Novel Diagnostic and Therapeutical Opportunities for Asthma and Allergy

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (15 March 2025) | Viewed by 5187

Special Issue Editors


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Guest Editor
1. Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy
2. IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: allergology and clinical immunology; asthma; chronic rhinosinusitis with nasal polyps
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy
2. IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: allergy; anaphylaxis; drug allergy; asthma; severe asthma; rhinosinusitis with and without nasal polyps; biologicals; precision medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The management of allergies and, in particular, asthma has changed considerably since the advent of novel diagnostic and therapeutical opportunities. The therapeutic vision was modified from a “one size fits all” approach to an increased attention to tailored treatment strategies for patients affected by specific disease phenotypes to both reduce side effects and increase the therapeutic effect. This allowed for achieving more satisfactory clinical results and complete control of the diseases in an increasingly high proportion of allergic diseases. This novel personalized approach to allergic diseases requires a careful study of the endotype and phenotype in each single patient, with a multidisciplinary vision and increasingly sensitive biomarkers, with the need for more resources in terms of research, diagnostic time, and tools. The modern specialist's challenge is to achieve the maximum benefit for the patient with the minimum expense related to obtaining it. This Issue will collect articles on allergic diseases management and treatment, with particular attention to respiratory diseases considering the aspects described above.

Dr. Giovanni Paoletti
Dr. Enrico Marco Heffler
Guest Editors

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Keywords

  • allergy
  • asthma
  • severe asthma
  • precision medicine
  • multidisciplinary approach
  • tailored treatment

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Published Papers (2 papers)

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16 pages, 660 KiB  
Review
Prediction of Asthma Exacerbations in Children
by Evangelia Sarikloglou, Sotirios Fouzas and Emmanouil Paraskakis
J. Pers. Med. 2024, 14(1), 20; https://doi.org/10.3390/jpm14010020 - 22 Dec 2023
Cited by 6 | Viewed by 2753
Abstract
Asthma exacerbations are common in asthmatic children, even among those with good disease control. Asthma attacks result in the children and their parents missing school and work days; limit the patient’s social and physical activities; and lead to emergency department visits, hospital admissions, [...] Read more.
Asthma exacerbations are common in asthmatic children, even among those with good disease control. Asthma attacks result in the children and their parents missing school and work days; limit the patient’s social and physical activities; and lead to emergency department visits, hospital admissions, or even fatal events. Thus, the prompt identification of asthmatic children at risk for exacerbation is crucial, as it may allow for proactive measures that could prevent these episodes. Children prone to asthma exacerbation are a heterogeneous group; various demographic factors such as younger age, ethnic group, low family income, clinical parameters (history of an exacerbation in the past 12 months, poor asthma control, poor adherence to treatment, comorbidities), Th2 inflammation, and environmental exposures (pollutants, stress, viral and bacterial pathogens) determine the risk of a future exacerbation and should be carefully considered. This paper aims to review the existing evidence regarding the predictors of asthma exacerbations in children and offer practical monitoring guidance for promptly recognizing patients at risk. Full article
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15 pages, 521 KiB  
Protocol
RIAIT (Italian Registry of Allergen Immunotherapy): Protocol for a New Tool in a New Vision of Disease-Modifying Therapy for Allergists
by Giovanni Costanzo, Cristiano Caruso, Giovanni Paoletti, Ilaria Baglivo, Stefania Colantuono, Diego Bagnasco, Marco Caminati, Mattia Giovannini, Riccardo Castagnoli, Gianenrico Senna, Concetta Sirena, Maria Angela Tosca, Giovanni Passalacqua, Gian Luigi Marseglia, Michele Miraglia del Giudice, Giorgio Ciprandi, Cristiana Indolfi, Salvatore Barberi, Massimo Landi, Mario Di Gioacchino, Giorgio Walter Canonica and Enrico Heffleradd Show full author list remove Hide full author list
J. Pers. Med. 2024, 14(8), 854; https://doi.org/10.3390/jpm14080854 - 12 Aug 2024
Cited by 1 | Viewed by 1764
Abstract
Randomized controlled trials have demonstrated responses to clinical parameters, but a significant proportion of allergy patients in real-life settings would have been excluded from such studies. Therefore, real-world research is needed, and there is a growing body of information on allergen immunotherapy’s long-term [...] Read more.
Randomized controlled trials have demonstrated responses to clinical parameters, but a significant proportion of allergy patients in real-life settings would have been excluded from such studies. Therefore, real-world research is needed, and there is a growing body of information on allergen immunotherapy’s long-term effectiveness and safety. Real-world evidence can be a valuable instrument to better understand the patient’s journey and the effectiveness and safety of therapies. For this purpose, a registry will be used for the first time in Italy to evaluate the impact of allergen immunotherapy on several outcomes, including quality of life and disease-related effects in the pediatric and adult allergic population with a socio-economic assessment and respect to real-world health. Full article
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