ECM-Mimetic Biomaterials for Tissue Engineering
A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 12
Special Issue Editors
Interests: biomaterials; tissue engineering; ECM; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Significant progress has been made in tissue engineering in recent years, among which biomimetic nanofibers mimicking the extracellular matrix (ECM) have emerged as a pivotal research topic, advancing the field of regenerative medicine. The ECM is a dynamic and hierarchically organized microenvironment that regulates cellular behavior and tissue homeostasis through integrated biochemical and biophysical signals. However, faithfully replicating its structural and functional complexity remains a major challenge. The development of nanofibers that mimic key features of the ECM represents a highly promising research focus. In particular, creating adaptive nanofibrous scaffolds that can effectively interact with cells and dynamically emulate the native ECM microenvironment remains an ongoing challenge.
This Special Issue is dedicated to highlighting cutting-edge advances in the design, fabrication, and functionalization of ECM-mimetic nanofibers that better replicate native tissue microenvironments, with the goal of improving regenerative outcomes. Topics of interest include, but are not limited to, the following research areas:
- Multi-material and hybrid systems that mimic the compositional diversity of the ECM;
- Advanced fabrication techniques enabling control over fiber alignment, porosity, and hierarchical organization;
- Functionalization approaches incorporating bioactive motifs to guide cell adhesion, differentiation, and tissue-specific remodeling;
- Smart scaffolds responsive to physiological stimuli for spatiotemporal delivery of therapeutic agents;
- Other related topics.
We look forward to receiving your contributions to this Special Issue.
Dr. Yazhou Chen
Dr. Linawati Sutrisno
Guest Editors
Manuscript Submission Information
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Keywords
- extracellular matrix
- nanofibers
- tissue engineering
- dynamic
- microenvironment
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