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Biomaterials Applications in Bone and Wound Repair
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Biomaterials Applications in Bone and Wound Repair

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4213

Special Issue Editors

Prof. Dr. Guohui Liu

E-Mail Website
Guest Editor
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Interests: basic and clinical research on soft tissue and bone defect repair; tissue engineering; mechanism and countermeasure of osteoblast/osteoclast imbalance in osteoporosis
Prof. Dr. Bobin Mi

E-Mail Website
Guest Editor
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Interests: fracture repair; exosome; biomaterials

Special Issue Information

Dear Colleagues,

The ability to regenerate damaged tissues has attracted an increasing number of researchers. Although tissue engineering has been widely recommended in the field of regeneration, several limitations remain, such as poor biocompatibility or inevitable immune reaction to the host. Recently, cell or nano-scaled secretions (i.e., exosomes)-encapsulated biomaterials have been found to have increasing regenerative potential in several tissues, in which hydrogels have been proven to be the most economical and accessible material. In this Topic, original research articles and reviews are welcome. Research areas may include (but are not limited to) recent advances in biomaterials and the application of biomaterials to promote wound or fracture healing. We look forward to receiving your contributions.

Prof. Dr. Guohui Liu
Prof. Dr. Bobin Mi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • hydrogels
  • exosomes
  • fracture and wound repair

Published Papers (1 paper)

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Review

27 pages, 2979 KiB  
Review
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
by Yingkun Hu, Jinghuan Huang, Chunying Chen, Yi Wang, Zhuowen Hao, Tianhong Chen, Junwu Wang and Jingfeng Li
J. Funct. Biomater. 2023, 14(1), 18; https://doi.org/10.3390/jfb14010018 - 29 Dec 2022
Cited by 6 | Viewed by 3935
Abstract
Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance between bone resorption and bone formation. The regulation of physiological bone remodeling by a complex system that involves multiple cells in the skeleton is closely related to bone homeostasis. Loss [...] Read more.
Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance between bone resorption and bone formation. The regulation of physiological bone remodeling by a complex system that involves multiple cells in the skeleton is closely related to bone homeostasis. Loss of bone mass or repair of bone is always accompanied by changes in bone homeostasis. However, due to the complexity of bone homeostasis, we are currently unable to identify all the mechanisms that affect bone homeostasis. To date, bone macrophages have been considered a third cellular component in addition to osteogenic spectrum cells and osteoclasts. As confirmed by co-culture models or in vivo experiments, polarized or unpolarized macrophages interact with multiple components within the bone to ensure bone homeostasis. Different macrophage phenotypes are prone to resorption and formation of bone differently. This review comprehensively summarizes the mechanisms by which macrophages regulate bone homeostasis and concludes that macrophages can control bone homeostasis from osteoclasts, mesenchymal cells, osteoblasts, osteocytes, and the blood/vasculature system. The elaboration of these mechanisms in this narrative review facilitates the development of macrophage-based strategies for the treatment of bone metabolic diseases and bone defects. Full article
(This article belongs to the Special Issue Biomaterials Applications in Bone and Wound Repair)
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