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Special Issues
Oxidative Stress and Antioxidant Therapy in Diseases
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Oxidative Stress and Antioxidant Therapy in Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 463

Special Issue Editors

Dr. Evgenia Lymperaki

E-Mail Website
Guest Editor
Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, Sindos, Greece
Interests: oxidative stress; reactive oxygen species; antioxidants; genetic profile; immunity; disease pathogenesis
Dr. Ioannis Tsamesidis

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Interests: oxidative stress; laboratory hematology; nanoparticles; stem cells differentiation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive Oxygen Species (ROS) are produced under normal physiological conditions in organisms and play a significant role in various biological functions, both beneficial and harmful. ROS can damage DNA, proteins, and lipids, leading to cellular dysfunction and disease. These reactive molecules are generated through both endogenous processes, such as cellular respiration, and exogenous sources, including UV radiation and environmental toxins. The body’s antioxidant system, which includes enzymes like catalase and superoxide dismutase as well as vitamins and minerals, serves to neutralize ROS and protect against oxidative stress. The aim of this Special Issue is to explore how the assessment of antioxidants and oxidants can facilitate the early diagnosis and prevention of diseases linked to oxidative stress. By understanding the oxidative status of patients, we can develop strategies to mitigate disease progression and enhance preventative measures. This Special Issue seeks to present cutting-edge research that delves into the mechanisms by which oxidative stress contributes to disease and examines innovative methods for testing and analyzing antioxidant and oxidant levels. We are particularly interested in studies that demonstrate how these assessments can be used to predict disease onset, monitor progression, and evaluate the effectiveness of therapeutic interventions.

Dr. Evgenia Lymperaki
Dr. Ioannis Tsamesidis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • ROS
  • diseases
  • antioxidants

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Published Papers (1 paper)

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Research

15 pages, 976 KiB  
Article
Oxidative Stress Biomarkers as Preclinical Markers of Mild Cognitive Impairment: The Impact of Age and Sex
by Stavroula Ioannidou, Magda Tsolaki, Argyrios Ginoudis, Androniki Tamvakis, Anthoula Tsolaki, Kali Makedou and Evgenia Lymperaki
J. Pers. Med. 2025, 15(5), 171; https://doi.org/10.3390/jpm15050171 - 26 Apr 2025
Viewed by 151
Abstract
Background: Reactive oxygen species (ROS) are involved in the pathophysiology of neurodegeneration and cognitive decline, indicating the potential use of oxidative stress biomarkers for early diagnosis. Mild cognitive impairment (MCI) is defined as a cognitive decline beyond normal aging, without significant impact on [...] Read more.
Background: Reactive oxygen species (ROS) are involved in the pathophysiology of neurodegeneration and cognitive decline, indicating the potential use of oxidative stress biomarkers for early diagnosis. Mild cognitive impairment (MCI) is defined as a cognitive decline beyond normal aging, without significant impact on daily functioning, and is considered an important stage of early detection of neurodegeneration. This study aimed to investigate serum and cerebrospinal fluid (CSF) levels of oxidative stress biomarkers, total ROS and malondialdehyde (MDA) in patients with MCI to evaluate their utility in the early diagnosis of Alzheimer’s disease (AD). Levels of oxidative stress biomarkers were also assessed according to age and sex, as well as their correlation with the established CSF biomarkers, including amyloid-beta (Aβ40, Aβ42 and Aβ42/Aβ40 ratio), phosphorylated tau protein (p-tau) and total tau (t-tau). Methods: A total of 114 adults were divided into three groups: MCI (A−) patients with a normal CSF Aβ42/Aβ40 ratio (n = 38), MCI (A+) patients with an abnormal Aβ42/Aβ40 ratio (n = 38) and healthy cognitive function individuals with a normal Aβ42/Aβ40 ratio (n = 38). Established CSF biomarkers were conducted using an automated immunochemical method, while total ROS levels were measured by fluorometry and MDA levels were determined by competitive inhibition enzyme immunoassay. Results: A statistically significant difference was observed in CSF MDA levels (p < 0.05) and serum ROS levels (p < 0.05) between the study groups. Sex analysis revealed significantly higher levels of CSF MDA levels in the MCI (A+) males’ group (p < 0.05). In terms of age categorization, serum MDA levels were markedly higher in the MCI (A+) group of older patients (p < 0.01). Conclusions: These findings highlight the importance of individualized approaches, including investigation of oxidative stress biomarkers profile to prevent and manage individuals in the early stages of MCI, considering demographic factors. Full article
(This article belongs to the Special Issue Oxidative Stress and Antioxidant Therapy in Diseases)
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