Journal of Functional Biomaterials

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Bioactive Glasses and Their Multiple Applications in Biomedicine

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Dr. Xin Liu

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Department of Dental Materials, Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: biomaterials; bioactive glasses; dental materials; tissue regeneration; cancer treatment; biological evaluation; antibacterial nanomaterials

Special Issue Information

Dear Colleagues,

Bioactive glasses have been widely investigated in various biomedicine fields such as tissue regeneration, cancer treatment and dentistry due to their excellent biocompatibility, antibacterial properties and bioactivity. However, the clinical translation of bioactive glasses is still limited by their disadvantages, including low mechanical strength and high solubility. Therefore, the demand for exploiting bioactive glasses in multiple biomedical applications is growing. Currently, numerous efforts are being devoted to improving the mechanical and biological performance of bioactive glasses through various strategies such as doping therapeutic ions (e.g., boron, copper, cobalt, silver, zinc, strontium and cerium), incorporating inorganic biomaterials, tailoring crystallization or modifying the structure. In this Special Issue, entitled “Bioactive Glasses and Their Multiple Applications in Biomedicine”, we welcome original research articles, reviews, short communications or bioinformatics/analysis research articles to be submitted to our collection of the latest studies focusing on innovative biomaterials and cutting-edge technologies related to bioactive glasses in various biomedical applications. Topics may include, but are not limited to, the availability of therapeutic ions with improved biofunctionality (e.g., tissue regeneration, antibacterial ability, mineralization and antitumor activity); advanced technologies for synthesis and modification to improve mechanical properties; the mechanism underlying the biological behaviors of bioactive glasses; and the biocompatibility, functional evaluation and clinical translation of bioactive glasses from bench to clinic.

Dr. Xin Liu
Guest Editor

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15 pages, 8168 KiB

Open AccessArticle

Evaluating the Translucency, Surface Roughness, and Cytotoxicity of a PMMA Acrylic Denture Base Reinforced with Bioactive Glasses

by Abdulaziz Alhotan, Zbigniew Raszewski, Katarzyna Chojnacka, Marcin Mikulewicz, Julita Kulbacka, Razan Alaqeely, Amani Mirdad and Julfikar Haider

J. Funct. Biomater. 2024, 15(1), 16; https://doi.org/10.3390/jfb15010016 - 31 Dec 2023

Cited by 2 | Viewed by 2487

Abstract

The colonisation of the surface of removable acrylic dentures by various types of microorganisms can lead to the development of various diseases. Therefore, the creation of a bioactive material is highly desirable. This study aimed to develop a denture base material designed to release bioactive ions into the oral environment during use. Four types of bioactive glasses (BAG)—S53P4, Biomin F, 45S5, and Biomin C—were incorporated into the PMMA acrylic resin, with each type constituting 20 wt.% (10 wt.% non-silanised and 10% silanised) of the mixture, while PMMA acrylic resin served as the control group. The specimens were subsequently immersed in distilled water, and pH measurements of the aqueous solutions were taken every seven days for a total of 38 days. Additionally, surface roughness and translucency measurements were recorded both after preparation and following seven days of immersion in distilled water. The cytotoxicity of these materials on human fibroblast cells was evaluated after 24 and 48 h using Direct Contact and MTT assays. Ultimately, the elemental composition of the specimens was determined through energy-dispersive X-ray (EDX) spectroscopy. In general, the pH levels of water solutions containing BAG-containing acrylics gradually increased over the storage period, reaching peak values after 10 days. Notably, S53P4 glass exhibited the most significant increase, with pH levels rising from 5.5 to 7.54. Surface roughness exhibited minimal changes upon immersion in distilled water, while a slight decrease in material translucency was observed, except for Biomin C. However, significant differences in surface roughness and translucency were observed among some of the BAG-embedded specimens under both dry and wet conditions. The composition of elements declared by the glass manufacturer was confirmed by EDX analysis. Importantly, cytotoxicity analysis revealed that specimens containing BAGs, when released into the environment, did not adversely affect the growth of human gingival fibroblast cells after 48 h of exposure. This suggests that PMMA acrylics fabricated with BAGs have the potential to release ions into the environment and can be considered biocompatible materials. Further clinical trials are warranted to explore the practical applications of these materials as denture base materials. Full article

(This article belongs to the Special Issue Bioactive Glasses and Their Multiple Applications in Biomedicine)

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