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Arthritis: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 796

Special Issue Editors


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Guest Editor
1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS2 9JT, UK
2. Leeds Biomedical Research Centre, National Institute for Health Research, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK
Interests: rheumatoid arthritis; psoriatic arthritis; imaging; ultrasound; DMARDs; differential diagnosis

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Guest Editor
1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS2 9JT, UK
2. Leeds Biomedical Research Centre, National Institute for Health Research, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK
Interests: preclinical and early rheumatoid arthritis (RA); RA prevention; ultrasound and MRI; palindromic rheumatism; mucosal autoimmunity and RA; clinical trials in RA
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue on inflammatory arthritis. Inflammatory arthritis, including conditions like rheumatoid arthritis (RA) and psoriatic arthritis (PsA), affects millions of people worldwide, causing pain and a reduced quality of life.

Despite important advancements in arthritis research, significant challenges remain, particularly in the early diagnosis of these conditions and the development of personalized treatments tailored to individual patients. This Special Issue aims to address these issues by focusing on innovative diagnostic methods, such as advanced imaging techniques, and a deeper understanding of disease mechanisms. It will also explore cutting-edge treatments, including disease-modifying anti-rheumatic drugs (DMARDs), biologics, and targeted therapies.

A key goal of this Special Issue is to improve how healthcare professionals differentiate between similar types of arthritis, enabling quicker and more accurate diagnoses, and to better assess the extra-articular manifestations of these diseases.

By encouraging contributions from researchers across the globe, this Special Issue hopes to gather innovative ideas that can enhance arthritis care. Ultimately, the goal is to provide patients with faster diagnoses and more effective, tailored treatments, closing gaps in current medical approaches and improving overall outcomes for those living with inflammatory arthritis.

We look forward to your valuable contributions!

Dr. Andrea Di Matteo
Dr. Kulveer Mankia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rheumatoid arthritis
  • psoriatic arthritis
  • imaging
  • ultrasound
  • DMARDs
  • differential diagnosis
  • difficult to treat rheumatoid arthritis
  • prevention

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Published Papers (1 paper)

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8 pages, 4982 KiB  
Case Report
Cutaneous Nodules and Inflammatory Arthritis: Two Illustrative Cases of Rare Mimics of Rheumatoid Arthritis
by Reena Yaman, David J. DiCaudo, Olayemi Sokumbi, Michael M. Pham, Fawad Aslam, W. Leroy Griffing and Megan M. Sullivan
J. Clin. Med. 2025, 14(14), 4940; https://doi.org/10.3390/jcm14144940 - 12 Jul 2025
Viewed by 389
Abstract
Background: Rheumatoid arthritis is a relatively common rheumatic disease that can present with inflammatory arthritis and subcutaneous nodules. Multicentric reticulohistiocytosis and fibroblastic rheumatism are rarer entities that also present with these features. Methods: Two cases, one of each of fibroblastic rheumatism and multicentric [...] Read more.
Background: Rheumatoid arthritis is a relatively common rheumatic disease that can present with inflammatory arthritis and subcutaneous nodules. Multicentric reticulohistiocytosis and fibroblastic rheumatism are rarer entities that also present with these features. Methods: Two cases, one of each of fibroblastic rheumatism and multicentric reticulohistiocytosis, are described highlighting characteristic clinical, radiographic, and histologic findings. A narrative review of the literature on these rarer conditions, compared with rheumatoid arthritis, is provided with a focus on articular and cutaneous findings, available information on disease presentations, and key contrasting features that can aid in diagnosis. Results: Radiographic erosion distribution and joint space narrowing, clinical nodule distribution and characteristics, and nodule histology can differ between these diseases. Conclusions: Multicentric reticulohistiocytosis and fibroblastic rheumatism should be considered in the evaluation of seronegative rheumatoid arthritis, especially in cases that do not respond predictably to standard therapies, and cutaneous nodule biopsy can aid in differentiating these three conditions. Full article
(This article belongs to the Special Issue Arthritis: From Diagnosis to Treatment)
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