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JCM
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Psoriasis in Focus: Current Research, Treatments, and Future Directions
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Psoriasis in Focus: Current Research, Treatments, and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 492

Special Issue Editors

Dr. Tamara Gracia-Cazaña

E-Mail Website
Guest Editor
Department of Dermatology, Miguel Servet University Hospital, 50009 Zaragoza, Spain
Interests: photodynamic therapy; non-melanoma skin cancer; psoriasis; photodermatology
Special Issues, Collections and Topics in MDPI journals
Dr. Josep Riera-Monroig

E-Mail Website
Guest Editor
Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain
Interests: dermatology; psoriasis; monographic consultation; genodermatosis; sexually transmitted infections

Special Issue Information

Dear Colleagues,

Psoriasis is a chronic, immune-mediated, inflammatory skin disease that reduces individuals’ quality of life and can shorten their lifespan. It affects at least 60 million people worldwide and is associated with several important medical conditions, including cardiometabolic disease, psoriatic arthritis, and depression. Psoriasis poses a challenge for healthcare professionals. In recent years, advances in the understanding of its pathogenesis, as well as the development of novel therapeutic strategies, have transformed the clinical management of this condition.

This Special Issue aims to present recent research on psoriasis, including its immunopathogenesis, genetic predisposition, and environmental triggers. We welcome contributions that address a wide range of topics, such as emerging systemic and topical treatments, biologic and small-molecule therapies, precision medicine approaches, and the role of comorbidities in disease progression. Additionally, we encourage the submission of studies that present patient-reported outcomes, digital health interventions, and real-world data to provide a holistic perspective on psoriasis care.

By compiling high-quality original research, reviews, and clinical studies, this Special Issue seeks to enhance our understanding of psoriasis and foster discussions regarding the future of disease management. We invite researchers and clinicians to contribute their valuable insights and help shape the future of psoriasis treatment.

We look forward to receiving your submissions!

Dr. Tamara Gracia-Cazaña
Dr. Josep Riera-Monroig
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • biologic therapies
  • immunopathogenesis
  • precision medicine
  • comorbidities in psoriasis
  • psoriatic arthritis
  • phototherapy
  • topical treatments
  • systemic therapies

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Published Papers (1 paper)

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Research

12 pages, 1262 KiB  
Article
Exploring the Impact of Gender and Age of Onset on Psoriasis Treatment Management
by Tair Lax, Edia Stemmer, Noga Fallach, Guy Shrem, Michal Schreiber-Divon, Snait Ayalon, Eitan Giat, Inbal Mor and Mali Salmon-Divon
J. Clin. Med. 2025, 14(12), 4090; https://doi.org/10.3390/jcm14124090 - 10 Jun 2025
Viewed by 337
Abstract
Background: Psoriasis is a chronic inflammatory skin disease characterized by a bimodal onset distribution, with cases categorized as early-onset or late-onset. While the prevalence of psoriasis is nearly equal between genders, men typically experience more severe forms of the disease, leading to [...] Read more.
Background: Psoriasis is a chronic inflammatory skin disease characterized by a bimodal onset distribution, with cases categorized as early-onset or late-onset. While the prevalence of psoriasis is nearly equal between genders, men typically experience more severe forms of the disease, leading to differences in treatment approaches and clinical outcomes. The aim of this study was to investigate gender-based differences in treatment patterns among psoriasis patients, with a focus on how these differences vary by disease onset (early vs. late). Methods: A retrospective cohort study including individuals diagnosed with psoriasis between 1998 and 2022 through Clalit Health Services (CHS) in Israel. Gender-based differences in treatment patterns by psoriasis onset were analyzed using Chi-square and Fisher exact tests and survival analyses. Results: The disease onset showed a bimodal distribution among 3999 individuals, with women experiencing earlier onset compared to men (median age 37.2 vs. 40.1 years; p < 0.001). In early-onset psoriasis, men were significantly more likely than women to receive systemic (17.9% vs. 6.5%; p < 0.001) and biological therapies (3.8% vs. 1.6%; p = 0.005) and initiated these treatments earlier (p < 0.001). In contrast, no significant gender-based treatment differences were observed in late-onset cases. Regardless of gender, early-onset patients began phototherapy earlier than late-onset patients (p < 0.001). Conclusions: Our results suggest that disease onset timing may influence treatment decisions and highlight the need for a more personalized approach to psoriasis management that considers both gender and age of onset. Full article
(This article belongs to the Special Issue Psoriasis in Focus: Current Research, Treatments, and Future Directions)
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