Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.0
Journals
JPM
Special Issues
Radiation Oncology and Precision Medicine
share announcement

Radiation Oncology and Precision Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 109

Special Issue Editors

Dr. Justin Chunjoo Park

E-Mail Website
Guest Editor
Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA
Interests: radiation therapy; radiation oncology
Dr. Jiyeon Park

E-Mail Website
Guest Editor Assistant
1. University of Florida Health Proton Therapy Institute, Jacksonville, FL 32206, USA
2. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Interests: radiation therapy; particle therapy; radiological-interventional oncology (RIO); image-guided radiation therapy; adaptive radiation therapy

Special Issue Information

Dear Colleagues,

Radiation therapy (RT) has made remarkable progress through multidisciplinary research and cutting-edge technological innovations in science, yielding improved outcomes and enhanced patient experiences. Various powerful imaging techniques that enable adaptive radiation therapy (ART) are being leveraged to meet each patient's unique needs. This leads to timely and accurate detection of anatomical changes and real-time assessment of tumor responses. Furthermore, advanced treatment planning strategies have been developed to optimize the robustness of RT, taking into account each patient's treatment history, variations in alignment, anatomical changes, and organ motion.

This Special Issue will showcase clinical findings that demonstrate the impact of anatomical changes and dosimetric benefits achieved through advanced imaging in ART. It also covers the latest technological advancements in imaging and the clinical implementation of effective ART strategies to enhance patient alignment accuracy, optimize target localization, and facilitate online or offline assessment of anatomical changes. Furthermore, this Special Issue highlights disease-specific ART protocols grounded in evidence-based research, along with practical RT planning strategies that lead to improved treatment outcomes and better patient care.

We welcome scholars to submit reviews and original research articles related to radiological interventional oncology (RIO) and precision medicine.

Dr. Justin Chunjoo Park
Guest Editor

Dr. Jiyeon Park
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adaptive radiation therapy
  • image-guided radiation therapy
  • radiation oncology
  • precision medicine
  • multi-modal imaging
  • radiation treatment planning
  • tumor response

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Other

9 pages, 223 KB  
Brief Report
Radiotherapy with 5 × 5 Gy for Personalized Treatment of Malignant Epidural Compression of the Myelon: Long-Term Results of the PRE-MODE Trial
by Dirk Rades, Darejan Lomidze, Carlos Ferrer-Albiach, Antonio J. Conde-Moreno, Barbara Segedin, Blaz Groselj, Raquel Ciervide Jurio and Jon Cacicedo
J. Pers. Med. 2025, 15(12), 577; https://doi.org/10.3390/jpm15120577 (registering DOI) - 28 Nov 2025
Abstract
Background/Objectives: Despite increasing use of upfront decompressive surgery for malignant epidural compression of the myelon (MESCC), a substantial number of affected patients still receive radiotherapy (RT) alone. Many of these patients would benefit from a personalized treatment approach including the most appropriate dose-fractionation [...] Read more.
Background/Objectives: Despite increasing use of upfront decompressive surgery for malignant epidural compression of the myelon (MESCC), a substantial number of affected patients still receive radiotherapy (RT) alone. Many of these patients would benefit from a personalized treatment approach including the most appropriate dose-fractionation regimen. The PRE-MODE trial (NCT03070431) compared precision RT with 5 × 5 Gy (prospective cohort, n = 40) to conventional RT with 5 × 4 Gy (historical control, n = 676)). After propensity-score matching, 5 × 5 Gy resulted in significantly increased local progression-free survival (LPFS) at 6 months than 5 × 4 Gy. The question arose whether this benefit is still present after a longer period of follow-up. Methods: For this additional study, supplementary data were retrospectively captured, resulting in prolongation of follow-up until 24 months. Results: 5 × 5 Gy resulted in LPFS of 80.9% at each investigated time point (12, 18, and 24 months) without reported radiation myelopathy. Moreover, 5 × 5 Gy showed a trend towards improved LPFS after 12 (p = 0.070), 18 (p = 0.060), and 24 (p = 0.054) months. Similarly to the original PRE-MODE trial, OS-rates were not significantly different in the dose groups of this supplementary study. Conclusion: Since 5 × 5 Gy resulted in excellent long-term LPFS and showed a trend towards better outcomes up to 24 months following RT, it appears preferable to 5 × 4 Gy and will contribute to the personalized treatment of patients with MESCC who are assigned to RT alone without upfront neurosurgical intervention. Full article
(This article belongs to the Special Issue Radiation Oncology and Precision Medicine)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop