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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Male Urogenital Disorders: Management and Therapeutic Targets

edited by Mahadevan Rajasekaran

submission deadline 28 Feb 2027 | Viewed by 197 | Submission Open

Keywords: male urogenital disorders; erectile dysfunction; bladder outlet obstruction; premature ejaculation; male infertility; therapeutic targets; management strategies; translational research; regenerative therapy

(This special issue belongs to the Section Medical Research)

Advances in Oocyte and Embryo Cryopreservation

edited by Krzysztof Papis

submission deadline 28 Feb 2027 | Viewed by 130 | Submission Open

Keywords: vitrification; slow freezing; oocyte; embryo; human; bovine; horse

(This special issue belongs to the Section Reproductive and Developmental Biology)

Methylglyoxal and Glycative Stress in Health, Aging and Disease

edited by

Laura Cianfruglia

and

Salvatore Vaiasicca

submission deadline 28 Feb 2027 | Viewed by 110 | Submission Open

Keywords: methylglyoxal; glycative stress; dicarbonyl stress; glyoxalase pathway; advanced glycation end-products (AGEs); inflammaging; cellular senescence; aging and age-related diseases; biomarkers

(This special issue belongs to the Section Physiology and Pathology)

Radiobiology, Radiomics, AI, and Nanomedicine in Precision Oncology

edited by Viviana Benfante and

Pierpaolo Alongi

submission deadline 28 Feb 2027 | Viewed by 110 | Submission Open

Keywords: cancer radioimmunotherapy and radiobiology; radiomics and multimodal imaging; artificial intelligence; nanomedicine; molecular imaging; theranostics; radiopharmaceuticals; targeted radionuclide therapy (TRT); tumor organoids and 3D spheroid models (NAMs); precision oncology and the effects of combination therapies

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

The Plant-Virus Interactions

edited by

Hernán Garcia-Ruiz

submission deadline 28 Feb 2027 | Viewed by 105 | Submission Open

Keywords: plant–virus interactions; molecular mechanisms; antiviral strategies; CRISPR/Cas; RNA interference; viral diagnostics; crop resistance; pathogenesis; sustainable crop protection; biotechnological control

(This special issue belongs to the Section Plant Science)

Antimicrobial Resistance and Infections: Epidemiology, Mechanisms and Treatment

edited by Natalia G. Vallianou

submission deadline 28 Feb 2027 | Viewed by 101 | Submission Open

Keywords: antimicrobial resistance; antimicrobial surveillance; antimicrobial agents

(This special issue belongs to the Section Epidemiology)

Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases—2nd Edition

edited by

Doina Adina Todea

and

Damiana-Maria Vulturar

submission deadline 28 Feb 2027 | Viewed by 98 | Submission Open

Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; artificial intelligence in pulmonology; digital health; lung cancer; pulmonary hypertension; respiratory infections; personalized medicine; pulmonary function; interventional pulmonology; lung transplantation

(This special issue belongs to the Section Medical Research)

Oxidative Stress, Neurodegeneration, and Neuropharmacology: Mechanisms and Protective Strategies

edited by Maja Jazvinšćak Jembrek

submission deadline 28 Feb 2027 | Viewed by 87 | Submission Open

Keywords: neuroprotection; signalling pathways; nutraceuticals; mitochondrial function; neuroinflammation

(This special issue belongs to the Section Medical Research)

Novel Insights into Stress and Nutritional Regulation in Animals

edited by Hao-Yang Sun,

Qi-Ye Wang

, Zhan-Wei Teng and Xiao Liu

submission deadline 1 Mar 2027 | Viewed by 381 | Submission Open

Keywords: stress; nutrition; resilience; gut–X axis; microbiome; precision nutrition; multi-omics

(This special issue belongs to the Section Animal Science)

Treatment Strategies for Acute Respiratory Distress Syndrome and Acute Hypoxemic Respiratory Failure

edited by

Prashant Nasa

submission deadline 3 Mar 2027 | Viewed by 98 | Submission Open

Keywords: acute hypoxemic respiratory failure; mechanical ventilation; respiratory failure; ARDS; subphenotyping; prone ventilation

(This special issue belongs to the Section Medical Research)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 10 Mar 2027 | 1 articles | Viewed by 2953 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Ultrasound and Anatomical Studies

edited by

Maribel Miguel-Pérez

, Ingrid Moller and

Albert Pérez-Bellmunt

submission deadline 15 Mar 2027 | 1 articles | Viewed by 1142 | Submission Open

Keywords: ultrasound techniques; musculoskeletal system; human anatomy; medicine specialties; clinical students; ultrasound teaching

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1351 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

(This special issue belongs to the Section Medical Research)

The Nexus of Redox Signaling, Metabolism, and Mitochondrial Function in Cardiovascular Diseases

edited by

Manivannan Yegambaram

and

Adel Nefzi

submission deadline 20 Mar 2027 | Viewed by 156 | Submission Open

Keywords: cardiovascular diseases; mitochondrial metabolism; redox signaling; oxidative stress; HIF-1α regulation; mitochondrial dynamics

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases, 2nd Edition

edited by

Cristina Marginean

submission deadline 20 Mar 2027 | Viewed by 123 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Ecological and Evolutionary Consequences of Insecticide Resistance in Agricultural and Stored-Product Insect Pests

edited by Md Munir Mostafiz

submission deadline 21 Mar 2027 | Viewed by 57 | Submission Open

Keywords: insecticide resistance; fitness costs; evolutionary ecology; pest management; resistance mechanisms; life-history traits; behavioural resistance; stored-product pests; agricultural pests; integrated pest management

(This special issue belongs to the Section Biodiversity, Ecology and Evolution)

Pathogenesis and Novel Treatment for Kidney Diseases

edited by

Nomy Levin-Iaina

submission deadline 24 Mar 2027 | 4 articles | Viewed by 2906 | Submission Open

Keywords: molecular mechanisms of kidney disease; pathophysiology of renal injury; inflammation and fibrosis in kidney disease; novel therapeutic targets; precision medicine in nephrology; translational approaches in renal disease

(This special issue belongs to the Section Medical Research)

Feature Papers in Medical Research: 4th Edition

edited by

Christian Lehmann

submission deadline 26 Mar 2027 | 9 articles | Viewed by 11813 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Novel Insights for Spinal Pain Management: From Physical Therapies to Ultrasound-Guided Procedures

edited by

Ke-Vin Chang

and

Vincenzo Ricci

submission deadline 26 Mar 2027 | Viewed by 459 | Submission Open

Keywords: spine; pain; physical therapies; rehabilitation; ultrasound; procedures

(This special issue belongs to the Section Medical Research)

Advances in Endovascular Therapies and Acute Stroke Management—2nd Edition

edited by

Anna Podlasek

submission deadline 26 Mar 2027 | Viewed by 134 | Submission Open

Keywords: mechanical thrombectomy; endovascular reperfusion; stroke intervention technologies; acute ischemic stroke treatment; stroke imaging biomarkers

(This special issue belongs to the Section Medical Research)

Treatment and Prognosis of Thoracic Diseases

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Mar 2027 | 1 articles | Viewed by 2484 | Submission Open

Keywords: thoracic malignancies; lung cancer management ; targeted therapy ; immunotherapy ; molecular diagnostics ; multidisciplinary care ; personalized treatment

(This special issue belongs to the Section Medical Research)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 31 Mar 2027 | 3 articles | Viewed by 14100 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Intensive Care Medicine: Current Concepts and Future Perspectives

edited by Shinichi Watanabe

submission deadline 31 Mar 2027 | 4 articles | Viewed by 6635 | Submission Open

Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration

(This special issue belongs to the Section Medical Research)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy—2nd Edition

edited by

Kallirhoe Kalinderi

submission deadline 31 Mar 2027 | 2 articles | Viewed by 3758 | Submission Open

(This special issue belongs to the Section Medical Research)

Drug Safety

edited by

Andrej Belančić

and Slobodan Jankovic

submission deadline 31 Mar 2027 | 6 articles | Viewed by 2356 | Submission Open

Keywords: adverse drug reactions; drug safety; pharmacovigilance; drug interactions; signal detection; personalized medicine

(This special issue belongs to the Section Pharmaceutical Science)

Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology

edited by Sashi S. Kommu

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2112 | Submission Open

Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET, mpMRI); targeted therapies (PARP, FGFR, DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence

(This special issue belongs to the Section Medical Research)

Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition

edited by Paolo Scanagatta

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1953 | Submission Open

Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances

(This special issue belongs to the Section Medical Research)

Advanced Research in Plant Physiology, Metabolism and Signal Transduction

edited by Xiaomin Wang

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1609 | Submission Open

Keywords: plant development; plant–environment interaction; plant–microbe interactions; signaling transduction; stress adaptation

(This special issue belongs to the Section Plant Science)

New Screening Methods for Diagnosis of Cardiovascular Diseases

edited by

Raluca-Ioana Stefan-van Staden

, Ruxandra Maria Ilie-Mihai and Damaris Cristina Gheorghe

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1244 | Submission Open

Keywords: cardiovascular diseases; biomarkers; screening methods; sensor; spectroscopic methods; chromatographic methods

(This special issue belongs to the Section Medical Research)

Precision Oncology Through Diagnostic Imaging and Theranostics

edited by

Wensi Tao

, Luyuan Li and Yu-Ping Yang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1043 | Submission Open

Keywords: cancer imaging; molecular imaging; theranostics; nanomedicine; imaging biomarkers; precision oncology

(This special issue belongs to the Section Medical Research)

Neural Mechanisms of Brain–Computer Interfaces

edited by

Miguel Pais-Vieira

submission deadline 31 Mar 2027 | 1 articles | Viewed by 642 | Submission Open

Keywords: brain–machine interfaces; neurophysiology; somatosensory cortex; motor cortex

(This special issue belongs to the Section Physiology and Pathology)

Pathogenesis, Biomarkers, and Targeted Therapeutic Strategies Across Multiple Human Malignancies

edited by Chia-Hsin Liu

submission deadline 31 Mar 2027 | 2 articles | Viewed by 461 | Submission Open

Keywords: cancer pathogenesis; biomarkers; targeted therapy; artificial intelligence; machine learning; deep learning; precision oncology; open scientific data

(This special issue belongs to the Section Physiology and Pathology)

Translational Advances in Postoperative Pain: From Mechanisms to Clinical Application

edited by

Sau Ching Stanley Wong

and Boya Liao

submission deadline 31 Mar 2027 | Viewed by 290 | Submission Open

Keywords: postoperative pain; perioperative medicine; chronic postsurgical pain; multimodal analgesia; neu-romodulation; inflammation and pain; opioid sparing strategies; translational pain research; chronic postsurgical pain; persistent opioid use

(This special issue belongs to the Section Medical Research)

Evolution and Functional Regulation of Plant Genes, and Pharmacological Potential of Plant Bioactive Compounds

edited by

Xiaoming Song

Rong Zhou

and

Weike Duan

submission deadline 31 Mar 2027 | 1 articles | Viewed by 281 | Submission Open

Keywords: plant gene evolution; functional gene; gene family; nutritional value; functional genomics; stress resistance; pharmacological evaluation; medicinal plants; horticultural plants

(This special issue belongs to the Section Plant Science)

Neuromodulation Therapies for Chronic Pain: Mechanisms, Prediction, and Strategies

edited by Chiyoung Lee

submission deadline 31 Mar 2027 | Viewed by 216 | Submission Open

Keywords: brain neuromodulation; chronic pain; multimodal approach; neuroimaging; heterogeneous treatment effects; mechanisms of action; artificial intelligence; machine learning

(This special issue belongs to the Section Medical Research)

Regenerative Rehabilitation and Tissue Reconstruction: Biological Mechanisms Driving Functional Recovery

edited by Stefano Bonomi and

Augusto Fusco

submission deadline 31 Mar 2027 | Viewed by 143 | Submission Open

Keywords: regenerative rehabilitation; neuroplasticity; mechanotransduction; tissue reconstruction; stem cells; extracellular matrix; neuromodulation; stroke; brain injury; translational medicine

(This special issue belongs to the Section Medical Research)

Prostate Cancer: From Molecular Insights to Clinical Applications

edited by Marília Figueira,

Claudio Maia

and

Mariana Feijó

submission deadline 31 Mar 2027 | Viewed by 99 | Submission Open

Keywords: prostate cancer; precision medicine; biomarkers; genomics; molecular diagnostics; tumor microenvironment; therapeutic resistance; targeted therapies; liquid biopsy; translational oncology

(This special issue belongs to the Section Physiology and Pathology)

Advances in Infectious Disease Pathogenesis and Protective Immunity

edited by

Qiangde Duan

, Weiping Zhang and Shengmei Pang

submission deadline 31 Mar 2027 | Viewed by 98 | Submission Open

Keywords: pathogenesis; animal infectious diseases; host–pathogen interactions; protective immunity; bacterial pathogens; viral pathogens; vaccines; adjuvants; immune responses

(This special issue belongs to the Section Animal Science)

Advances in Livestock Nutrition and Intestinal Microecology

edited by

Yinghui Li

and Lingyuan Yang

submission deadline 31 Mar 2027 | Viewed by 88 | Submission Open

Keywords: livestock nutrition; intestinal microecology; gut microbiota; intestinal health; host–microbe interaction; feed additives; omics technology; gut barrier function; sustainable livestock production

(This special issue belongs to the Section Animal Science)

Immune Deficiency and Fungal Infections: Immune Mechanisms, Pathology and Microbial Characteristics

edited by Vasileios Oikonomou and

Teresa Zelante

submission deadline 31 Mar 2027 | Viewed by 87 | Submission Open

Keywords: immune deficiency; fungal infections; antifungal immunity; host defense; host–pathogen interactions; immunopathology; fungal virulence; immune evasion; antifungal resistance; fungal pathogenesis

(This special issue belongs to the Section Medical Research)

New Insights into Marine Bacterial Diversity, Biodegradation and Algicidal Control

edited by

Yang Jia

and

Lei Ren

submission deadline 31 Mar 2027 | Viewed by 75 | Submission Open

Keywords: marine bacterial diversity; biodegradation; organic pollutants; polysaccharide degradation; algicidal bacteria; harmful algal blooms; marine microbiology; bioremediation

(This special issue belongs to the Section Microbiology)

Testing and Treatment for Inborn Errors of Immunity: The Sustained Quest to Shorten the Diagnostic Odyssey and Advance Curative Therapies

edited by

Aaruni Khanolkar

submission deadline 9 Apr 2027 | Viewed by 145 | Submission Open

Keywords: inborn errors of immunity; immunologic flow cytometry; molecular diagnostics; stem cell transplantation; thymic transplantation; gene therapy; clinical outcomes

(This special issue belongs to the Section Medical Research)

Plant-Based Diets and Cardiometabolic Health

edited by Miguel Lopez-Moreno

submission deadline 15 Apr 2027 | Viewed by 101 | Submission Open

Keywords: plant-based diets; cardiometabolic health; cardiovascular disease; type 2 diabetes; plant protein; inflammation; gut microbiota; precision nutrition; sustainable diets

(This special issue belongs to the Section Medical Research)

Nutritional Regulation of Animal Mammary Lactation

edited by Chaochao Luo, Tongjun Guo and Xuejun Gao

submission deadline 16 Apr 2027 | Viewed by 125 | Submission Open

Keywords: animal mammary lactation; lactation regulation; nutrient signaling; mammary epithelial cells; milk component synthesis; multi-omics; rumen microbial metabolites; bioactive compounds; mammary metabolic homeostasis; mammary gland physiology

(This special issue belongs to the Section Animal Science)

Cardiometabolic and Structural Heart Disease: From Molecular Mechanisms to Multimodal Imaging and Integrated Treatment

edited by

Panayotis Vlachakis

submission deadline 18 Apr 2027 | Viewed by 47 | Submission Open

Keywords: cardiometabolic disease; structural heart disease; multimodal cardiac imaging; heart failure with preserved ejection fraction; transcatheter intervention

(This special issue belongs to the Section Medical Research)

Immune Regulation in Tissue Repair and Regeneration

edited by

Joanna Wessely-Szponder

, Michal Latalski and Tomasz Szponder

submission deadline 18 Apr 2027 | Viewed by 47 | Submission Open

Keywords: immune response to trauma; regenerative medicine; biomaterials; oxidative stress; blood-derived products

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Structure and Function of Microbial Communities—2nd Edition

edited by

Qing Hu

and

Xuliang Zhuang

submission deadline 20 Apr 2027 | Viewed by 55 | Submission Open

Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability

(This special issue belongs to the Section Microbiology)

Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans: 2nd Edition

edited by

Akos Koller

submission deadline 26 Apr 2027 | Viewed by 75 | Submission Open

Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; aging; neurovascular coupling; transcranial Doppler measurement; EEG; lifestyle

(This special issue belongs to the Section Physiology and Pathology)