Personalized Treatments in Thoracic Oncology Surgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 10 January 2026 | Viewed by 1009

Special Issue Editors


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Guest Editor
Department of Cardiothoracic Surgery, University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany
Interests: non-small-cell lung carcinoma; pulmonary metastases; vascular diseases

E-Mail Website
Guest Editor
Department of Thoracic Surgery, St. Hildegardis Hospital Cologne, Cologne, Germany
Interests: non-small-cell lung carcinoma; segmentectomy; sleeve resection

Special Issue Information

Dear Colleagues,

Personalized medicine diverges from standard treatment regimens by tailoring interventions to the specific factors of individual patients. While personalized medicine can be applied across various medical fields, it is particularly well-suited to oncology. The significance of personalized oncological surgery is growing. Although minimally invasive approaches are currently the preferred methods in oncological surgery, personalized treatments in thoracic surgery extend beyond these techniques. They involve adapting surgical procedures to the tumor stage and customizing neoadjuvant and adjuvant therapies. Several factors significantly influence long-term survival, which have not been sufficiently addressed by the TNM classification. These factors should also be encompassed within the concept of personalized medicine.

This Special Issue aims to elucidate current developments in personalized thoracic surgery, including segmentectomy and subsegmentectomy, and to present the latest research on particular factors influencing long-term survival. We invite submissions of the latest original research and comprehensive reviews about all aspects of thoracic oncology surgery.

Dr. Georg Schlachtenberger
Dr. Alberto Lopez
Guest Editors

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Keywords

  • minimally invasive surgery
  • TNM classification
  • adjuvant treatment
  • long-term survival

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Published Papers (1 paper)

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Research

12 pages, 1035 KiB  
Article
Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study
by Hruy Menghesha, Donatas Zalepugas, Amina Camo, Georg Schlachtenberger, Konstantinos Grapatsas, Andres Amorin Estremadoyro, Fabian Doerr, Matthias Heldwein, Alexander Quaas, Servet Bölükbas, Gerardus Bennink, Joachim Schmidt and Khosro Hekmat
J. Pers. Med. 2025, 15(2), 67; https://doi.org/10.3390/jpm15020067 - 12 Feb 2025
Viewed by 653
Abstract
Objectives: While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification. With our study, we investigated the outcome of patients with pulmonary LCNEC and [...] Read more.
Objectives: While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification. With our study, we investigated the outcome of patients with pulmonary LCNEC and analyzed whether CK7 correlates with long-term survival. Methods: We retrospectively collected the monocentric data of patients which underwent anatomical resection for lung cancer between January 2012 and December 2020. Patients that did not show pulmonary LCNEC or adenocarcinoma, had a positive resection margin, or underwent neoadjuvant therapy were excluded. The long-term survival rate of the LCNEC and adenocarcinoma groups were compared before and after propensity score matching. Furthermore, we performed survival analyses for a subgroup of LCNEC distinguished by CK7 expression, followed by Cox regression analyses. Results: A total of 466 patients were integrated for further analysis. The mean age was 65.3 ± 9.6 years. There were no significant differences between both groups regarding age, gender, or comorbidities. In terms of the UICC stage, the groups were equally distributed. Mean survival in the LCNEC group was significantly worse than in the adenocarcinoma group (LCENC: 36.4 ± 7.5 months; adenocarcinoma: 80.7 ± 8.1 months; p-value = 0.001). The mean survival rate was 19.23 ± 4.8 months in the CK7 expression group and 57.01 ± 8.5 months in the group without expression, which reached statistical significance (p-value = 0.019). Conclusions: Our study suggests that pulmonary LCNEC has a significantly worse prognosis than pulmonary adenocarcinoma. CK7 expression seems to be correlated with a worse outcome for the long-term survival rate of patients suffering from highly malignant pulmonary LCNEC. Full article
(This article belongs to the Special Issue Personalized Treatments in Thoracic Oncology Surgery)
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