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Latest Advances and Prospects in Movement Disorders
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Latest Advances and Prospects in Movement Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (10 April 2025) | Viewed by 1588

Special Issue Editor

Dr. Julían Benito-Léon

E-Mail Website
Guest Editor
1. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain
2. Department of Neurology, University Hospital 12 de Octubre, 28041 Madrid, Spain
3. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBER-NED), 28029 Madrid, Spain
4. Department of Medicine, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
Interests: Parkinson's disease; dystonia; essential tremor; deep brain stimulation; movement disorder pathophysiology; therapeutic innovations; motor neuron disorders; neuroimaging; neuropharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to serve as the Guest Editor for this Special Issue titled “Latest Advances and Prospects in Movement Disorders”. This edition aims to highlight groundbreaking research and emerging therapies in the field of movement disorders. With the prevalence of conditions such as Parkinson’s disease, dystonia, and tremor continuing to rise, there is a critical need for innovative diagnostic and therapeutic strategies. This Special Issue will encompass a wide range of topics including the epidemiology, pathophysiology, clinical manifestations, and novel treatment approaches for these disorders. We invite researchers and clinicians to contribute their findings and insights, fostering a deeper understanding and paving the way for future advancements in this dynamic field.

Dr. Julían Benito-Léon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson's disease
  • dystonia
  • essential tremor
  • deep brain stimulation
  • movement disorder pathophysiology
  • therapeutic innovations
  • motor neuron disorders
  • neuroimaging
  • neuropharmacology

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Published Papers (2 papers)

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18 pages, 914 KiB  
Article
Twenty-Three-Year Mortality in Parkinson’s Disease: A Population-Based Prospective Study (NEDICES)
by Carla María Benito-Rodríguez, Félix Bermejo-Pareja, Ángel Berbel, José Lapeña-Motilva and Julián Benito-León
J. Clin. Med. 2025, 14(2), 498; https://doi.org/10.3390/jcm14020498 - 14 Jan 2025
Viewed by 766
Abstract
Background: Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a [...] Read more.
Background: Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population. Methods: In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994–1995) and follow-up (1997–1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables. Results: Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31–2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24–3.89). Early-onset PD (<65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22–3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%, p < 0.001). Conclusions: PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes. Full article
(This article belongs to the Special Issue Latest Advances and Prospects in Movement Disorders)
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Review

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26 pages, 325 KiB  
Review
The Association Between Essential Tremor and Parkinson’s Disease: A Systematic Review of Clinical and Epidemiological Studies
by Elan D. Louis
J. Clin. Med. 2025, 14(8), 2637; https://doi.org/10.3390/jcm14082637 - 11 Apr 2025
Viewed by 458
Abstract
Background/Objectives: The objective is to systematically review evidence from clinical and epidemiological studies for or against an association between essential tremor (ET) and Parkinson’s disease (PD). Methods: A literature search in PubMed (February 2025) used several combinations of keywords. Thirty-three studies (1960–2023) were [...] Read more.
Background/Objectives: The objective is to systematically review evidence from clinical and epidemiological studies for or against an association between essential tremor (ET) and Parkinson’s disease (PD). Methods: A literature search in PubMed (February 2025) used several combinations of keywords. Thirty-three studies (1960–2023) were identified. Results: The best available data are derived from a population-based study in Spain, followed by a cohort study in the US. Each of these prospective studies provided evidence that ET is a risk factor for PD, with elevated risks of ~4–5. In cross-sectional studies, in which the proportion of PD cases with ET has been reported, the weight of evidence demonstrates an association between ET and PD. In 16 (88.9%) of 18 family studies, the odds ratios or hazards ratios are elevated—i.e., there is considerable evidence that ET is over-represented in PD families and, conversely, PD is over-represented in ET families. Conclusions: A comprehensive review of published data strongly supports an association between ET and PD and, more specifically, provides evidence that ET is a risk factor for PD. Seven of nine review articles (and six of seven non-commissioned review articles) have concluded that there is an association between these two degenerative diseases. The “controversy” that surrounds the ET–PD association is more of a repeated myth than a well-informed reality. As a field, it would be more productive to finally move beyond uniformed debate and focus our efforts on attempts to elucidate the basis for the association to which the data are repeatedly pointing. Full article
(This article belongs to the Special Issue Latest Advances and Prospects in Movement Disorders)
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