Special Issue "Nanomaterials for Drug Delivery"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 15 October 2020.

Special Issue Editors

Dr. Valentina Grumezescu

Guest Editor
Lasers Department, National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania
Interests: nanobiomaterials; nanocarriers for drug delivery, pharmaceutical nanotechnology; bioactive materials; drug delivery; anti-biofilm surfaces; therapeutic applications; targeted delivery of nanoparticles; nanomodified surfaces; thin films; natural products
Special Issues and Collections in MDPI journals
Dr. Oana Gherasim

Guest Editor
1. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, RO-011061 Bucharest, Romania
2. Lasers Department, National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania
Interests: materials science and engineering; (micro-/nano-)biomaterials; biomedical devices; laser processing of (bio)materials; bioactive coatings; applied chemistry and chemical engineering; therapeutic (micro-/nano-)biomaterials; biomedicine and life sciences
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The interdisciplinary and multidisciplinary knowledge from modern nanobiotechnologies has contributed to the impressive development of genuine nanosized and nanostructured biomaterials and biocompatible platforms. These nanomaterials have improved biocompatibility and mostly utilize environmentally-friendly technologies for the development of novel materials for biomedical use.

Recently developed nanomaterials exhibit attractive physicochemical properties, possess versatile and tunable functionality, and have proved to be suitable and performance-enhanced candidates as bioactive nanocoatings for improved implantable and exploratory devices, nanoplatforms for specific and selective detection and imaging, nanostructures for tissue restauration and regeneration, and as nanosystems for controlled, targeted, and circumstantially triggered drug delivery.

Depending on the preparation method, the therapeutic substance (naturally derived or synthetic drug) is either physically entrapped in or covalently bound to the matrix of the pharmaceutical nanosystem. The resulting compounds may have the structure of capsules (nanoparticles or nanostructured microspheres), amphiphilic core/shell structures (micelles or liposomes), or hyperbranched macromolecules.

Within this Special Issue “Nanomaterials for Drug Delivery”, we invite members of academic and scientific communities to contribute their latest findings on nanosized and nanostructured biomaterials intended for new pharmaceutically-active formulations. We are especially looking for relevant studies and reports on organic macromolecules (natural and synthetic polymers, membranes and films, scaffolds and gels), carbonaceous materials (single and multiwalled carbon nanotubes, fullerenes, graphene and graphene oxide), oxides (nanoparticles, micro- and mesoporous materials), metal nanostructures (noble metal nanoparticles, quantum dots), and composite materials.

Dr. Eng. Valentina Grumezescu
Dr. Eng. Oana Gherasim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surface engineering and functionalization
  • bioactive and therapeutic nanomaterials
  • natural and synthetic biomaterials in drug delivery
  • inorganic and organic biomaterials in drug delivery
  • composite and hybrid drug delivery formulations
  • pharmacologically-active formulations
  • pharmacotherapy and pharmacognosy
  • targeted and triggered drug delivery

Published Papers (1 paper)

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Research

Open AccessArticle
Development of Sustained-Release Ophthalmic Formulation Based on Tranilast Solid Nanoparticles
Materials 2020, 13(7), 1675; https://doi.org/10.3390/ma13071675 (registering DOI) - 03 Apr 2020
Abstract
Eye drops containing Tranilast (TL), N-(3,4-dimethoxycinnamoyl) anthramilic acid, are used as an anti-allergic conjunctivitis drug in the ophthalmic field. Traditional eye drops are very patient compliant, although the bioavailability (BA) of most eye drops is low since eye drops cannot be [...] Read more.
Eye drops containing Tranilast (TL), N-(3,4-dimethoxycinnamoyl) anthramilic acid, are used as an anti-allergic conjunctivitis drug in the ophthalmic field. Traditional eye drops are very patient compliant, although the bioavailability (BA) of most eye drops is low since eye drops cannot be instilled beyond the capacity of the conjunctival sac due to its limited volume. Thus, traditional eye drops have low BA and a short duration of the drug on the ocular surface, so solutions to these problems are highly anticipated. In this study, we designed a sustained-release drug-delivery system (DDS) for TL nanoparticles. TL nanoparticles were prepared by bead mill treatment, and the gel formulations containing TL nanoparticles (TL-NPs-Gel, particle size 50 nm–100 nm) were provided by carboxypolymethylene. The crystal structure of TL with and without bead mill treatment is the same, but the TL solubility in formulations containing nanoparticles was 5.3-fold higher compared with gel formulations containing TL microparticles (TL-MPs-Gel). The photo and thermal stabilities of TL-NPs-Gel are also higher than those of dissolved TL. Moreover, when TL-NPs-Gel is applied to the upper eyelid skin (outside), the TL is released as nanoparticles, and delivered to the lacrimal fluid through the meibomian glands. In addition, the TL release profile for TL-NPs-Gel was sustained over 180 min after the treatment. These findings can be used to develop a sustained-release DDS in the ophthalmic field. Full article
(This article belongs to the Special Issue Nanomaterials for Drug Delivery)
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