. The designed organic-inorganic hybrid membranes exhibited high removal performance for fluorine ion (F) from water, and the removal efficiency of the fabricated membranes towards F ion-containing aqueous solution with a concentration of 50–100 mg/L reached more than 80%. In addition, the nanofiltration membranes revealed good adsorption capacity for F ions. It is expected that the strategies shown in this study will be beneficial for the design, biomimetic synthesis, and fabrication of nanoporous membranes for economic, rapid, and efficient water purification. Full article
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11 pages, 10446 KiB  
Article
Tailoring Peptide Self-Assembly and Formation of 2D Nanoribbons on Mica and HOPG Surface
by Hao Kong, Bin Liu, Guozheng Yang, Yun Chen and Gang Wei
Materials 2022, 15(1), 310; https://doi.org/10.3390/ma15010310 - 02 Jan 2022
Cited by 5 | Viewed by 1859
Abstract
Studying the interactions between biomolecules and material interfaces play a crucial role in the designing and synthesizing of functional bionanomaterials with tailored structure and function. Previously, a lot of studies were performed on the self-assembly of peptides in solution through internal and external [...] Read more.
Studying the interactions between biomolecules and material interfaces play a crucial role in the designing and synthesizing of functional bionanomaterials with tailored structure and function. Previously, a lot of studies were performed on the self-assembly of peptides in solution through internal and external stimulations, which mediated the creation of peptide nanostructures from zero-dimension to three-dimension. In this study, we demonstrate the self-assembly behavior of the GNNQQNY peptide on the surface of mica and highly oriented pyrolytic graphite through tailoring the self-assembly conditions. Various factors, such as the type of dissolvent, peptide concentration, pH value, and evaporation period on the formation of peptide nanofibers and nanoribbons with single- and bi-directional arrays are investigated. It is found that the creation of peptide nanoribbons on both mica and HOPG can be achieved effectively through adjusting and optimizing the experimental parameters. Based on the obtained results, the self-assembly and formation mechanisms of peptide nanoribbons on both material interfaces are discussed. It is expected that the findings obtained in this study will inspire the design of motif-specific peptides with high binding affinity towards materials and mediate the green synthesis of peptide-based bionanomaterials with unique function and application potential. Full article
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