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Personalized Therapeutic Advances in Neuro-Oncology and Neurosurgery
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Personalized Therapeutic Advances in Neuro-Oncology and Neurosurgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 2488

Special Issue Editor

Dr. Safwan Alomari

E-Mail Website
Guest Editor
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Interests: neurosurgery; glioma; spinal cord injury; neurooncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, personalized medicine has been increasingly incorporated into neuro-oncology and neurosurgery. Basic and translational research in the fields of genetics, molecular biology, transcriptomics, proteomics and metabolomics play a crucial role in the diagnosis and treatment of different diseases.

This Special Issue, entitled “Personalized Therapeutic Advances in Neuro-Oncology and Neurosurgery”, aims to discuss the prevention, diagnosis, risk assessment, personalized treatment and future trends in neuro-oncology and neurosurgery. We encourage researchers (clinicians and scientists) in these fields to submit original articles or reviews to this Special Issue of the Journal of Personalized Medicine.

Topics may include (but are not limited to) the following:

personalized medicine in glioblastomas; meningiomas; pituitary tumors; spinal cord injury; neuro-imaging; genomics, proteomic, inflammation of neurological and neurosurgical diseases; and epigenetics and microRNAs of neuro-oncology and neurosurgical diseases.

Dr. Safwan Alomari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurosurgery
  • neuro-oncology
  • brain tumor
  • neuro-imaging
  • glioma
  • spinal cord injury
  • personalized medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

15 pages, 2044 KiB  
Article
The 3-Steps Approach for Lumbar Stenosis with Anatomical Insights, Tailored for Young Spine Surgeons
by Giuseppe La Rocca, Gianluca Galieri, Edoardo Mazzucchi, Fabrizio Pignotti, Vittorio Orlando, Simona Pappalardo, Alessandro Olivi and Giovanni Sabatino
J. Pers. Med. 2024, 14(9), 985; https://doi.org/10.3390/jpm14090985 - 16 Sep 2024
Cited by 2 | Viewed by 788
Abstract
Background/Objectives: Lumbar decompression surgery for degenerative lumbar stenosis is an intervention which addresses a degenerative condition affecting many patients. This article presents a meticulous three-phase surgical approach, derived from our clinical experiences and intertwining anatomical insights, offering a nuanced perspective tailored for [...] Read more.
Background/Objectives: Lumbar decompression surgery for degenerative lumbar stenosis is an intervention which addresses a degenerative condition affecting many patients. This article presents a meticulous three-phase surgical approach, derived from our clinical experiences and intertwining anatomical insights, offering a nuanced perspective tailored for the educational needs of young spinal surgeons. Methods: Six hundred and eighty-seven patients who underwent lumbar decompression surgery at a single institution were included in the present study. A retrospective analysis of patient demographics and surgical techniques was performed. All surgeries were performed by a consistent surgical team, emphasizing uniformity in approach. The surgical technique involves a meticulous three-phase process comprising exposure and skeletal visualization; microscopic identification and decompression; and undermining of the spinous process base and contralateral decompression. Results: Presenting results from 530 patients, the study examines demographic characteristics, health profiles, operative details, complications, and clinical assessments. The three-phase approach demonstrates low complication rates, absence of recurrences, and improved clinical outcomes, emphasizing its efficacy. Conclusions: The three-phase surgical approach emerges as a valuable educational tool for both novice and seasoned spinal surgeons. Rooted in anatomical insights, the structured methodology not only caters to the educational needs of young surgeons, but also ensures a standardized and safe procedure. The emphasis on tissue preservation and anatomical points aligns with current trends toward minimally invasive techniques, promising enhanced patient outcomes and satisfaction. Full article
(This article belongs to the Special Issue Personalized Therapeutic Advances in Neuro-Oncology and Neurosurgery)
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9 pages, 1249 KiB  
Article
Mindfulness vs. Physiotherapy vs. Medical Therapy: Uncovering the Best Postoperative Recovery Method for Low Back Surgery Patients during the COVID-19 Pandemic—A Single Institution’s Experience
by Giuseppe La Rocca, Vittorio Orlando, Gianluca Galieri, Edoardo Mazzucchi, Fabrizio Pignotti, Davide Cusumano, Paola Bazzu, Alessandro Olivi and Giovanni Sabatino
J. Pers. Med. 2024, 14(9), 917; https://doi.org/10.3390/jpm14090917 - 29 Aug 2024
Cited by 2 | Viewed by 1292
Abstract
Introduction: This study aimed to evaluate the efficacy of mindfulness therapy compared to traditional physiotherapy and usual care in alleviating postoperative pain and improving functional outcomes in patients undergoing lumbar spine surgery during the COVID-19 pandemic. Methods: Ninety patients undergoing lumbar decompression and [...] Read more.
Introduction: This study aimed to evaluate the efficacy of mindfulness therapy compared to traditional physiotherapy and usual care in alleviating postoperative pain and improving functional outcomes in patients undergoing lumbar spine surgery during the COVID-19 pandemic. Methods: Ninety patients undergoing lumbar decompression and fusion (LDF) who presented persistent low back pain after surgery were prospectively followed for one year. They were randomly divided into three groups: mindfulness therapy, physiotherapy, and medical therapy. The primary outcome was the improvement of the Oswestry Disability Index (ODI) score postoperatively and at six months follow-up. Results: Both mindfulness and physiotherapy groups showed significant improvement in ODI scores compared to the control group, with mean variations of 10.6 and 11.6 points, respectively, versus 4.9 points in the control group. There was no significant difference between mindfulness and physiotherapy (p = 0.52), but both were superior to medical care (p < 0.0001 for physiotherapy and p = 0.0007 for mindfulness). Conclusions: This study demonstrated that mindfulness therapy is more effective than usual care in improving postoperative outcomes for patients undergoing lumbar spine surgery. In our cohort, its efficacy was comparable to that of physiotherapy, making it a viable alternative, especially when access to healthcare services is restricted, as seen during the COVID-19 pandemic. Future research should validate the findings of this study and examine the long-term effects on surgical patient populations. Full article
(This article belongs to the Special Issue Personalized Therapeutic Advances in Neuro-Oncology and Neurosurgery)
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