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Novel Engineered Nanomaterials for Advanced Biological Applications
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Novel Engineered Nanomaterials for Advanced Biological Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (20 January 2022) | Viewed by 7724

Special Issue Editor

Dr. Helena Oliveira

E-Mail Website
Guest Editor
Department of Biology, CESAM—Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: cytotoxicity; genotoxicity; nanoparticles for biological applications; nanotoxicity; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials are currently being used for several applications in the industrial, pharmaceutical, and biomedical fields. The widespread use of nanomaterials is due to their enhanced properties compared to their bulk counterparts allowing novel applications. In recent decades, a considerable number of engineered nanomaterials were have been with the purpose of a biomedical application mainly focused on diagnosis and disease therapy. Hence, organic, inorganic, and hybrid nanomaterials have been developed and used, for instance, in targeted drug delivery, hyperthermia, photodynamic therapy, bioimaging, and biosensors.

In this Special Issue, we invite you to submit research articles, review papers, and short communications focused on general topics related to the development of novel nanomaterials for advanced biological applications, including (i) synthesis and design of functional nanomaterials for advanced biological applications; and (ii) biomedical applications such as bioimaging, photodynamic therapy, hyperthermia therapy, and drug delivery. Interdisciplinary approaches are also much welcomed. We anticipate that this Special Issue will present the recent advancements on nanoparticle developments for biological applications.

Dr. Helena Oliveira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functionalization of nanomaterials
  • Hyperthermia
  • Magnetic hyperthermia
  • Drug delivery
  • Biosensors
  • Bioimaging
  • Synergistic therapy
  • Photodynamic therapy
  • NIR-responsive nanomaterials
  • Upconverting nanoparticles
  • Metallic nanoparticles
  • Organic nanoparticles
  • Hybrid nanomaterials
  • Multifunctional nanoparticles

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Published Papers (2 papers)

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Research

16 pages, 20702 KiB  
Article
3D Printing of Macro Porous Sol-Gel Derived Bioactive Glass Scaffolds and Assessment of Biological Response
by Ricardo Bento, Anuraag Gaddam, Párástu Oskoei, Helena Oliveira and José M. F. Ferreira
Materials 2021, 14(20), 5946; https://doi.org/10.3390/ma14205946 - 10 Oct 2021
Cited by 11 | Viewed by 2622
Abstract
3D printing emerged as a potential game-changer in the field of biomedical engineering. Robocasting in particular has shown excellent capability to produce custom-sized porous scaffolds from pastes with suitable viscoelastic properties. The materials and respective processing methods developed so far still need further [...] Read more.
3D printing emerged as a potential game-changer in the field of biomedical engineering. Robocasting in particular has shown excellent capability to produce custom-sized porous scaffolds from pastes with suitable viscoelastic properties. The materials and respective processing methods developed so far still need further improvements in order to obtain completely satisfactory scaffolds capable of providing both the biological and mechanical properties required for successful and comprehensive bone tissue regeneration. This work reports on the sol-gel synthesis of an alkali-free bioactive glass and on its characterization and processing ability towards the fabrication of porous scaffolds by robocasting. A two-fold increase in milling efficiency was achieved by suitably adjusting the milling procedures. The heat treatment temperature exerted a profound effect on the surface area of mesoporous powders. Robocasting inks containing 35 vol.% solids were prepared, and their flow properties were characterized by rheological tests. A script capable of preparing customizable CAD scaffold geometries was developed. The printing process was adjusted to increase the technique’s resolution. The mechanical properties of the scaffolds were assessed through compressive strength tests. The biomineralization ability and the biological performance were assessed by immersing the samples in simulated body fluid (SBF) and through MTT assays, respectively. The overall results demonstrated that scaffolds with macro porous features suitable for bone ingrowth (pore sizes of ~340 μm after sintering, and a porosity fraction of ~70%) in non-load-bearing applications could be successfully fabricated by 3D printing from the bioactive glass inks. Moreover, the scaffolds exhibited good biomineralization activity and good biocompatibility with human keratinocytes, suggesting they are safe and thus suited for the intended biomedical applications. Full article
(This article belongs to the Special Issue Novel Engineered Nanomaterials for Advanced Biological Applications)
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18 pages, 3935 KiB  
Article
Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy
by Diogo Marinheiro, Bárbara J. M. L. Ferreira, Párástu Oskoei, Helena Oliveira and Ana L. Daniel-da-Silva
Materials 2021, 14(6), 1382; https://doi.org/10.3390/ma14061382 - 12 Mar 2021
Cited by 37 | Viewed by 4252
Abstract
Chemotherapy has limited success in the treatment of malignant melanoma due to fast development of drug resistance and the low bioavailability of chemotherapeutic drugs. Resveratrol (RES) is a natural polyphenol with recognized preventive and therapeutic anti-cancer properties. However, poor RES solubility hampers its [...] Read more.
Chemotherapy has limited success in the treatment of malignant melanoma due to fast development of drug resistance and the low bioavailability of chemotherapeutic drugs. Resveratrol (RES) is a natural polyphenol with recognized preventive and therapeutic anti-cancer properties. However, poor RES solubility hampers its bioactivity, thus creating a demand for suitable drug delivery systems to improve it. This work aimed to assess the potential of RES-loaded mesoporous silica nanoparticles (MSNs) for human melanoma treatment. RES was efficiently loaded (efficiency > 93%) onto spheroidal (size~60 nm) MSNs. The encapsulation promoted the amorphization of RES and enhanced the release in vitro compared to non-encapsulated RES. The RES release was pH-dependent and markedly faster at pH 5.2 (acid environment in some tumorous tissues) than at pH 7.4 in both encapsulated and bulk forms. The RES release from loaded MSNs was gradual with time, without a burst effect, and well-described by the Weibull model. In vitro cytotoxicity studies on human A375 and MNT-1 melanoma cellular cultures showed a decrease in the cell viability with increasing concentration of RES-loaded MSNs, indicating the potent action of the released RES in both cell lines. The amelanotic cell line A375 was more sensitive to RES concentration than the melanotic MNT-1 cells. Full article
(This article belongs to the Special Issue Novel Engineered Nanomaterials for Advanced Biological Applications)
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