Ectopic Fat: Clinical Implications in Obesity and Type 2 Diabetes

Dear Colleagues, 

At present, the prevalence of both obesity and type 2 diabetes (T2D) has reached pandemic levels worldwide, coexisting in many cases in the form of Diabesity. Adipose tissue is a recognized endocrine organ that acts not only as fuel storage but also by secreting various hormones and cytokines with effects on glucose, lipid metabolism, and energy homeostasis. T2D and obesity are linked by various pathophysiological mechanisms, such as adipose tissue dysfunction and insulin resistance. Adipose tissue dysfunction is characterized by large adipocytes and secretion of adipokines with a proinflammatory profile, ultimately leading to ectopic fat deposition in organs such as the liver, skeletal muscle, heart, and pancreas. Ectopic fat can interfere with cellular functions and, hence, organ function. The clinical consequences of ectopic fat accumulation depend on the specific organ, increasing the risk of developing metabolic and cardiovascular diseases.

We invite investigators to contribute with either original research or review articles focusing on the molecular mechanisms and clinical implications of ectopic fat in obesity and T2D, as well as potential therapeutic approaches.

Dr. Andreea Ciudin
Dr. Juan M. Pericàs
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.