Liquid Biopsies in Lung Cancer
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 27622
Special Issue Editors
2. Institute for Research and Inovation in Health (i3S), University of Porto, 4099-002 Porto, Portugal
Interests: evidence-based medicine; phytochemistry; phytopharmacology; drug discovery; natural products biochemistry; bioactive molecules; functional foods; nutraceuticals; fungal and bacterial infections; resistance to antimicrobials
Special Issues, Collections and Topics in MDPI journals
2. Faculty of Medicine, University of Porto, Porto, Portugal
Interests: thoracic tumors; oncology; tumors biology; interventional pulmonology; cancer diagnostics; cancer immunology
Special Issue Information
Dear Colleagues,
Tumor biopsies are considered the standard for anatomopathological and molecular diagnosis. Besides being obtained by invasive methods, they only represent a point in time and a point in space of all tumor biology and evolution. For several years, clinicians and researchers dedicated to cancer have pursued the idea of non-invasive diagnosis, through the study of peripheral blood and other bodily fluids. Indeed, tumors release parts of themselves into the circulation (e.g. free nucleic acids, tumor cells, exosomes, among others), and these elements can be extracted and analyzed. Considering that lung cancer is one of the leading causes of cancer mortality, it is of utmost interest to ensure constant progress in cancer biology comprehension. In fact, the substantial knowledge reached in lung cancer biology has led to several advances in targeted therapies and immunotherapy, while the recent achievements in sequencing technologies have made this ambition a reality. Therefore, the development of the non-invasive evaluation of tumor-releasing or tumor-associated elements, called liquid biopsy, may offer a unique opportunity to help with lung cancer screening, to detect minimal residual disease and early relapses, to detect specific mutations, to monitor the development of treatment response and resistance mechanisms, as well as to assess immunotherapy-related parameters. Currently, liquid biopsy is conceived as an inescapable reality, with special emphasis on lung cancer management. However, their inclusion in both diagnostic and therapeutic decision-making processes raises many questions. Thus, and in a broad sense, all of the questions and advances that intersect both the present and future of liquid biopsies in lung cancer management are welcome in this Special Issue. Original articles, comprehensive and critical reviews, case reports and even letters are of utmost interest, given the expansive interest of this area.
Prof. Dr. Natália Martins
Dr. Gabriela Fernandes
Dr. Vanessa Santos
Guest Editors
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Keywords
- Liquid biopsies
- Lung cancer
- Cell-free DNA
- Circulating tumor DNA
- Next-generation sequencing
- Resistance mechanisms
- Predictive and prognostic biomarkers
- Genetic mutations
- Targeted therapy
- Biological monitoring
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