Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Disease Progression of Retinopathy in Type 2 Diabetes
share announcement

Disease Progression of Retinopathy in Type 2 Diabetes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (2 December 2021) | Viewed by 6069

Special Issue Editor

Prof. Dr. Jose Cunha-Vaz

E-Mail
Guest Editor
1. AIBILI, Edifício Prof. Doutor José Cunha-Vaz, Azinhaga de Santa Comba – Celas, 3000-548 Coimbra, Portugal
2. CHUC – Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3004-561 Coimbra, Portugal
Interests: diabetic retinopathy; biomarkers; image analysis; microvascular function and disease; blood-retinal barrier; multimodal imaging

Special Issue Information

Dear Colleagues, 

Diabetic retinopathy (DR) is a frequent complication of diabetes and through its sight-threatening complications, i. e., macular edema and proliferative retinopathy, may lead to blindness.

The availability of treatment only for the late stages of the disease and its rate of success make it urgent to understand the early alterations of DR and their progression in order to develop timely treatments before vision loss.

A fundamental characteristic of DR is that its course is not linear and the progression of DR varies in different individuals with the development of sight-threatening complications occurring only in a few patients. The activity of disease and its progression varies from patient to patient. It is clear now that only a subset of patients with diabetes who develop retinal changes is expected to progress to advanced retinopathy stages and is at risk of losing functional vision during their lifetime. This Special Issue is aimed at the importance of the identification of biomarkers of progression of DR to vision-threatening complications. In addition, this Special Issue, will emphasize the importance of retinal imaging in the diagnosis and characterization of progression of diabetic retinopathy. 

Prof. Dr. Jose Cunha-Vaz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes type 2
  • retina
  • diabetic retinopathy
  • retinal neurodegeneration
  • retina edema
  • retinal ischemia
  • retinal imaging
  • optical coherence tomography
  • OCTA – optical coherence tomography
  • biomarkers

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research

4 pages, 187 KiB  
Editorial
A Central Role for Ischemia and OCTA Metrics to Follow DR Progression
by José Cunha-Vaz
J. Clin. Med. 2021, 10(9), 1821; https://doi.org/10.3390/jcm10091821 - 22 Apr 2021
Cited by 4 | Viewed by 1415
Abstract
Diabetic retinopathy (DR) is a frequent complication of diabetes and through its vision-threatening complications, i [...] Full article
(This article belongs to the Special Issue Disease Progression of Retinopathy in Type 2 Diabetes)

Research

Jump to: Editorial

9 pages, 833 KiB  
Article
Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
by Inês P. Marques, Sophie Kubach, Torcato Santos, Luís Mendes, Maria H. Madeira, Luis de Sisternes, Diana Tavares, Ana Rita Santos, Warren Lewis, Conceição Lobo, Mary K. Durbin and José Cunha-Vaz
J. Clin. Med. 2021, 10(11), 2296; https://doi.org/10.3390/jcm10112296 - 25 May 2021
Cited by 13 | Viewed by 1933
Abstract
To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, [...] Read more.
To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression. Full article
(This article belongs to the Special Issue Disease Progression of Retinopathy in Type 2 Diabetes)
►▼ Show Figures

Figure 1

8 pages, 252 KiB  
Article
Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study
by Ana Rita Santos, Luis Mendes, Maria Helena Madeira, Ines P. Marques, Diana Tavares, João Figueira, Conceição Lobo and José Cunha-Vaz
J. Clin. Med. 2021, 10(10), 2142; https://doi.org/10.3390/jcm10102142 - 15 May 2021
Cited by 14 | Viewed by 2096
Abstract
Background: Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression [...] Read more.
Background: Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications. Methods: 212 individuals with type 2 diabetes (T2D; ETDRS grades 20 and 35) were evaluated annually in a 5-year prospective, longitudinal study, by color fundus photography and optical coherence tomography. Endpoints were diabetic macular edema (DME) or proliferative retinopathy (PDR). MAT analysis included determination of MA formation and disappearance rates, automatically assessed using the RetMarkerDR®. Retinopathy severity progression was evaluated using step increases in ETDRS severity levels. Results: Of the 212 individuals, 172 completed the 5-year follow-up study or developed an endpoint (n = 27). MAT calculated at 1 year showed a significant difference between groups of endpoint developments (p = 0.018), particularly MA disappearance rate (p = 0.007). MAT also showed a significant difference between eyes with different ETDRS severity progression in the 5-year period (p = 0.035). Conclusions: MAT is an indicator of the development of DME and/or PDR as well as of DR severity progression in T2D individuals with mild retinopathy. Full article
(This article belongs to the Special Issue Disease Progression of Retinopathy in Type 2 Diabetes)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop