Navigating the Evolving Landscape of Gynecology: From Diagnosis to Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (15 July 2025) | Viewed by 777

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynaecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, 95124 Catania, Italy
Interests: obstetrics; gynaecology; reproductive medicine
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Special Issue Information

Dear Colleagues,

In the dynamic field of gynecology, the journey from diagnosis to treatment has been significantly shaped by advancements in medical technology, evolving diagnostic criteria, and innovative therapeutic modalities. This journey encompasses a spectrum of conditions and concerns that are unique to the female reproductive system, ranging from routine screenings for cervical cancer to complex fertility treatments and the management of menopausal symptoms.

Over the past decades, the landscape of gynecological care has witnessed remarkable transformations, propelled by breakthroughs in medical research and a deeper understanding of women’s health needs. In this update, we embark on an exploration of the latest developments that define contemporary gynecology, tracing the trajectory from precise diagnostic techniques to tailored treatment strategies.

At the heart of this discussion lies the pivotal role of accurate diagnosis, which serves as the cornerstone for the effective management of gynecological conditions. Advances in imaging technologies, such as ultrasound and magnetic resonance imaging (MRI), have revolutionized the diagnostic armamentarium, enabling clinicians to visualize anatomical structures with unprecedented clarity and precision. Additionally, molecular and genetic testing have ushered in a new era of personalized medicine, allowing for targeted interventions based on individual genetic profiles and biomarker analysis.

Furthermore, the journey from diagnosis to treatment encompasses a diverse array of therapeutic modalities, ranging from pharmacological interventions to minimally invasive surgical techniques. In recent years, there has been a paradigm shift towards conservative management approaches, emphasizing the preservation of fertility and quality of life. This shift is particularly evident in the management of conditions such as endometriosis and uterine fibroids, where innovative medical therapies and minimally invasive procedures offer alternatives to traditional surgical interventions.

Moreover, the landscape of gynecological oncology has been transformed by advancements in precision medicine and immunotherapy, ushering in a new era of personalized cancer care. From targeted molecular therapies to novel immunomodulatory agents, these groundbreaking treatments hold promise for improved outcomes and enhanced quality of life for women with gynecological malignancies.

In this update on gynecology, we embark on a comprehensive journey from diagnosis to treatment, exploring the latest advancements that shape the landscape of women’s health care. By delving into the intricate interplay between cutting-edge diagnostics and innovative therapeutic modalities, we aim to provide insights into the evolving landscape of gynecological care and its profound impact on patient outcomes and well-being. Therefore, original articles, reviews, and meta-analyses are welcome in this Special Issue.

Dr. Ferdinando Antonio Gulino
Dr. Stefano Cianci
Guest Editors

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Keywords

  • gynecology
  • precision medicine
  • gynecologic oncology
  • women health
  • cancer prevention
  • minimally invasive gynecology

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Published Papers (1 paper)

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Research

8 pages, 367 KiB  
Article
Fetal Thigh Circumference Nomograms Across Gestational Ages: A Retrospective Study
by Ferdinando Antonio Gulino, Giorgio Arcarese, Giosuè Giordano Incognito, Giuliana Orlandi, Olimpia Gabrielli, Antonia Lettieri, Luigi Manzo, Laura Letizia Mazzarelli, Giordana Sica, Letizia Di Meglio, Lavinia Di Meglio, Attilio Tuscano, Sara Occhipinti, Maurizio Guida and Aniello Di Meglio
J. Pers. Med. 2025, 15(7), 265; https://doi.org/10.3390/jpm15070265 - 22 Jun 2025
Viewed by 215
Abstract
Background/Objectives: Fetal thigh circumference (ThC) may be a valuable parameter for assessing fetal growth. Thus, this study aimed to establish reference ranges for ThC across gestational ages (GA). Methods: This retrospective study included singleton pregnancies between 12 and 38 weeks of [...] Read more.
Background/Objectives: Fetal thigh circumference (ThC) may be a valuable parameter for assessing fetal growth. Thus, this study aimed to establish reference ranges for ThC across gestational ages (GA). Methods: This retrospective study included singleton pregnancies between 12 and 38 weeks of gestation. ThC measurements were obtained during routine ultrasound examinations. GA was confirmed through the last menstrual period and first-trimester crown–rump length measurements. Percentile ranges for ThC were calculated for each gestational week, and statistical analyses evaluated the relationship between ThC and GA. Results: 48,841 singleton pregnancies were included. A positive correlation was observed between ThC and GA, with ThC values increasing progressively from 12 to 38 weeks. The study established the 10th, 50th, and 90th percentile ranges for ThC, providing reference values for clinical assessments. Conclusions: This study provides reference ranges for fetal ThC across a wide GA range, highlighting its potential as a tool in prenatal care. ThC may offer an additional parameter for monitoring fetal growth, especially when standard measurements are challenging. Further research should investigate the integration of ThC with other fetal growth parameters to enhance its clinical utility. Additionally, these nomograms can be used to assess their usefulness in certain conditions, such as intrauterine growth restriction (IUGR), macrosomia, and congenital skeletal dysplasias. Full article
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