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Minimally Invasive Surgery for Gastrointestinal Disorder

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 631

Special Issue Editor


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Guest Editor
1. Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, USA
2. Division of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
Interests: inflammatory bowel disease; ulcerative colitis; Crohn’s colitis; indeterminate colitis; endoscopic medicine; molecular diagnostics; biomarker; colonic ileal metaplasia; precision diagnostics
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Special Issue Information

Dear Colleagues,

Gastrointestinal diseases are common diseases in the global population, including general inflammatory gastrointestinal diseases, peptic ulcer, gastric cancer, esophageal cancer, colorectal cancer and irritable bowel syndrome. Surgical treatment of gastrointestinal diseases mainly includes open surgery and minimally invasive surgery.

Minimally invasive surgery (MIS) has revolutionized the treatment of gastrointestinal (GI) disorders,  offering significant advantages over traditional open procedures. Leveraging technologies such as laparoscopy and  robotic systems, MIS has become the standard approach for many GI diseases, characterized by smaller incisions,  reduced tissue trauma, faster recovery, and lower rates of complications.

This Special Issue welcomes submissions of research related to gastrointestinal diseases.

Dr. Amosy Ephreim M'Koma
Guest Editor

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Keywords

  • minimally invasive surgery
  • gastrointestinal disorder
  • laparoscopy
  • robotic surgery
  • colorectal surgery
  • gastric surgery
  • endoscopic technique
  • oncological outcomes
  • surgical innovation

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Published Papers (1 paper)

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Research

16 pages, 1968 KB  
Communication
Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis
by Amosy E. M’Koma
J. Clin. Med. 2025, 14(23), 8390; https://doi.org/10.3390/jcm14238390 - 26 Nov 2025
Viewed by 416
Abstract
Background/Objectives: Indeterminate colitis (IC) is an erroneous diagnosis for predominantly colonic inflammatory bowel disease (IBD) when there is a non-definitive foundation of the benchmark for ulcerative colitis (UC) and Crohn’s colitis (CC) after a combined state-of-the-art classification system of clinical, endoscopic, radiologic, and [...] Read more.
Background/Objectives: Indeterminate colitis (IC) is an erroneous diagnosis for predominantly colonic inflammatory bowel disease (IBD) when there is a non-definitive foundation of the benchmark for ulcerative colitis (UC) and Crohn’s colitis (CC) after a combined state-of-the-art classification system of clinical, endoscopic, radiologic, and histologic tools are used. This confounds an effective surgical regimen; specifically pouch surgery, “the restorative proctocolectomy with ileal pouch–anal anastomosis (PRC-IPAA)”. Transforming the distinction between UC and CC in otherwise IC into authentic UC and CC requires priority attention when considering a patient’s candidacy for RPC-IPAA. RPC-IPAA is the accepted standard curative surgical procedure in the treatment for UC (and Familial Adenomatous Polyposis (FAP)). Further, inapproximate/incorrect diagnosis and treatment can sustain potential long-term morbidity from inaccurate and unnecessary surgery and cost. Methods: In trying to resolve these diagnostic ambiguities, the current study advances our understanding by showing the expression of human alpha defensin 5 (DEFA5 alias HD5) restricted in the colon crypt mucosal lining areas, and by identifying the cells of the small intestine (ileum) “colonic ileal metaplasia” in CC that may serve as a biomarker to portray/ascertain authentic CC and UC among IC cohorts, with a positive predictive value (PPV) of 96 percent. Results: Hence, the imprecise diagnosis of IC largely would be circumvented. This new diagnostic tool offers instant tangible benefits over existing diagnostic pathways. The journey toward its widespread clinical use is now subject to logistical and regulatory defiance, which all emerging molecular diagnostic technologies inevitably encounter. Conclusions: The aim of this communication is to provide a summary of the currently available diagnostic advances relating to surgical management for IC in clinical settings, and the related challenges. Further, I briefly discuss aspects of its pathophysiology, surveillance, and diagnostic assay development. Full article
(This article belongs to the Special Issue Minimally Invasive Surgery for Gastrointestinal Disorder)
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