Biopolymers for Drug Delivery Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 2756

Special Issue Editors


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Guest Editor
College of Pharmacy, University of Arizona, Tucson, AZ, USA
Interests: pharmaceutical technology; polymer-drug conjugate; nanoparticles; self-assembly; microparticles; carbohydrate polymers; targeted drug delivery; ionic liquids; pharmaceutical chemistry; prodrugs; polym

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Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
Interests: sustainable polymers; biocompatible polymer systems; biodegradable polymers; bioactive oligomers; controlled drug delivery systems; ring-opening polymerization; polymers for biomedical applications
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Special Issue Information

Dear Colleagues,

The growing interest in utilizing biopolymers for developing drug delivery systems stems from their notable and multifaceted advantages, setting them apart from conventional polymers. Biopolymers offer a plethora of benefits, including biodegradability, biocompatibility, renewability, affordability, and widespread availability, all of which are crucial for creating materials applicable in the biomedical realm. Derived from natural sources, such as plants, animals, or microorganisms, biopolymers have gathered substantial attention in innovative drug delivery systems, including oral, parenteral, and transdermal routes. These systems enable increased drug payload, controlled drug release, and targeted drug delivery as well as cytocompatibility, showcasing the versatility and potential of biopolymers in modern pharmaceutical applications.

The primary aim of this Special Issue, on “Biopolymers for Drug Delivery Applications”, is to compile recent discoveries and advancements in biopolymers for drug delivery purposes. It welcomes contributions in the form of original research or review articles, encompassing a wide spectrum of biopolymer research. Topics of interest include, but are not limited to, the chemical modifications of biopolymers; their synthesis, characterization, and application; preparations of targeted biopolymer-based drug delivery; the delivery of biomaterials; and novel drug delivery strategies aimed at enhancing the adaptability and safety of biopolymers.

Dr. Yogesh Baburao Sutar
Prof. Dr. Piotr Kurcok
Guest Editors

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Keywords

  • biopolymer
  • drug delivery
  • nanoparticles
  • controlled release
  • biopolymer modification
  • crosslinking
  • drug conjugate
  • targeted drug delivery

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Published Papers (1 paper)

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Research

12 pages, 2451 KiB  
Article
Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections
by Juhaina M. Abu Ershaid, Han Zhang, May Tayyem, Akmal H. Sabri, Ryan F. Donnelly and Lalitkumar K. Vora
J. Funct. Biomater. 2024, 15(11), 316; https://doi.org/10.3390/jfb15110316 - 25 Oct 2024
Cited by 1 | Viewed by 2096
Abstract
Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer [...] Read more.
Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles. Methods: This study focused on the use of sodium alginate MNs for vancomycin delivery directly to the site of infection via a cost-effective micromolding technique. Dissolving polymeric MNs made of sodium alginate and loaded with vancomycin were fabricated and evaluated in terms of their physical properties, delivery ability, and antimicrobial activity. Results: The MNs achieved a 378 μm depth of insertion into ex vivo skin and a 5.0 ± 0 mm zone of inhibition in agar disc diffusion assays. Furthermore, in ex vivo Franz cell experiments, the MNs delivered 34.46 ± 11.31 μg of vancomycin with around 35% efficiency, with 9.88 ± 0.57 μg deposited in the skin after 24 h. Conclusions: These findings suggest that sodium alginate MNs are a viable platform for antimicrobial agent delivery in SSTIs. Future in vivo studies are essential to confirm the safety and effectiveness of this innovative method for clinical use. Full article
(This article belongs to the Special Issue Biopolymers for Drug Delivery Applications)
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