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Bioactive Glasses and Their Multiple Applications in Biomedicine
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Bioactive Glasses and Their Multiple Applications in Biomedicine

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 20 June 2024 | Viewed by 2141

Special Issue Editor

Dr. Xin Liu

E-Mail Website
Guest Editor
Department of Dental Materials, Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: biomaterials; bioactive glasses; dental materials; tissue regeneration; cancer treatment; biological evaluation; antibacterial nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive glasses have been widely investigated in various biomedicine fields such as tissue regeneration, cancer treatment and dentistry due to their excellent biocompatibility, antibacterial properties and bioactivity. However, the clinical translation of bioactive glasses is still limited by their disadvantages, including low mechanical strength and high solubility. Therefore, the demand for exploiting bioactive glasses in multiple biomedical applications is growing. Currently, numerous efforts are being devoted to improving the mechanical and biological performance of bioactive glasses through various strategies such as doping therapeutic ions (e.g., boron, copper, cobalt, silver, zinc, strontium and cerium), incorporating inorganic biomaterials, tailoring crystallization or modifying the structure. In this Special Issue, entitled “Bioactive Glasses and Their Multiple Applications in Biomedicine”, we welcome original research articles, reviews, short communications or bioinformatics/analysis research articles to be submitted to our collection of the latest studies focusing on innovative biomaterials and cutting-edge technologies related to bioactive glasses in various biomedical applications. Topics may include, but are not limited to, the availability of therapeutic ions with improved biofunctionality (e.g., tissue regeneration, antibacterial ability, mineralization and antitumor activity); advanced technologies for synthesis and modification to improve mechanical properties; the mechanism underlying the biological behaviors of bioactive glasses; and the biocompatibility, functional evaluation and clinical translation of bioactive glasses from bench to clinic.

Dr. Xin Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive glasses
  • therapeutic inorganic ions
  • tissue regeneration
  • antibacterial property
  • cancer treatment
  • biomedical applications

Published Papers (1 paper)

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Research

15 pages, 8168 KiB  
Article
Evaluating the Translucency, Surface Roughness, and Cytotoxicity of a PMMA Acrylic Denture Base Reinforced with Bioactive Glasses
by Abdulaziz Alhotan, Zbigniew Raszewski, Katarzyna Chojnacka, Marcin Mikulewicz, Julita Kulbacka, Razan Alaqeely, Amani Mirdad and Julfikar Haider
J. Funct. Biomater. 2024, 15(1), 16; https://doi.org/10.3390/jfb15010016 - 31 Dec 2023
Viewed by 1545
Abstract
The colonisation of the surface of removable acrylic dentures by various types of microorganisms can lead to the development of various diseases. Therefore, the creation of a bioactive material is highly desirable. This study aimed to develop a denture base material designed to [...] Read more.
The colonisation of the surface of removable acrylic dentures by various types of microorganisms can lead to the development of various diseases. Therefore, the creation of a bioactive material is highly desirable. This study aimed to develop a denture base material designed to release bioactive ions into the oral environment during use. Four types of bioactive glasses (BAG)—S53P4, Biomin F, 45S5, and Biomin C—were incorporated into the PMMA acrylic resin, with each type constituting 20 wt.% (10 wt.% non-silanised and 10% silanised) of the mixture, while PMMA acrylic resin served as the control group. The specimens were subsequently immersed in distilled water, and pH measurements of the aqueous solutions were taken every seven days for a total of 38 days. Additionally, surface roughness and translucency measurements were recorded both after preparation and following seven days of immersion in distilled water. The cytotoxicity of these materials on human fibroblast cells was evaluated after 24 and 48 h using Direct Contact and MTT assays. Ultimately, the elemental composition of the specimens was determined through energy-dispersive X-ray (EDX) spectroscopy. In general, the pH levels of water solutions containing BAG-containing acrylics gradually increased over the storage period, reaching peak values after 10 days. Notably, S53P4 glass exhibited the most significant increase, with pH levels rising from 5.5 to 7.54. Surface roughness exhibited minimal changes upon immersion in distilled water, while a slight decrease in material translucency was observed, except for Biomin C. However, significant differences in surface roughness and translucency were observed among some of the BAG-embedded specimens under both dry and wet conditions. The composition of elements declared by the glass manufacturer was confirmed by EDX analysis. Importantly, cytotoxicity analysis revealed that specimens containing BAGs, when released into the environment, did not adversely affect the growth of human gingival fibroblast cells after 48 h of exposure. This suggests that PMMA acrylics fabricated with BAGs have the potential to release ions into the environment and can be considered biocompatible materials. Further clinical trials are warranted to explore the practical applications of these materials as denture base materials. Full article
(This article belongs to the Special Issue Bioactive Glasses and Their Multiple Applications in Biomedicine)
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