Multi-component Hydrogels for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 4832

Special Issue Editors


E-Mail Website
Guest Editor
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA
Interests: peptide hydrogels; biomaterials; immuno-materials

E-Mail Website
Guest Editor
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA
Interests: hydrogel; tissue engineering

Special Issue Information

Dear Colleagues,

Biomaterials is a field that combines medicine, biology, physics, chemistry, engineering and materials science to design diverse materials capable of interacting with various biological systems. Multi-component materials have gained interest in recent literature, as these are particularly attractive over single-component materials due to the fact that combinative functions can be generated from various components into one single material. Multi-component materials can achieve a range of various properties including novel morphologies, changes in mechanical properties and multi-functionality, resembling natural systems more accurately and overcoming the limitations of single-component systems.

This Special Issue will focus on the combination of various types of biomaterials including polymers, peptide-based hydrogels, nanoclays, stimuli-responsive materials, self-healing materials, shear-thinning materials, cross-linkable materials, “smart” materials and interpenetrating networks for various biomedical applications. Biomedical applications include, but are not limited to, multi-component biomaterials for tissue engineering and wound healing applications, 3D bioprinting, in vitro disease modeling, antimicrobial applications, wearable electronics, drug delivery and as immune-instructive materials or for immunomodulation.

Dr. Natashya Falcone
Dr. Menekse Ermis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multi-component hydrogels
  • biomaterials
  • tissue engineering
  • immuno-materials
  • wound healing
  • drug delivery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 8013 KiB  
Article
Peptide Hydrogel for Sustained Release of Recombinant Human Bone Morphogenetic Protein-2 In Vitro
by Dalin Wang, Guangyan Qi, Mingcai Zhang, Brandon Carlson, Matthew Gernon, Douglas Burton, Xiuzhi Susan Sun and Jinxi Wang
J. Funct. Biomater. 2024, 15(12), 369; https://doi.org/10.3390/jfb15120369 - 6 Dec 2024
Viewed by 4251
Abstract
This study aimed to investigate the impact of varying the formulation of a specific peptide hydrogel (PepGel) on the release kinetics of rhBMP-2 in vitro. Three PepGel formulations were assessed: (1) 50% v/v (peptides volume/total volume) PepGel, where synthetic peptides were [...] Read more.
This study aimed to investigate the impact of varying the formulation of a specific peptide hydrogel (PepGel) on the release kinetics of rhBMP-2 in vitro. Three PepGel formulations were assessed: (1) 50% v/v (peptides volume/total volume) PepGel, where synthetic peptides were mixed with crosslinking reagents and rhBMP-2 solution; (2) 67% v/v PepGel; (3) 80% v/v PepGel. Each sample was loaded with 12 µg of rhBMP-2 and incubated in PBS. Released rhBMP-2 was quantified by ELISA at 1 h, 6 h, and 1, 2, 4, 7, 10, 14, and 21 days. To explore how PepGel formulations influence rhBMP-2 release, the gel porosities, swelling ratios, and mechanical properties of the three PepGel formulations were quantitatively analyzed. The results showed that rhBMP-2 encapsulated with 50% v/v PepGel exhibited a sustained release over the 21-day experiment, while the 67% and 80% v/v PepGels demonstrated significantly lower rhBMP-2 release rates compared to the 50% formulation after day 7. Higher histological porosity of PepGel was significantly correlated with increased rhBMP-2 release rates. Conversely, the swelling ratio and elastic modulus of the 50% v/v PepGel were significantly lower than that of the 67% and 80% v/v formulations. In conclusion, this study indicates that varying the formulation of crosslinked PepGel can control rhBMP-2 release rates in vitro by modulating gel porosity, swelling ratio, and mechanical properties. Encapsulation with 50% v/v PepGel offers a sustained rhBMP-2 release pattern in vitro; if replicated in vivo, this could mitigate the adverse effects associated with burst release of rhBMP-2 in clinical applications. Full article
(This article belongs to the Special Issue Multi-component Hydrogels for Biomedical Applications)
Show Figures

Figure 1

Back to TopTop