Special Issue "New Insights on Acne, Rosacea, and Hidradenitis Suppurativa: Etiology and Treatment"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 November 2022 | Viewed by 2119

Special Issue Editor

Prof. Dr. Hei Sung Kim
E-Mail Website
Guest Editor
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
Interests: acne; rosacea; skin microbiome; lasers and light therapy; cosmetics; itch

Special Issue Information

Dear Colleagues,

Acne, rosacea, and hidradenitis suppurativa (formerly called acne inversa) are skin diseases which share similar features such as redness, papules, nodules. All can result in reduced self-esteem, anxiety, and depression.

With the recent advent of molecular biology and next-generation sequencing (NGS), knowledge on the skin microbiota in these skin conditions has grown exponentially. Additionally, the potential involvement of insulin-like growth factor (IGF)-1 has been suggested in acne, rosacea and hidradenitis suppurativa which opens the possibility for new treatment. Biologics and JAK-inhibitors are also a promising option and should be further examined.

We herein welcome papers which provide exciting new insights on acne, rosacea, and hidradenitis suppurativa.

Prof. Dr. Hei Kim
Guest Editor

Manuscript Submission Information

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Keywords

  • acne
  • rosacea
  • hidradenitis suppurativa
  • new insights
  • etiology
  • treatment
  • skin microbiome
  • IGF-1

Published Papers (3 papers)

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Review

Review
Truncal Acne: An Overview
J. Clin. Med. 2022, 11(13), 3660; https://doi.org/10.3390/jcm11133660 - 24 Jun 2022
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Abstract
Acne is a relatively common disease of the pilosebaceous units. Many aspects of facial acne have been studied. However, there is limited evidence regarding truncal acne. Truncal acne is also observed in a significant number of patients, but it is often ignored by [...] Read more.
Acne is a relatively common disease of the pilosebaceous units. Many aspects of facial acne have been studied. However, there is limited evidence regarding truncal acne. Truncal acne is also observed in a significant number of patients, but it is often ignored by patients and clinicians. Although the pathogenesis of facial and trunk acne is considered to be similar, the characteristics of the skin on the trunk and face are thought to be different. As truncal acne can cause scars on large areas of the body and adversely affect the quality of life of patients, more attention should be given to patients with truncal acne. Although only a few studies have been published to date, the epidemiology, etiology, severity assessment tool, assessments of the quality of life, and new treatments targeting truncal acne are currently being studied. Therefore, in this review, the latest knowledge on truncal acne will be discussed. Full article
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Review
Methods for the Improvement of Acne Scars Used in Dermatology and Cosmetology: A Review
J. Clin. Med. 2022, 11(10), 2744; https://doi.org/10.3390/jcm11102744 - 12 May 2022
Viewed by 464
Abstract
Acne vulgaris is a chronic skin disease that, depending on its course, is characterized by the occurrence of various skin eruptions such as open and closed comedones, pustules, papules, and cysts. Incorrectly selected treatment or the presence of severe acne vulgaris can lead [...] Read more.
Acne vulgaris is a chronic skin disease that, depending on its course, is characterized by the occurrence of various skin eruptions such as open and closed comedones, pustules, papules, and cysts. Incorrectly selected treatment or the presence of severe acne vulgaris can lead to the formation of atrophic scars. In this review, we summarize current knowledge on acne scars and methods for their improvement. There are three types of atrophic scars: icepick, rolling, and boxcar. They are of different depths and widths and have different cross-sections. Scars can combine to form clusters. If acne scars are located on the face, they can reduce the patient’s quality of life, leading to isolation and depression. There are multiple effective modalities to treat acne scars. Ablative lasers, radiofrequency, micro-needling, and pilings with trichloroacetic acid have very good treatment results. Contemporary dermatology and cosmetology use treatments that cause minimal side effects, so the patient can return to daily functioning shortly after treatment. Proper dermatological treatment and skincare, as well as the rapid implementation of cosmetological treatments, will certainly achieve satisfactory results in reducing atrophic scars. Full article
Review
The Role of Skin Immune System in Acne
J. Clin. Med. 2022, 11(6), 1579; https://doi.org/10.3390/jcm11061579 - 13 Mar 2022
Viewed by 900
Abstract
Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which [...] Read more.
Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat. Full article
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