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Bioceramics and Related Hybrid Materials for Tissue Reconstruction
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Bioceramics and Related Hybrid Materials for Tissue Reconstruction

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 10482

Special Issue Editor

Prof. Dr. Toshiki Miyazaki

E-Mail Website
Guest Editor
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan
Interests: inorganic biomaterials; organic-inorganic hybrids; biomineralization

Special Issue Information

Dear Colleagues,

Bioceramics have been clinically used for repairing hard tissues such as bone, teeth, and joints because they have a high biocompatibility to bond to bone. Hybridization, such as bioceramic coating on metal implants for artificial joints to impart osteoconduction and the improvement of mechanical properties by bioceramics-polymer hybrids is also extensively promoted. In the future, we expect that bioceramics and hybrid materials with a highly hierarchical structure through biomimetic processes that mimics the process of tissue formation in the living body, and novel biological functions including as antibacterial properties and sensing/imaging properties will be developed. In this Special Issue, we are looking for papers on the latest achievements in bioceramics and related hybrid materials.

Prof. Toshiki Miyazaki
Guest Editor

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Keywords

  • bioceramics
  • hybrid materials
  • hard tissue repair
  • biomimetic process
  • sensing
  • imaging
  • antibacterial properties
  • implant materials
  • tissue engineering
  • dental application

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Published Papers (4 papers)

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Research

13 pages, 2855 KiB  
Article
Surface Modification of Carbon Fiber-Polyetheretherketone Composite to Impart Bioactivity by Using Apatite Nuclei
by Yuya Yamane, Takeshi Yabutsuka, Yusuke Takaoka, Chihiro Ishizaki, Shigeomi Takai and Shunsuke Fujibayashi
Materials 2021, 14(21), 6691; https://doi.org/10.3390/ma14216691 - 6 Nov 2021
Cited by 6 | Viewed by 2231
Abstract
The authors aimed to impart the apatite-forming ability to 50 wt% carbon fiber-polyetheretherketone composite (50C-PEEK), which has more suitable mechanical properties as artificial bone materials than pure PEEK. First, the 50C-PEEK was treated with sulfuric acid in a short time to form pores [...] Read more.
The authors aimed to impart the apatite-forming ability to 50 wt% carbon fiber-polyetheretherketone composite (50C-PEEK), which has more suitable mechanical properties as artificial bone materials than pure PEEK. First, the 50C-PEEK was treated with sulfuric acid in a short time to form pores on the surface. Second, the surface of the 50C-PEEK was treated with oxygen plasma to improve the hydrophilicity. Finally, fine particles of calcium phosphate, which the authors refer to as “apatite nuclei”, were precipitated on the surface of the 50C-PEEK by soaking in an aqueous solution containing multiple inorganic ions such as phosphate and calcium (modified-SBF) at pH 8.20, 25 °C. The 50C-PEEK without the modified-SBF treatment did not show the formation of apatitic phase even after immersion in simulated body fluid (SBF) for 7 days. The 50C-PEEK treated with the modified-SBF showed the formation of apatitic phase on the entire surface within 1 day in the SBF. The apatite nuclei-precipitated 50C-PEEK will be expected as a new artificial bone material with high bioactivity that is obtained without complicated fabrication processes. Full article
(This article belongs to the Special Issue Bioceramics and Related Hybrid Materials for Tissue Reconstruction)
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8 pages, 12232 KiB  
Article
Understanding the Steric Structures of Dicarboxylate Ions Incorporated in Octacalcium Phosphate Crystals
by Taishi Yokoi and Masakazu Kawashita
Materials 2021, 14(11), 2703; https://doi.org/10.3390/ma14112703 - 21 May 2021
Cited by 8 | Viewed by 2504
Abstract
Octacalcium phosphate (OCP) can incorporate various dicarboxylate ions in the interlayer spaces of its layered structure. Although not proven, these incorporated ions are believed to have a linear structure. In this study, the steric structures of twelve different dicarboxylate ions incorporated into OCP [...] Read more.
Octacalcium phosphate (OCP) can incorporate various dicarboxylate ions in the interlayer spaces of its layered structure. Although not proven, these incorporated ions are believed to have a linear structure. In this study, the steric structures of twelve different dicarboxylate ions incorporated into OCP were investigated by comparing the experimentally determined interlayer distance of the OCP with the distance estimated using the molecular sizes of dicarboxylic acids calculated by considering their steric structures. The results revealed that the incorporated succinate, glutarate, adipate, pimelate, suberate, and aspartate ions possessed linear structures, whereas the incorporated azelate, sebacate, methylsuccinate, and malate ions exhibited bent structures. Further, the incorporated mercaptosuccinate ions featured linear, bent, other types of structures. Moreover, the steric structure of the incorporated malonate ion significantly differed from those of other dicarboxylate ions. The computational approach employed in this study is expected to deepen our understanding of the steric structures of dicarboxylate ions incorporated in the OCP interlayer spaces. Full article
(This article belongs to the Special Issue Bioceramics and Related Hybrid Materials for Tissue Reconstruction)
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Graphical abstract

11 pages, 3164 KiB  
Article
Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles
by Seiya Suzuki, Sungho Lee, Tatsuya Miyajima, Katsuya Kato, Ayae Sugawara-Narutaki, Makoto Sakurai and Fukue Nagata
Materials 2021, 14(8), 1959; https://doi.org/10.3390/ma14081959 - 14 Apr 2021
Cited by 9 | Viewed by 2468
Abstract
Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be [...] Read more.
Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The particles were 40–80 nm in diameter with a PLA core and a HAp shell. The particle size increased with an increase in the vitamin K1 loading. The drug-loading capacity (LC) value of the particles, an indicator of their drug-loading ability, was approximately 250%, which is higher than the previously reported values. The amount of vitamin K1 released from the particles increased as the pH of the soaking solution decreased because the HAp shell easily dissolved under the acidic conditions. The PLA/HAp particles prepared in this work were found to be promising candidates for drug delivery carriers because of their excellent drug-loading ability and pH sensitivity. Full article
(This article belongs to the Special Issue Bioceramics and Related Hybrid Materials for Tissue Reconstruction)
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13 pages, 2834 KiB  
Article
Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses
by Sungho Lee, Fukue Nagata, Katsuya Kato, Takayoshi Nakano and Toshihiro Kasuga
Materials 2021, 14(7), 1736; https://doi.org/10.3390/ma14071736 - 1 Apr 2021
Cited by 9 | Viewed by 2460
Abstract
Calcium phosphate glasses have a high potential for use as biomaterials because their composition is similar to that of the mineral phase of bone. Phosphate glasses can dissolve completely in aqueous solution and can contain various elements owing to their acidity. Thus, the [...] Read more.
Calcium phosphate glasses have a high potential for use as biomaterials because their composition is similar to that of the mineral phase of bone. Phosphate glasses can dissolve completely in aqueous solution and can contain various elements owing to their acidity. Thus, the glass can be a candidate for therapeutic ion carriers. Recently, we focused on the effect of strontium ions for bone formation, which exhibited dual effects of stimulating bone formation and inhibiting bone resorption. However, large amounts of strontium ions may induce a cytotoxic effect, and there is a need to control their releasing amount. This work reports fundamental data for designing quaternary CaO-SrO-P2O5-TiO2 glasses with pyro- and meta-phosphate compositions to control strontium ion-releasing behavior. The glasses were prepared by substituting CaO by SrO using the melt-quenching method. The SrO/CaO mixed composition exhibited a mixed cation effect on the glassification degree and ion-releasing behavior, which showed non-linear properties with mixed cation compositions of the glasses. Sr2+ ions have smaller field strength than Ca2+ ions, and the glass network structure may be weakened by the substitution of CaO by SrO. However, glassification degree and chemical durability of pyro- and meta-phosphate glasses increased with substituted all CaO by SrO. This is because titanium groups in the glasses are closely related to their glass network structure by SrO substitution. The P-O-Ti bonds in pyrophosphate glass series and TiO4 tetrahedra in metaphosphate glass series increased with substitution by SrO. The titanium groups in the glasses were crosslink and/or coordinate phosphate groups to improve glassification degree and chemical durability. Sr2+ ion releasing amount of pyrophosphate glasses with >83% SrO substitution was larger than 0.1 mM at day seven, an amount that reported enhanced bone formation by stimulation of osteogenic markers. Full article
(This article belongs to the Special Issue Bioceramics and Related Hybrid Materials for Tissue Reconstruction)
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