Nanomaterials in Bone Tissue Engineering and Regenerative Medicine Applications

Dear Colleagues,

Recent advances in nanotechnology are driving a new generation of bone tissue engineering scaffolds with unprecedented multifunctionality and bioactivity. Nanomaterials including bioactive metals, ceramics, polymers, and carbon-based nanostructures are often being engineered in composite forms to mimic the bone’s hierarchical structure, mechanical properties, and biochemical cues. Innovative engineering tools such as Electrospinning and 3D Printing enable precise control over scaffold architecture from the nano- to macro-scale, while chemical synthesis yields bioactive nanoparticles that can be embedded or coated onto scaffolds. Nanoscale surface modifications (e.g., bioactive coatings or topographical patterning) further enhance cell adhesion, osteoinductive potential, and antimicrobial performance. As a result, nanostructured biomaterials actively promote osteogenic differentiation and angiogenesis, providing the necessary cues for vascularized bone regeneration even in large defects. By integrating structural support with bioactive signaling and therapeutic delivery, these advanced materials demonstrate the multifunctional approach needed to improve bone repair outcomes. Ongoing research highlights their translational promise, bringing these nanoscaffolds closer to clinical application in complex bone repair scenarios. With the aim of advancing bone tissue regeneration through next-generation biomaterials, this Special Issue emphasizes novel scaffold designs, biocompatible material integration, and strategies for both hard and soft tissue reconstruction.

Dr. Rupesh Kandel
Dr. Ismat Ullah
Guest Editors

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