Special Issue "Bioceramics: Materials, Properties and Applications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced and Functional Ceramics".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Dr. Frédéric Velard
E-Mail Website
Guest Editor
Université de Reims Champagne-Ardenne, EA 4691 BIOS, REIMS, France
Interests: bone; ceramics; inflammation; in vitro; in vivo

Special Issue Information

Dear Colleagues,

The field of bioceramics is constantly growing. The main applications of bioceramics address the topics of drug delivery and tissue regeneration, especially for hard tissues such as teeth and bones. Thanks to new engineering approaches, the reconstruction of human tissues is becoming a reality. Yet, many fundamental problems remain to be solved for hard tissues such as bone. One of them is the requirement of adequate scaffold able to support, promote, and stimulate tissue ingrowth. New synthesis routes and functionalization, as well as original manufacturing processes, may help to overcome these limitations. Many avenues have to be explored to develop new bioceramics with properties intended to favor biological tissue regeneration. More new materials may lead to original applications for bioceramics. Therefore, this Special Issue of Materials will collect original, high-quality research papers covering the most recent advances and comprehensive reviews addressing state-of-the-art topics in the field of bioceramics materials, their properties, and their application systems for current and futuristic biomedical applications.

Dr. Frédéric Velard
Guest Editor

Manuscript Submission Information

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Keywords

  • Bioceramics
  • Synthesis
  • Doping elements
  • Manufacturing
  • Characterization
  • Biological activity
  • 3D scaffolds
  • Biocompatibility
  • Inflammation
  • Infection
  • Regenerative properties

Published Papers (3 papers)

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Research

Open AccessArticle
Copper-Doped Biphasic Calcium Phosphate Powders: Dopant Release, Cytotoxicity and Antibacterial Properties
Materials 2021, 14(9), 2393; https://doi.org/10.3390/ma14092393 - 04 May 2021
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Abstract
Cytotoxicity and antibacterial properties associated with the dopant release of Cu-doped Biphasic Calcium Phosphate (BCP) powders, mainly composed of hydroxyapatite mixed with β-tricalcium phosphate powders, were investigated. Twelve BCP ceramics were synthesized at three different sintering temperatures (600 °C, 900 °C and 1200 [...] Read more.
Cytotoxicity and antibacterial properties associated with the dopant release of Cu-doped Biphasic Calcium Phosphate (BCP) powders, mainly composed of hydroxyapatite mixed with β-tricalcium phosphate powders, were investigated. Twelve BCP ceramics were synthesized at three different sintering temperatures (600 °C, 900 °C and 1200 °C) and four copper doping rates (x = 0.0, 0.05, 0.10 and 0.20, corresponding to the stoichiometric amount of copper in Ca10Cux(PO4)6(OH)2-2xO2x). Cytotoxicity assessments of Cu-doped BCP powders, using MTT assay with human-Mesenchymal Stem Cells (h-MSCs), indicated no cytotoxicity and the release of less than 12 ppm of copper into the biological medium. The antibacterial activity of the powders was determined against both Gram-positive (methicillin-sensitive (MS) and methicillin resistant (MR) Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The Cu-doped biomaterials exhibited a strong antibacterial activity against MSSA, MRSA and E. coli, releasing approximatively 2.5 ppm after 24 h, whereas 10 ppm were required to induce an antibacterial effect against P. aeruginosa. This study also demonstrated that the culture medium used during experiments can directly impact the antibacterial effect observed; only 4 ppm of Cu2+ were effective for killing all the bacteria in a 1:500 diluted TS medium, whereas 20 ppm were necessary to achieve the same result in a rich, non-diluted standard marrow cell culture medium. Full article
(This article belongs to the Special Issue Bioceramics: Materials, Properties and Applications)
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Open AccessArticle
Early Short-Term Postoperative Mechanical Failures of Current Ceramic-on-Ceramic Bearing Total Hip Arthroplasties
Materials 2020, 13(23), 5318; https://doi.org/10.3390/ma13235318 - 24 Nov 2020
Viewed by 519
Abstract
Although ceramic-on-ceramic (CoC) bearings have been shown to produce the smallest amount of wear volume in vitro as well as in vivo studies when used for total hip arthroplasties (THA), concerns about the failure of these bearing surfaces persist due to early failures [...] Read more.
Although ceramic-on-ceramic (CoC) bearings have been shown to produce the smallest amount of wear volume in vitro as well as in vivo studies when used for total hip arthroplasties (THA), concerns about the failure of these bearing surfaces persist due to early failures observed after short postoperative time. In this study, an exhaustive analysis of the early failure occurred on the new generation of ceramic bearings, consisting of a composite alumina matrix-based material reinforced with yttria-stabilized tetragonal zirconia (Y-TZP) particles, chromium dioxide, and strontium crystals, was performed. For this study, 118 CoC bearings from 117 patients were revised. This article describes a group of mechanical failure CoC-bearing BIOLOX THA hip prosthesis patients without trauma history. The retrieved samples were observed under scanning electron microscopy (SEM), composition was analyzed with energy dispersive X-ray spectroscopy (EDX), and damaged surfaces were analyzed by grazing-incidence X-ray diffraction (GI-XRD) and white light interferometry. In the short term, CoC articulations provided similar mechanical behavior and functional outcome to those in XLPE cases. However, 5% more early mechanical failures cases were observed for the ceramic components. Although the fracture rate of third generation CoC couples is low, the present study shows the need to further improve the third generation of CoC-bearing couples for THA. Despite the improved wear compared to other materials, stress concentrators are sources of initial crack propagation, such as those found in the bore-trunnion areas. Moreover, in view of the evidence observed in this study, the chipping observed was due to the presence of monoclinic phase of the Y-TZP instead of tetragonal, which presents better mechanical properties. The results showed that total safety after receiving a THA is still a goal to be pursued. Full article
(This article belongs to the Special Issue Bioceramics: Materials, Properties and Applications)
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Open AccessArticle
Fabrication, Mechanical Properties and In-Vitro Behavior of Akermanite Bioceramic
Materials 2020, 13(21), 4887; https://doi.org/10.3390/ma13214887 - 30 Oct 2020
Viewed by 403
Abstract
Pure nanocrystalline akermanite (Ca2MgSi2O7) powder was synthesized by mechanical activation with subsequent annealing of talc, calcium carbonate, and silicate powders as the initial materials. Powder samples were characterized by X-ray diffractometry (XRD), scanning electron microscopy (SEM), thermogravimetric [...] Read more.
Pure nanocrystalline akermanite (Ca2MgSi2O7) powder was synthesized by mechanical activation with subsequent annealing of talc, calcium carbonate, and silicate powders as the initial materials. Powder samples were characterized by X-ray diffractometry (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) techniques. The results showed that pure nanocrystalline akermanite with a crystalline size of 35 nm was synthesized after ball milling the initial powders for 20 h with subsequent annealing at 900 °C for 1 h. Mechanical properties of bulk akermanite samples were studied as well. The results showed that the produced akermanite tablets sintered at 1200 °C for 5 h had a Young’s modulus of 3800 MPa, an ultimate compressive strength of 24.7 MPa, and a density of 2.489 g/cm3. The in-vitro behavior of the produced akermanite was evaluated by soaking the samples in an SBF solution. The results showed that the produced akermanite had the apatite formation ability on its surface and can be a good candidate for bone tissue engineering applications. Full article
(This article belongs to the Special Issue Bioceramics: Materials, Properties and Applications)
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