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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health

edited by

Thomas Tsiampalis

and Matina Kouvari

submission deadline 25 May 2026 | 1 articles | Viewed by 9172 | Submission Open

Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors

(This special issue belongs to the Section Epidemiology)

Animal Nutritional Physiology: Effects of Feed Additives on Livestock Products

edited by

Anna Arczewska-Włosek

and Katarzyna Poltowicz

submission deadline 25 May 2026 | Viewed by 1051 | Submission Open

Keywords: feed additives; animal health; animal performance; animal-derived products; animal nutritional physiology

(This special issue belongs to the Section Physiology and Pathology)

Molecular Signatures and Biomarkers in Human Diseases

edited by Manuela Montanaro and Alfonso Baldi

submission deadline 25 May 2026 | Viewed by 60 | Submission Open

Keywords: biomarkers; therapeutic biomarkers; circulating biomarkers; molecular signatures; molecular imaging; precision medicine; targeted therapies; technological innovations

(This special issue belongs to the Section Medical Research)

Coronary Artery Disease: Pathophysiological Mechanisms, Imaging Modalities and Therapeutic Implications

edited by

Michele Russo

and Filippo Luca Gurgoglione

submission deadline 26 May 2026 | 5 articles | Viewed by 19665 | Submission Open

Keywords: coronary artery disease; coronary atherosclerosis; atherosclerotic plaque progression; coronary imaging; cardiovascular risk factors and coronary atherosclerosis-associated diseases

(This special issue belongs to the Section Medical Research)

Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment

edited by

Eliza Elena Cintezǎ

and

Ştefana Moisǎ

submission deadline 26 May 2026 | 3 articles | Viewed by 4577 | Submission Open

Keywords: congenital heart disease; cardiovascular imaging; minimally invasive interventions; fetal cardiology; transcatheter therapies; artificial intelligence in cardiology; 3D echocardiography; cardiac MRI; personalized medicine; genetic heart disorders; heart failure in children; robotic-assisted surgery; cardiovascular biomarkers; electrophysiology in pediatrics; innovative surgical techniques; early diagnosis of heart disease; emerging therapies in cardiology

(This special issue belongs to the Section Medical Research)

Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases

edited by

John Ong

submission deadline 26 May 2026 | 1 articles | Viewed by 1990 | Submission Open

Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease

(This special issue belongs to the Section Medical Research)

Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice: 2nd Edition

edited by Ralitsa Robeva

submission deadline 27 May 2026 | Viewed by 127 | Submission Open

Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)

(This special issue belongs to the Section Physiology and Pathology)

Advanced Research in Exercise Medicine

edited by

Ai-Lun Yang

submission deadline 28 May 2026 | 3 articles | Viewed by 14728 | Submission Open

Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease

edited by

Marcin Kosmalski

and Monika Różycka-Kosmalska

submission deadline 28 May 2026 | 7 articles | Viewed by 12448 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension

(This special issue belongs to the Section Medical Research)

Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases

edited by

Doina-Adina Todea

Anca-Diana Maierean

and

Damiana-Maria Vulturar

submission deadline 28 May 2026 | 3 articles | Viewed by 2603 | Submission Open

Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery

(This special issue belongs to the Section Medical Research)

Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy

edited by

Dimitrios A. Flevas

and

Ioannis Gkiatas

submission deadline 28 May 2026 | 2 articles | Viewed by 2554 | Submission Open

Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery

(This special issue belongs to the Section Medical Research)

Microglia, Behavior, and Sex Differences: Neuroimmune Mechanisms in Development and Disease

edited by Irene García Domínguez

submission deadline 28 May 2026 | Viewed by 88 | Submission Open

Keywords: microglia; neuroinflammation; sex differences; neurodevelopment; behavior; neuroimmune mechanisms; brain disorders

(This special issue belongs to the Section Physiology and Pathology)

The 15th Anniversary of Life—Alternatives to RNA World

edited by

Doron Lancet

and Amit Kahana

submission deadline 29 May 2026 | Viewed by 488 | Submission Open

Keywords: supramolecular; lipid; assembly; protocell; compositional; information; spontaneous; catalytic; network; reproduction; species; Darwinian; evolution; origin; life

(This special issue belongs to the Section Origin of Life)

Musculoskeletal Disorders: Integrative Insights into Pathophysiology, Therapeutic Strategies, and Rehabilitation

edited by

Carmelo Pirri

submission deadline 30 May 2026 | Viewed by 173 | Submission Open

Keywords: musculoskeletal disorders; high-resolution imaging; biomarkers; ultrasound-guided therapy; regenerative medicine; personalized rehabilitation; wearable sensors; translational musculoskeletal research

(This special issue belongs to the Section Medical Research)

The Role of Natural Products in Disease Treatment

edited by

Bruce Chi-Kang Tsai

submission deadline 30 May 2026 | Viewed by 128 | Submission Open

Keywords: natural products; bioactive compounds; functional foods and nutraceuticals; disease prevention and treatment

(This special issue belongs to the Section Plant Science)

Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition

edited by

Valentin Nicolae Varlas

submission deadline 30 May 2026 | Viewed by 108 | Submission Open

Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies

(This special issue belongs to the Section Medical Research)

New Mechanisms and Insights into Insect Silk Gland Biology and Silk Production

edited by Wenliang Qian

submission deadline 30 May 2026 | Viewed by 104 | Submission Open

Keywords: silk gland morphogenesis; liquid-to-solid phase transition; biomimetic microfluidic spinning; silk gland multi-omics; silk protein evolutionary adaptations; CRISPR

(This special issue belongs to the Section Animal Science)

Advances in Skin-Related Disease: Pathogenesis and Novel Therapeutic Strategies

edited by

Elisabetta Palazzo

and

Marika Quadri

submission deadline 31 May 2026 | 4 articles | Viewed by 13683 | Submission Open

Keywords: skin pathologies; skin cancer; eczema; acne; psoriasis; skin microbiome

(This special issue belongs to the Section Physiology and Pathology)

Prognosis and Management of Dry Eye Disease

edited by

Hugo Pena-Verdeal

Alena Furdova

and

Jacobo Garcia-Queiruga

submission deadline 31 May 2026 | 3 articles | Viewed by 8751 | Submission Open

Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands

(This special issue belongs to the Section Medical Research)

New Insights into Pediatric Rheumatic and Autoimmune Diseases

edited by

Lampros Fotis

submission deadline 31 May 2026 | 1 articles | Viewed by 3615 | Submission Open

Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis

(This special issue belongs to the Section Medical Research)

Current and Future Perspectives of Takotsubo Syndrome

edited by Luca Arcari

submission deadline 31 May 2026 | 2 articles | Viewed by 2747 | Submission Open

Keywords: takotsubo syndrome; heart failure; microvascular dysfunction; inflammation; myocardial edema; heart– brain axis; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Lymphomas

edited by Magdalena Witkowska

submission deadline 31 May 2026 | 2 articles | Viewed by 2361 | Submission Open

Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies

(This special issue belongs to the Section Medical Research)

Innovative Cardiovascular Interventions: From Imaging to Precision Therapies

edited by

Anastasios Apostolos

submission deadline 31 May 2026 | 1 articles | Viewed by 1304 | Submission Open

Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies

(This special issue belongs to the Section Physiology and Pathology)

Advances in Wildlife Behavior and Biodiversity

edited by

Katarzyna Tajchman

and

Pawel Janiszewski

submission deadline 31 May 2026 | 1 articles | Viewed by 1180 | Submission Open

Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence

(This special issue belongs to the Section Diversity and Ecology)

Harmful Algal Bloom Risk: Mechanisms, Prediction, Impacts and Mitigation

edited by Lixia Shang

submission deadline 31 May 2026 | 1 articles | Viewed by 809 | Submission Open

Keywords: harmful algal blooms; marine risk; bloom mechanisms; prediction models; mitigation strategies; ecosystem impact

(This special issue belongs to the Section Diversity and Ecology)

Physiological, Pathological, and Clinical Effects of Exercise Training and Physical Activity

edited by Chia-Huei Lin

submission deadline 31 May 2026 | 1 articles | Viewed by 348 | Submission Open

Keywords: exercise training; physical activity; individualized exercise prescription; physiological adaptation; chronic disease prevention; cardiovascular fitness; musculoskeletal health; neuroplasticity; metabolic syndrome; inflammation and immunity; stroke recovery; physical activity monitoring; mental health and exercise; cognitive function; aging and physical activity; sedentary behavior; physical function outcomes; patient-reported outcomes; clinical trial

(This special issue belongs to the Section Physiology and Pathology)

Hybrid Molecules in Drug Discovery: From Antidiabetic Agents to Anticancer Therapeutics

edited by Jatinder Singh and Shreyosree Chatterjee

submission deadline 31 May 2026 | Viewed by 250 | Submission Open

Keywords: hybrid molecules; drug discovery; antidiabetic; oncology; structure— activity relationships

(This special issue belongs to the Section Pharmaceutical Science)

Biofluid Mechanics and Medical Diagnostic Simulations

edited by

Violeta Carvalho

and

Adrian Neagu

submission deadline 31 May 2026 | Viewed by 187 | Submission Open

Keywords: biofluid mechanics; computational modeling; medical diagnostics; fluid-structure interaction; patient-specific modeling

(This special issue belongs to the Section Medical Research)

New Screening Methods for Diagnosis of Cardiovascular Diseases

edited by

Raluca-Ioana Stefan-van Staden

, Ruxandra Maria Ilie-Mihai and Damaris Cristina Gheorghe

submission deadline 31 May 2026 | Viewed by 176 | Submission Open

Keywords: cardiovascular diseases; biomarkers; screening methods; sensor; spectroscopic methods; chromatographic methods

(This special issue belongs to the Section Medical Research)

Artificial Intelligence and Machine Learning for Biomedical Diagnostics and Prognostics

edited by

César Byron Guevara Maldonado

Victoria López

and

Diego Fernando Riofrío Luzcando

submission deadline 31 May 2026 | Viewed by 155 | Submission Open

Keywords: artificial intelligence; machine learning; diagnostic and prognostic modeling; multimodal data integration; explainable AI

(This special issue belongs to the Section Medical Research)

Understanding Early Dysmetabolism in Adolescents: Bridging Research, Mechanisms and Clinical Management

edited by Anna Di Sessa

submission deadline 31 May 2026 | Viewed by 123 | Submission Open

Keywords: dysmetabolism; biomarkers; intervention; prevention; early diagnosis; strategies; children; adolescents

(This special issue belongs to the Section Physiology and Pathology)

Objective Tools to Aid the Diagnosis and Treatment of Neurodevelopmental Disorders

edited by

Maria Pia Bucci

submission deadline 31 May 2026 | Viewed by 116 | Submission Open

Keywords: intervertion training ; eye tracker ; dyslexia ; postural sways ; reading ; ASD ; ADHD ; attention ; emotion

(This special issue belongs to the Section Medical Research)

Comorbidities of Migraine: Clinical and Research Perspectives

edited by

Claudio Tana

submission deadline 31 May 2026 | Viewed by 94 | Submission Open

Keywords: migraine; pain; headache; comorbidities; internal medicine; complex disorders

(This special issue belongs to the Section Medical Research)

Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Disorders

edited by Giovanni Tomasello

submission deadline 31 May 2026 | Viewed by 80 | Submission Open

Keywords: gut dysbiosis; gastrointestinal; probiotics; inflammatory bowel diseases

(This special issue belongs to the Section Microbiology)

Epidemiological Insights into Cardiovascular Risk and Outcomes

edited by Rui Providência

submission deadline 8 Jun 2026 | Viewed by 84 | Submission Open

Keywords: cohort study; Mendelian randomization; myocardial infarction; heart failure; stroke; atrial fibrillation; risk prediction

(This special issue belongs to the Section Epidemiology)

Agri-Food Waste Extracts: Structural and Functional Characterization

edited by

Stefania Lamponi

submission deadline 12 Jun 2026 | 1 articles | Viewed by 747 | Submission Open

Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules

(This special issue belongs to the Section Plant Science)

Ultrasound and Anatomical Studies

edited by

Maribel Miguel-Pérez

, Ingrid Moller and

Albert Pérez-Bellmunt

submission deadline 15 Jun 2026 | Viewed by 144 | Submission Open

Keywords: ultrasound techniques; musculoskeletal system; human anatomy; medicine specialties; clinical students; ultrasound teaching

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 18 Jun 2026 | 3 articles | Viewed by 7891 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Lipid Metabolism Pathways: From Life to Disease

edited by

Anna Eiring

submission deadline 19 Jun 2026 | 1 articles | Viewed by 5776 | Submission Open

Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Dive into Myopia

edited by

Chun-Fu Liu

submission deadline 19 Jun 2026 | 3 articles | Viewed by 4637 | Submission Open

Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles

(This special issue belongs to the Section Medical Research)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 20 Jun 2026 | Viewed by 179 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

(This special issue belongs to the Section Medical Research)

Advances in Knee Biomechanics—2nd Edition

edited by Jason Shearn

submission deadline 22 Jun 2026 | Viewed by 77 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 23 Jun 2026 | 7 articles | Viewed by 9296 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)

edited by

Yongseek Park

submission deadline 26 Jun 2026 | 1 articles | Viewed by 7164 | Submission Open

Keywords: chronic kidney disease; vascular dysfunction; endothelial cells

(This special issue belongs to the Section Medical Research)

Advances in Anesthesia and Critical Care

edited by

Gabriele Melegari

submission deadline 26 Jun 2026 | 5 articles | Viewed by 6533 | Submission Open

Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning

(This special issue belongs to the Section Medical Research)

Advances in Dryland Agriculture Science

edited by

Liangshan Feng

and Hangyu Dong

submission deadline 26 Jun 2026 | 3 articles | Viewed by 4011 | Submission Open

Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation

(This special issue belongs to the Section Plant Science)

Feature Papers in Medical Research: 4th Edition

edited by

Christian Lehmann

submission deadline 26 Jun 2026 | Viewed by 316 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research

edited by

Young Ah Goo

and

Byoung-Kyu Cho

submission deadline 26 Jun 2026 | Viewed by 86 | Submission Open

Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research

(This special issue belongs to the Section Medical Research)

Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition

edited by Paolo Scanagatta

submission deadline 26 Jun 2026 | 1 articles | Viewed by 84 | Submission Open

Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances

(This special issue belongs to the Section Medical Research)

Advanced Technologies and Clinical Practice of Cancer Radiotherapy

edited by

Marcin Balcerzyk

submission deadline 26 Jun 2026 | Viewed by 47 | Submission Open

Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Displaying special issue 301-350 on page 7 of 10.

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