Cardiac Amyloidosis and Heart Failure: Clinical Pathophysiology, Diagnosis, and Therapeutic Strategies

Dear Colleagues,

Cardiac amyloidosis, once considered a rare and underdiagnosed cause of heart failure, is now recognized as an increasingly prevalent condition, particularly among elderly patients and those with heart failure with preserved ejection fraction. Advances in imaging, biomarkers, and non-invasive diagnostic techniques have significantly improved early recognition, while the therapeutic landscape has evolved rapidly with the introduction of disease-modifying agents. This Special Issue will provide a comprehensive overview of the clinical pathophysiological mechanisms linking amyloid deposition to cardiac dysfunction, highlight the latest developments in diagnostic tools—including cardiac imaging and novel biomarkers—and explore emerging and established therapeutic strategies. By bringing together original research, state-of-the-art reviews, and expert opinions, this Special Issue will enhance our understanding of the complex interplay between cardiac amyloidosis and heart failure.

We hope that this Special Issue will serve as a valuable resource for clinicians, researchers, and all professionals engaged in the care and study of patients with cardiac amyloidosis.

Dr. Ilaria Dentamaro
Dr. Laura Fusini
Guest Editors

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