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Clinical Research on Diabetes and Its Complications
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Clinical Research on Diabetes and Its Complications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 8269

Special Issue Editor

Dr. Fernando Gómez-Peralta

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Guest Editor
Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain
Interests: epidemiology of diabetes and complications; clinical therapeutics of diabetes; continuous glucose monitoring; diabetes telemedicine; diabetes smart pens/caps; diabetes drug/insulin development/clinical trials; hypoglycaemia in diabetes; sleep disorders and diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I have the honour of being the Guest Editor of Part II of Special Issue "Clinical Research on Type 2 Diabetes and Its Complications": https://www.mdpi.com/journal/jcm/special_issues/Type_2_Diabetes_Complications.

This Special Issue will bring together papers focused on clinically relevant research on diabetes and its complications, ideally offering a sound overview of the most interesting topics in the field. The Issue should be an attractive condensed reading for physicians interested in a general view of diabetes, including primary care, internal medicine, and geriatric medicine.

Manuscripts describing clinical research on diabetes, including original research, reviews, or communications, are welcome for submission. Research and data from a global and multiethnic source are particularly appreciated. The roles of new technologies in the detection, management, and prediction of diabetic complications are also of interest. We aim to present an updated view on the current incidence, prevalence, and disease burden caused by diabetes complications.

Dr. Fernando Gómez-Peralta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 2 diabetes
  • diabetes complications
  • diabetes clinical research
  • diabetes treatment
  • continuous glucose monitoring
  • prevalence
  • incidence

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Related Special Issue

Published Papers (4 papers)

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Research

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14 pages, 292 KiB  
Article
Performance of Primary Care Physicians in the Management of Glycemia, Lipids, and Blood Pressure among People with Type 2 Diabetes: A Cross-Sectional Study
by Bogdan Vlacho, Berta Fernandez-Camins, Albert Canudas-Ventura, Andrés Rodríguez, Àngels Mollo, Francesc Xavier Cos Claramunt, Maria Antentas, Dídac Mauricio and Josep Franch-Nadal
J. Clin. Med. 2024, 13(6), 1544; https://doi.org/10.3390/jcm13061544 - 7 Mar 2024
Cited by 4 | Viewed by 2205
Abstract
Background: Our study aimed to evaluate the performance of primary healthcare physicians (PCPs) in managing glycemia, lipids, and blood pressure in people with type 2 diabetes mellitus (T2DM) in Catalonia, Spain. Methods: We included 3267 PCPs with 367,132 T2DM subjects in a cross-sectional [...] Read more.
Background: Our study aimed to evaluate the performance of primary healthcare physicians (PCPs) in managing glycemia, lipids, and blood pressure in people with type 2 diabetes mellitus (T2DM) in Catalonia, Spain. Methods: We included 3267 PCPs with 367,132 T2DM subjects in a cross-sectional analysis of the SIDIAP (Sistema d’Informació per al Desenvolupament de la Investigació en Atenció Primària) database for the year 2017. Results: 63.1% of PCPs were female, with an average practice size of 1512 subjects. T2DM individuals had a mean (standard deviation) age of 70 (±12.2) years old, a mean body mass index (BMI) of 30.2 (±5.21) kg/m2, and a median diabetes duration of 8.8 years. Overall, 42.6% of subjects achieved target glycemic control (glycated hemoglobin < 7%). Notably, 59.2% maintained blood pressure < 140/90 mmHg during the 12-month study period. The multivariable analysis identified positive associations between glycemic control and female PCPs, practice sizes (1000–1500 people), a higher proportion of patients aged ≥ 65 years, and rural practices. Combined glycemic, lipid, and blood pressure target attainment was associated with medium-sized practices and those with a higher proportion of patients aged ≥ 65 years. Conclusions: Practice size, patient age distribution, and rurality are factors associated with the performance of PCPs in the control of glycemia, lipids, and blood pressure in T2DM subjects in primary health care centers in our region. Full article
(This article belongs to the Special Issue Clinical Research on Diabetes and Its Complications)
11 pages, 1377 KiB  
Article
Causes of In-Hospital Death and Pharmaceutical Associations with Age of Death during a 10-Year Period (2011–2020) in Individuals with and without Diabetes at a Japanese Community General Hospital
by Minae Hosoki, Taiki Hori, Yousuke Kaneko, Kensuke Mori, Saya Yasui, Seijiro Tsuji, Hiroki Yamagami, Saki Kawata, Tomoyo Hara, Shiho Masuda, Yukari Mitsui, Kiyoe Kurahashi, Takeshi Harada, Shingen Nakamura, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa and Ken-ichi Aihara
J. Clin. Med. 2024, 13(5), 1283; https://doi.org/10.3390/jcm13051283 - 24 Feb 2024
Viewed by 1502
Abstract
Since diabetes and its complications have been thought to exaggerate cardiorenal disease, resulting in a short lifespan, we investigated causes of death and lifespans in individuals with and without diabetes at a Japanese community general hospital during the period from 2011 to 2020. [...] Read more.
Since diabetes and its complications have been thought to exaggerate cardiorenal disease, resulting in a short lifespan, we investigated causes of death and lifespans in individuals with and without diabetes at a Japanese community general hospital during the period from 2011 to 2020. Causes of death and age of death in individuals with and those without diabetes were compared, and associations between medications used and age of death were statistically analyzed. A total of 2326 deaths were recorded during the 10-year period. There was no significant difference between the mean ages of death in individuals with and those without diabetes. Diabetic individuals had higher rates of hepato-pancreatic cancer and cardio-renal failure as causes of death. The prescription rates of antihypertensives, antiplatelets, and statins in diabetic individuals were larger than those in non-diabetic individuals. Furthermore, the use of sulfonyl urea or glinides and insulin was independently and inversely associated with the age of death. In conclusion, individuals with diabetes were treated with comprehensive pharmaceutical interventions and had life spans comparable to those of individuals without diabetes. This study’s discovery of an inverse relationship between the use of insulin secretagogues or insulin and the age of death suggests that the prevention of life-threatening hypoglycemia is crucial for individuals with diabetes. Full article
(This article belongs to the Special Issue Clinical Research on Diabetes and Its Complications)
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11 pages, 1152 KiB  
Article
Feasibility of a Type 2 Diabetes Prevention Program at Nationwide Level in General Practice: A Pilot Study in Italy
by Rosalba La Grotta, Valeria Pellegrini, Francesco Prattichizzo, Oriana Amata, Lorenzo Panella, Antonio Frizziero, Marco Visconti, Gabriella Averame, Pier Claudio Brasesco, Ilaria Calabrese, Olga Vaccaro and Antonio Ceriello
J. Clin. Med. 2024, 13(4), 1127; https://doi.org/10.3390/jcm13041127 - 16 Feb 2024
Viewed by 1620
Abstract
Background: Lifestyle interventions halt the progression of prediabetes to frank type 2 diabetes (T2D). However, the feasibility of a diabetes prevention program promoting tailored interventions on a national scale and conducted by primary care physicians is unclear. Methods: General practitioners located in ten [...] Read more.
Background: Lifestyle interventions halt the progression of prediabetes to frank type 2 diabetes (T2D). However, the feasibility of a diabetes prevention program promoting tailored interventions on a national scale and conducted by primary care physicians is unclear. Methods: General practitioners located in ten different regions throughout Italy enrolled random subjects without known metabolic diseases to identify individuals with prediabetes and prescribe them an intervention based on physical activity. Using a simple stepwise approach, people referring to their primary care physician for any reason were screened for their diabetes risk with a web-based app of the Findrisc questionnaire. Those at risk for T2D, i.e., with a Findrisc score >9, were invited to come back after overnight fasting to measure fasting glycaemia (FG). Those with 100 ≤ FG < 126 mg/dL were considered as people with prediabetes and compiled the Physical Activity Readiness Questionnaire (PAR-Q) to then receive a personalised prescription of physical activity. Results: Overall, 5928 people were enrolled and compiled the questionnaire. Of these, 2895 (48.8%) were at risk for T2D. Among these, FG was measured in 2168 subjects (participation rate 75%). The numbers of individuals with undetected prediabetes and T2D according to FG were 755 and 79 (34.8% and 3.6% of those assessing FG), respectively. Of the 755 subjects in the prediabetes range, 739 compiled the PAR-Q and started a personalised program of physical activity (participation rate 97%). Physicians involved in the study reported a mean of 6 min to perform the screening. Conclusions: Overall, these data suggest the feasibility of a national diabetes prevention program developed by general practitioners using a simple stepwise approach starting from a web app to intercept individuals with prediabetes. Full article
(This article belongs to the Special Issue Clinical Research on Diabetes and Its Complications)
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Review

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11 pages, 1872 KiB  
Review
Diabetes Management Based on the Phenotype and Stage of the Disease: An Expert Proposal from the AGORA Diabetes Collaborative Group
by Fernando Gómez-Peralta, Pedro J. Pinés-Corrales, Estefanía Santos, Martín Cuesta, Olga González-Albarrán, Sharona Azriel and on behalf the AGORA Diabetes Collaborative Group
J. Clin. Med. 2024, 13(16), 4839; https://doi.org/10.3390/jcm13164839 - 16 Aug 2024
Cited by 2 | Viewed by 2452
Abstract
Diabetes is a complex and rapidly growing disease with heterogeneous clinical presentations. Recent advances in molecular and genetic technologies have led to the identification of various subtypes of diabetes. These advancements offer the potential for a more precise, individualized approach to treatment, known [...] Read more.
Diabetes is a complex and rapidly growing disease with heterogeneous clinical presentations. Recent advances in molecular and genetic technologies have led to the identification of various subtypes of diabetes. These advancements offer the potential for a more precise, individualized approach to treatment, known as precision medicine. Recognizing high-risk phenotypes and intervening early and intensively is crucial. A staging system for type 1 diabetes has been proposed and accepted globally. In this article, we will explore the different methods for categorizing and classifying type 2 diabetes (T2D) based on clinical characteristics, progression patterns, risk of complications, and the use of molecular techniques for patient grouping. We, as a team of experts, will also present an easy-to-follow treatment plan and guidance for non-specialists, particularly primary care physicians, that integrates the classification and staging of diabetes. This will help ensure that the most suitable therapy is applied to the different types of T2D at each stage of the disease’s progression. Full article
(This article belongs to the Special Issue Clinical Research on Diabetes and Its Complications)
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