Prognostic Factors and Outcomes of Acute Leukemias in the Era of Novel Therapies
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: closed (10 December 2020) | Viewed by 192
Special Issue Editor
Special Issue Information
Dear Colleagues,
The development of high-throughput sequencing technologies and the relentless pursuit of quality translational and clinical research has allowed us to understand the process of leukemogenesis driven by recurrent mutations and design therapies that target these mutations. As a result, the landscape of standard therapy for acute leukemias has remarkably changed, and only within the last few years, several new agents were approved in acute leukemias. Today, clinicians make therapy decisions not only based on patient-related factors but also on specific molecular and cytogenetic features. For example, in acute myeloid leukemia, underlying driver mutations have become one of the major determinants in therapy decisions. Patients with fms-like tyrosine kinase 3 or isocitrate dehydrogenase mutations are being treated with agents targeting these mutations. Similarly, detection of the Philadelphia chromosome and positivity of cell surface antigens, such as CD19, CD20, and CD22, have become essential parameters in therapy decisions for patients with acute lymphoblastic leukemia. However, despite all these achievements with novel chemotherapeutics, patients with acute leukemia still relapse. Hence, understanding the predictors of response and mechanisms of relapse has become crucial to developing superior treatment strategies. The present Special Issue aims to expand the knowledge on pathological and clinical characteristics, resistance mechanisms, and outcomes of patients with acute leukemia following treatment with novel agents.
Dr. Musa Yilmaz
Guest Editor
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Keywords
- Early response assessment in acute leukemias
- Role of minimal residual disease (flow cytometry, polymerase chain reaction)
- Impact of cytogenetic, genomic and other prognostic factors
- Novel therapeutic strategies in acute lymphoblastic leukemia
- Novel therapeutic strategies in acute myeloid leukemia
- Prognosis and treatment of older adults with acute leukemias
- Toxicities of recently approved novel chemotherapeutics
- Stem cell transplantation in acute leukemias
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