Antimicrobial Properties of Plants-Derived Natural Products

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5535

Special Issue Editor


E-Mail Website
Guest Editor
1. Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
2. TOXRUN—Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal
Interests: evidence-based medicine; phytochemistry; phytopharmacology; drug discovery; bioactive molecules; functional foods; nutraceuticals; oxidative stress; inflammation; infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medicinal plants have long been recognized for their multiple potentialities. Across a broad range of bioactive compounds, a multitude of studies have been performed, from basic to increasingly complex ones, to deepen knowledge on the pharmacological potential of both plants extracts and their isolated constituents. Among the main concerns in terms of health, infectious diseases have proved to be a significant challenge, motivated by the increasing rates of acquired resistance to currently available drugs, but also by their adverse effects and associated toxicity, which have been exacerbated due to the increasing use of higher doses, and even their combination. As a result of this current scenario, more and more studies have focused on discovering the therapeutic potential of plants and deepening their mechanism of action, with a view to providing new drugs, more effective and safer than those currently available. From a biochemical point of view, among the various compounds present and currently identified and chemically characterized, several still remain unknown, while to those already discovered, the screening studies were performed to address their biological activity have been promising, although to some phytochemicals metabolization needs to take place so that they become available and biologically active, the direct applicability of such findings in in vivo experiments being questionable. Lastly, and with a view of translating in vivo findings to clinical scenarios, intensive translational research has been conducted to date, not only to validate the main findings obtained by in vitro experiments, but also to project the upcoming use of such promising molecules with outstanding antimicrobial activity for further chemical synthesis and assessment of their pharmacological activity in clinical trials. Taking this in mind, the current Special Issue encourages the submission of in vitro, in vivo, and clinical studies addressing the antimicrobial effects and molecular mechanisms of plant-derived bioactive compounds, including chemical characterization and quantification, determination of mechanisms of action, target identification, structure–activity relationships, and therapeutic applications. Original articles, review articles, critical reviews, mini-reviews, comments, perspectives, and even short communications are particularly welcome. We look forward to receiving your contributions and welcome you to join us in this effort.

Prof. Dr. Natália Cruz-Martins
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Infectious diseases
  • inflammation
  • bioactive molecules
  • phytochemistry
  • drug discovery
  • antimicrobials

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 1222 KiB  
Article
The Effect of Fruit and Berry Pomaces on the Growth Dynamics of Microorganisms and Sensory Properties of Marinated Rainbow Trout
by Mati Roasto, Mihkel Mäesaar, Tõnu Püssa, Dea Anton, Reelika Rätsep, Terje Elias, Salli Jortikka, Merilin Pärna, Karmen Kapp, Marek Tepper, Kristi Kerner and Kadrin Meremäe
Microorganisms 2023, 11(12), 2960; https://doi.org/10.3390/microorganisms11122960 - 11 Dec 2023
Cited by 2 | Viewed by 1273
Abstract
Plant pomaces in suitable forms (powders, extracts) can be used in foods of animal origin to increase the nutritional value and safety of these foods. In the present study, water extracts of apple, black currant, rhubarb and tomato pomaces were used in fish [...] Read more.
Plant pomaces in suitable forms (powders, extracts) can be used in foods of animal origin to increase the nutritional value and safety of these foods. In the present study, water extracts of apple, black currant, rhubarb and tomato pomaces were used in fish marinade solutions to evaluate their effect on the growth dynamics of microorganisms and the growth potential of Listeria monocytogenes by challenge testing. The results showed that mesophilic aerobic microorganisms, Pseudomonas spp., yeasts and moulds remained at acceptable levels throughout the predetermined storage period. The challenge test results showed that the overall growth potential of L. monocytogenes in all marinated rainbow trout samples remained at ≤0.5 log10 cfu/g during the study period, and none of the marinated fish samples supported the growth of L. monocytogenes. In addition, the effect of fruit and berry pomaces on the sensory properties of marinated rainbow trout samples was evaluated. The results revealed that it is possible to effectively use fruit and berry pomaces in marinated fish products, ensuring food safety, high microbiological quality, acceptable sensory characteristics and a sufficiently long shelf life of the products. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Plants-Derived Natural Products)
Show Figures

Figure 1

18 pages, 1061 KiB  
Article
Mediterranean Plants with Antimicrobial Activity against Staphylococcus aureus, a Meta-Analysis for Green Veterinary Pharmacology Applications
by Francesca Oppedisano, Rosario De Fazio, Enrico Gugliandolo, Rosalia Crupi, Ernesto Palma, Sayed Haidar Abbas Raza, Bruno Tilocca, Carmine Merola, Cristian Piras and Domenico Britti
Microorganisms 2023, 11(9), 2264; https://doi.org/10.3390/microorganisms11092264 - 9 Sep 2023
Cited by 2 | Viewed by 1295
Abstract
Antimicrobial resistance (AMR) has emerged as a global health crisis, necessitating the search for innovative strategies to combat infectious diseases. The unique biodiversity of Italian flora offers a treasure trove of plant species and their associated phytochemicals, which hold immense potential as a [...] Read more.
Antimicrobial resistance (AMR) has emerged as a global health crisis, necessitating the search for innovative strategies to combat infectious diseases. The unique biodiversity of Italian flora offers a treasure trove of plant species and their associated phytochemicals, which hold immense potential as a solution to address AMR. By investigating the antimicrobial properties of Italian flora and their phytochemical constituents, this study aims to shed light on the potential of phyto-complexes as a valuable resource for developing novel or supportive antimicrobial agents useful for animal production. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Plants-Derived Natural Products)
Show Figures

Figure 1

12 pages, 2397 KiB  
Article
Antiherpetic Activity of Taurisolo®, a Grape Pomace Polyphenolic Extract
by Carla Zannella, Annalisa Chianese, Giuseppe Annunziata, Annalisa Ambrosino, Anna De Filippis, Gian Carlo Tenore, Ettore Novellino, Mariano Stornaiuolo and Massimiliano Galdiero
Microorganisms 2023, 11(5), 1346; https://doi.org/10.3390/microorganisms11051346 - 20 May 2023
Cited by 3 | Viewed by 1778
Abstract
Herpes simplex virus (HSV) is widespread in the population, causing oral or genital ulcers and, rarely, severe complications such as encephalitis, keratitis, and neonatal herpes. Current available anti-HSV drugs are acyclovir and its derivatives, although long-term therapy with these agents can lead to [...] Read more.
Herpes simplex virus (HSV) is widespread in the population, causing oral or genital ulcers and, rarely, severe complications such as encephalitis, keratitis, and neonatal herpes. Current available anti-HSV drugs are acyclovir and its derivatives, although long-term therapy with these agents can lead to drug resistance. Thus, the discovery of novel antiherpetic compounds merits additional studies. In recent decades, much scientific effort has been invested in the discovery of new synthetic or natural compounds with promising antiviral properties. In our study, we tested the antiviral potential of a novel polyphenol-based nutraceutical formulation (named Taurisolo®) consisting of a water polyphenol extract of grape pomace. The evaluation of the antiviral activity was carried out by using HSV-1 and HSV-2 in plaque assay experiments to understand the mechanism of action of the extract. Results were confirmed by real-time PCR, transmission electron microscope (TEM), and fluorescence microscope. Taurisolo® was able to block the viral infection by acting on cells when added together with the virus and also when the virus was pretreated with the extract, demonstrating an inhibitory activity directed to the early phases of HSV-1 and HSV-2 infection. Altogether, these data evidence for the first time the potential use of Taurisolo® as a topical formulation for both preventing and healing herpes lesions. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Plants-Derived Natural Products)
Show Figures

Figure 1

Back to TopTop