Biomaterials in Regenerative Medicine: Design, Functionality, and Biomedical Potential

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Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: biocompatibility; regenerative medicine; tissue egineering; cell biology; biochemistry; cell biomaterial interactions

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Guest Editor
Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: functional biomaterials; biocompatibility; tissue engineering; regenerative medicine; cell biology; biomedical materials
Special Issues, Collections and Topics in MDPI journals

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National Institute for Lasers, Plasma, and Radiation Physics, Bucharest, Romania
Interests: biomaterials; laser pracessing; MAPLE; LIFT; composite; biointerfaces; smart coatings
Special Issues, Collections and Topics in MDPI journals

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Special Issue Information

Dear Colleagues,

In the last few decades, regenerative medicine has emerged as a transformative field with the potential to restore or replace damaged tissues and organs, offering promising alternatives to current traditional treatment approaches. Central to this progress is the development of advanced biomaterials that can support tissue regeneration by mimicking the extracellular matrix, modulating cellular responses, and enabling the delivery of bioactive molecules.

This Special Issue, "Biomaterials in Regenerative Medicine: Design, Functionality, and Biomedical Potential," focuses on the convergence of material processing technologies, emphasizing materials innovation, biofabrication strategies, functional integration, and translational potential.  Success in this field requires an interdisciplinary approach that carefully considers material design, biological functionality, and long-term regenerative outcomes.

Key areas of interest include but are not limited to (i) novel design strategies for biomaterials (e.g., alloys; ceramics; polymers; hydrogels; and composites) with tunable mechano-chemical and biological characteristics; (ii) surface functionalization strategies for improved biocompatibility and cell behavior guidance; (iii) smart or stimuli-responsive biomaterials capable of interacting with the biological environment; (iv) biomaterials as delivery systems; and (v) in vitro and in vivo studies on biomaterials focusing on immune modulation, regenerative potential, and applications in cancer therapy. 

We welcome the submission of original research, review articles, and short communications that point out the interdisciplinary efforts to create novel biomaterials, scaffolds, advanced manufacturing techniques, and clinically relevant applications. By bridging fundamental material science with biomedical applications, this Special Issue aims to provide a comprehensive view of how cutting-edge biomaterials are driving new frontiers in regenerative medicine.

We look forward to your valuable submissions.

Dr. Valentina Mitran
Dr. Andreea-Mariana Negrescu
Dr. Valentina Dinca
Prof. Dr. Anişoara Cîmpean
Guest Editors

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Keywords

  • biocompatibility
  • tissue engineering
  • biomaterial design
  • regenerative medicine
  • drug delivery systems
  • biomaterials/biointerface characterization
  • in vitro and in vivo evaluation

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Published Papers (1 paper)

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Research

19 pages, 9448 KB  
Article
Effects of Hydrodynamic Ozonated Water Processing on the Thermal Stability and Structural Integrity of the Human Amniotic Membrane
by Marcia Guelma Santos Belfort, Francisco Dimitre Rodrigo Pereira Santos, Maycon Crispim de Oliveira Carvalho, Aline Casarin dos Santos, Pedro Augusto Laurindo Igreja Marrafa, João Gomes de Oliveira Neto, Carlos José de Lima and Adriana Barrinha Fernandes
J. Funct. Biomater. 2026, 17(7), 352; https://doi.org/10.3390/jfb17070352 - 20 Jul 2026
Viewed by 487
Abstract
This study aimed to verify the morphology, biochemical composition, and thermal characterization of hydrated human amniotic membrane (HAM) processed in an ozonated water hydrodynamic system. This is an in vitro experimental study in which HAM samples were divided into two groups: in natura [...] Read more.
This study aimed to verify the morphology, biochemical composition, and thermal characterization of hydrated human amniotic membrane (HAM) processed in an ozonated water hydrodynamic system. This is an in vitro experimental study in which HAM samples were divided into two groups: in natura (IN) and ozonated (O3). Analyses were performed using histology, Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA/DTG), and differential scanning calorimetry (DSC/dDSC). Ozonation for 40 min preserved the biochemical integrity of HAM, maintaining the characteristic vibrational bands of Amides I, II, and III. Histological analysis showed morphological changes in epithelial cells, with partial removal in some regions, while the basement membrane and the scaffold remained preserved. Thermal analysis revealed that the in natura sample presented a bimodal dehydration profile, with a first event occurring between 60 and 65 °C associated with the evaporation of free or weakly bound water, and a second event peaking around 80 °C related to the removal of structural water. In contrast, the ozonated HAM exhibited a unimodal profile, with the mass loss peak shifted to approximately 70 °C. These findings were corroborated by DSC analysis, which showed a reduction in denaturation temperature from approximately 85 °C in the in natura sample to around 75 °C in the ozonated sample. The dDSC analysis confirmed the transition from a bimodal to a unimodal behavior after treatment, indicating a reduced energy barrier for protein denaturation and lower thermal stability of the collagen matrix. These results suggest that ozonation promotes alterations in the epithelial layer, which may favor the loss of both free and bound water. It is concluded that processing with ozonated water induces structural modifications, especially in the epithelial layer, and reduces the thermal stability of hydrated HAM without significantly altering the biochemical signature of collagen. This approach shows potential as an alternative method for membrane processing; however, functional evaluations are required to confirm its clinical applicability. Full article
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