Natural Product Genomics and Metabolomics of Marine Microorganisms
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 685
Special Issue Editors
Interests: marine natural products; marine microorganisms; metabolomics; mass spectrometry; drug discovery
Interests: marine natural products chemistry; secondary metabolomics; NMR- and MS-based metabolomics; marine biotechnology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Marine microorganisms are an abundant and sustainable source of novel natural products with complex structural features and promising biological activities with unique mechanisms of action, thus, their growing presence in the research spotlight for more than a decade now. Current developments in computing technology have made it possible for relatively low cost and high-quality genome packages, leading to an exponential increase of publicly available microbial genomes. In combination with the advancement of bioinformatics tools, researchers can unravel the unique biosynthetic machinery of marine microbes to elicit and prompt the discovery of new metabolites.
Analytical techniques such as MS and NMR have been rapidly evolving and contributing to high-throughput coupled systems to aid the isolation and chemical characterization of natural products. Metabolomics is gaining attention within the field of natural products, which is evident by the increasing number of publications in recent years. Metabolomics has become an efficient tool for dereplication studies employed for isolation and optimising the yield of targeted biologically active metabolites in microbial fermentation cultures.
Both genomics and metabolomics have enabled the definition of interesting natural products as targets for further bioprospecting. However, it remains a challenge to integrate genomics and metabolomics data for accelerating microbial natural product discovery to improve yields and optimize the biological efficacy of targeted metabolites. With the surging occurrence of multidrug resistance and the emergence of new diseases, the search for new potential drugs has never been more relevant to confront in the “omics era”. This Special Issue is inviting studies on multi-omics approaches based on metabolomics and genomics for marine microbial natural products for drug discovery.
Dr. Sylvia Soldatou
Dr. RuAngelie Edrada-Ebel
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- dereplication
- genome mining
- multi-omics
- chemical profiling
- untargeted metabolomics
- biosynthetic gene cluster
- secondary metabolites
- specialised metabolites
- structure elucidation
- marine biotechnology
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