Obstetrics and Gynecology: Integration of Surgical, Radiological, and Medical Therapies

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 1579

Special Issue Editors


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Guest Editor
Department of Maternal and Child Health, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy
Interests: gynaecologic oncology; gynaecological surgery; laparoscopic surgery; endometriosis; hysterectomy; screening; ovary

E-Mail Website
Guest Editor
Department of Maternal and Child Health, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy
Interests: gynaecology; gynaecology surgery; female healthcare; endometrial cancer; ovarian cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Moderate gynaecology must be based on a multifaceted approach, which is necessary for the effective management of complex gynaecological conditions. This Issue aims to bridge the traditional boundaries between surgery, radiology and medical treatments to provide a holistic perspective on patient care. In addition, artificial intelligence (AI) could have transformative potential in this field.

The main topics include the following:

- Innovative surgical techniques: Advances in minimally invasive and robotic surgery that improve precision and reduce recovery time.

- Interventional radiology: The role of image-guided procedures in the diagnosis and treatment of gynaecological disorders, reducing the need for more invasive surgery.

- Medical therapies: The latest pharmaceutical advances and their integration with surgical and radiological strategies to optimise treatment outcomes.

Through a collection of research articles and reviews, this Issue highlights the importance of a multidisciplinary approach, enhanced by the innovative use of AI, and shows how collaboration between different specialties can lead to better patient outcomes, more personalized treatment plans, and a better understanding of the complex interplay between various therapeutic modalities in gynaecology.

Dr. Martina Arcieri
Dr. Stefano Restaino
Guest Editors

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Keywords

  • gynaecology
  • surgical techniques
  • interventional radiology
  • medical therapies
  • multidisciplinary approach
  • treatment integration
  • personalized medicine
  • advanced therapeutics
  • collaborative care
  • multimodal therapy
  • clinical innovation

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Published Papers (1 paper)

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Research

11 pages, 1237 KiB  
Article
Endometrial E-cadherin and N-cadherin Expression during the Mid-Secretory Phase of Women with Ovarian Endometrioma or Uterine Fibroids
by Bo Seong Yun, Na Yeon Yun, Jung Eun Lee, Minyeon Go, Hee Yeon Jang, Ji Eun Park, Ju-Won Roh and Sung Shin Shim
J. Pers. Med. 2024, 14(9), 920; https://doi.org/10.3390/jpm14090920 - 29 Aug 2024
Cited by 2 | Viewed by 1124
Abstract
Background: Endometriosis and uterine fibroids are benign conditions frequently linked to subfertility/infertility. Recent research has highlighted the importance of epithelial–mesenchymal transition between embryonic and endometrial cells in the context of embryo implantation. Additionally, the adverse endometrial environment during implantation has been proposed as [...] Read more.
Background: Endometriosis and uterine fibroids are benign conditions frequently linked to subfertility/infertility. Recent research has highlighted the importance of epithelial–mesenchymal transition between embryonic and endometrial cells in the context of embryo implantation. Additionally, the adverse endometrial environment during implantation has been proposed as a mechanism contributing to infertility in endometriosis. Nevertheless, the role of cadherin molecule alterations in relation to endometrial receptivity and embryo invasion remains a subject of controversy. Methods: We investigated the expression patterns of E-cadherin and N-cadherin in the endometria of women with ovarian endometrioma or uterine fibroids and assessed whether they differed from those of healthy women. We enrolled 17 women with ovarian endometrioma, 16 with uterine fibroids, and 6 healthy women. Endometrial tissues were obtained at the mid-secretory phase on days 19–24 of the menstrual cycle. The E-cadherin and N-cadherin mRNA and protein expression levels were measured using quantitative reverse transcriptase polymerase chain reaction and Western blot analysis, respectively. Results: The E-cadherin and N-cadherin mRNA expression levels were higher and lower, respectively, in the endometrium of women with ovarian endometrioma than in those of the controls. In the endometrium of women with uterine fibroids, similar patterns with higher E-cadherin and lower N-cadherin levels were observed compared with that of the controls. Protein expression showed similar patterns. Conclusions: Our findings revealed higher E-cadherin expression and lower N-cadherin expression in the endometria of women with infertility-related diseases than in those of healthy women in the mid-secretory phase. This suggests a resistance to endometrial receptivity, potentially reflecting mesenchymal–epithelial transition properties. Full article
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