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Materials
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New Challenges in Cell-Biomaterial Interface
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New Challenges in Cell-Biomaterial Interface

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 4362

Special Issue Editors

Prof. Dr. Anca Dinischiotu

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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
Interests: biocompatibility; tissue engineering; nanotoxicology; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andreea Iren Șerban

E-Mail Website
Guest Editor
Department of Preclinical Sciences, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 105 Blvd., Splaiul Independentei, 050097 Bucharest, Romania
Interests: biocompatibility; tissue engineering; genomic and transcriptomic analysis; inflammation

Special Issue Information

Dear Colleagues,

Through tissue engineering, which regenerates tissues damaged due to trauma, diseases and aging can be addressed. The interaction between cells and material is critical in this approach. The presence of a biomaterial of inorganic or organic origin in a biological environment affects the cellular functions. Surface topography, roughness, pattern dimensions, as well as molecular structure, surface charge and hydrophilicity are important for cell–biomaterial interactions. Cells’ adhesion on biomaterials is critical for cell communication, migration, proliferation and differentiation and is dependent on the dynamic formation of an extracellular matrix (ECM) which is produced recognized and remodeled by cells. In the framework of this crosstalk, adhesion proteins (collagen, fibronectin, laminin and vitronectin) are ligands for integrin receptors, which are involved in focal contacts and cytoskeleton remodeling.  In this context, macrophages are activated in vivo by several intracellular signaling pathways, generating pro-inflammatory molecules in a topology-surface-dependent manner. Oxidative stress could occur in all of these processes.

This Special Issue focuses on tissue engineering and aims to gather information regarding biomaterials and their medical application to provide a comprehensive view regarding the mechanisms involved in cell–biomaterial interaction.

Prof. Dr. Anca Dinischiotu
Prof. Dr. Andreea Iren Șerban
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Material characterization
  • Tissue engineering
  • Biocompatibility
  • Oxidative stress
  • Signaling pathways
  • Inflammation

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Published Papers (2 papers)

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Research

29 pages, 3934 KiB  
Article
Interplay of Oxidative Stress, Inflammation, and Autophagy in RAW 264.7 Murine Macrophage Cell Line Challenged with Si/SiO2 Quantum Dots
by Loredana Stanca, Ovidiu Ionut Geicu, Andreea Iren Serban and Anca Dinischiotu
Materials 2023, 16(14), 5083; https://doi.org/10.3390/ma16145083 - 19 Jul 2023
Cited by 4 | Viewed by 2214
Abstract
Quantum dots (QDs) with photostable fluorescence are recommended for imaging applications; however, their effect on living cells is incompletely understood. We aimed to elucidate the RAW 264.7 murine macrophage cell line’s response to the Si/SiO2 QDs challenge. Cells were exposed to 5 [...] Read more.
Quantum dots (QDs) with photostable fluorescence are recommended for imaging applications; however, their effect on living cells is incompletely understood. We aimed to elucidate the RAW 264.7 murine macrophage cell line’s response to the Si/SiO2 QDs challenge. Cells were exposed to 5 and 15 μg/mL Si/SiO2 QDs for 6 h, 12 h, and 24 h. Cell metabolic activity and viability were assessed by MTT, live/dead, and dye-exclusion assays. Oxidative stress and membrane integrity were assessed by anion superoxide, malondialdehyde, and lactate dehydrogenase activity evaluations. Antioxidative enzyme activities were analyzed by kinetic spectrophotometric methods. Cytokines were analyzed with an antibody-based magnetic bead assay, PGE2 was assessed by ELISA, and Nrf-2, Bcl-2, Beclin 1, and the HSPs were analyzed by western blot. Autophagy levels were highlighted by fluorescence microscopy. The average IC50 dose for 6, 12, and 24 h was 16.1 ± 0.7 μg/mL. Although glutathione S-transferase and catalase were still upregulated after 24 h, superoxide dismutase was inhibited, which together allowed the gradual increase of malondialdehyde, anion superoxide, nitric oxide, and the loss of membrane integrity. G-CSF, IL-6, TNF-α, MIP-1β, MCP-1, Nrf-2, PGE2, and RANTES levels, as well as autophagy processes, were increased at all time intervals, as opposed to caspase 1 activity, COX-2, HSP60, and HSP70, which were only upregulated at the 6-h exposure interval. These results underscore that Si/SiO2 QDs possess significant immunotoxic effects on the RAW 264.7 macrophage cell line and stress the importance of developing effective strategies to mitigate their adverse impact. Full article
(This article belongs to the Special Issue New Challenges in Cell-Biomaterial Interface)
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17 pages, 5460 KiB  
Article
In-Vitro Study of Indium (III) Sulfate-Containing Medium on the Viability and Adhesion Behaviors of Human Dermal Fibroblast on Engineered Surfaces
by Ali Eskandari, Evelyn K. F. Yim, D. Moira Glerum and Ting Y. Tsui
Materials 2023, 16(10), 3814; https://doi.org/10.3390/ma16103814 - 18 May 2023
Viewed by 1596
Abstract
Tissues and organs consist of cells organized in specified patterns that support their function, as exemplified by tissues such as skin, muscle, and cornea. It is, therefore, important to understand how external cues, such as engineered surfaces or chemical contaminants, can influence the [...] Read more.
Tissues and organs consist of cells organized in specified patterns that support their function, as exemplified by tissues such as skin, muscle, and cornea. It is, therefore, important to understand how external cues, such as engineered surfaces or chemical contaminants, can influence the organization and morphology of cells. In this work, we studied the impact of indium sulfate on human dermal fibroblast (GM5565) viability, production of reactive oxygen species (ROS), morphology, and alignment behavior on tantalum/silicon oxide parallel line/trench surface structures. The viability of cells was measured using the alamarBlue™ Cell Viability Reagent probe, while the ROS levels in cells were quantified using cell-permeant 2′,7′-dichlorodihydrofluorescein diacetate. Cell morphology and orientation on the engineered surfaces were characterized using fluorescence confocal and scanning electron microscopy. When cells were cultured in media containing indium (III) sulfate, the average cell viability decreased by as much as ~32% and the concentration of cellular ROS increased. Cell geometry became more circular and compact in the presence of indium sulfate. Even though actin microfilaments continue to preferentially adhere to tantalum-coated trenches in the presence of indium sulfate, the cells are less able to orient along the line axes of the chips. Interestingly, the indium sulfate-induced changes in cell alignment behavior are pattern dependent—a larger proportion of adherent cells on structures with line/trench widths in the range of 1 μm and 10 μm lose the ability to orient themselves, compared to those grown on structures with line widths smaller than 0.5 μm. Our results show that indium sulfate impacts the response of human fibroblasts to the surface structure to which they adhere and underscores the importance of evaluating cell behaviors on textured surfaces, especially in the presence of potential chemical contaminants. Full article
(This article belongs to the Special Issue New Challenges in Cell-Biomaterial Interface)
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